The Three-Dimensional Configuration of the Elastic Fiber Network in Canine Saphenous Vein

1984 ◽  
Vol 21 (4) ◽  
pp. 156-170 ◽  
Author(s):  
Robert S. Crissman
Keyword(s):  
Saphenous Vein ◽  
Elastic Fiber ◽  
Three Dimensional ◽  
Fiber Network ◽  
Canine Saphenous Vein ◽  
Three Dimensional Configuration

Stress-strain curve of paper revisited

2012 ◽  
Vol 27 (2) ◽  
pp. 318-328 ◽  
Author(s):  
Svetlana Borodulina ◽  
Artem Kulachenko ◽  
Mikael Nygårds ◽  
Sylvain Galland
Keyword(s):  
Three Dimensional ◽  
Strain Curve ◽  
Failure Behavior ◽  
Three Dimensional Model ◽  
Stress Strain Curve ◽  
Stress Strain ◽  
Fiber Network ◽  
Bonding Parameters ◽  
Particle Level ◽  
The Impact

Abstract We have investigated a relation between micromechanical processes and the stress-strain curve of a dry fiber network during tensile loading. By using a detailed particle-level simulation tool we investigate, among other things, the impact of “non-traditional” bonding parameters, such as compliance of bonding regions, work of separation and the actual number of effective bonds. This is probably the first three-dimensional model which is capable of simulating the fracture process of paper accounting for nonlinearities at the fiber level and bond failures. The failure behavior of the network considered in the study could be changed significantly by relatively small changes in bond strength, as compared to the scatter in bonding data found in the literature. We have identified that compliance of the bonding regions has a significant impact on network strength. By comparing networks with weak and strong bonds, we concluded that large local strains are the precursors of bond failures and not the other way around.

scholarly journals Improvement on Permeability of Cyclic Peptide/Peptidomimetic: Backbone N-Methylation as A Useful Tool

Marine Drugs ◽  
2021 ◽  
Vol 19 (6) ◽  
pp. 311
Author(s):  
Yang Li ◽  
Wang Li ◽  
Zhengshuang Xu
Keyword(s):  
Cyclic Peptides ◽  
Cyclic Peptide ◽  
Three Dimensional ◽  
Conformational Space ◽  
Cell Permeability ◽  
Relative Importance ◽  
Intrinsic Properties ◽  
Surface Areas ◽  
Synthetic Methodologies ◽  
Three Dimensional Configuration

Peptides have a three-dimensional configuration that can adopt particular conformations for binding to proteins, which are well suited to interact with larger contact surface areas on target proteins. However, low cell permeability is a major challenge in the development of peptide-related drugs. In recent years, backbone N-methylation has been a useful tool for manipulating the permeability of cyclic peptides/peptidomimetics. Backbone N-methylation permits the adjustment of molecule’s conformational space. Several pathways are involved in the drug absorption pathway; the relative importance of each N-methylation to total permeation is likely to differ with intrinsic properties of cyclic peptide/peptidomimetic. Recent studies on the permeability of cyclic peptides/peptidomimetics using the backbone N-methylation strategy and synthetic methodologies will be presented in this review.

Pit pattern and three-dimensional configuration of isolated crypts from the patients with colorectal neoplasm

2002 ◽  
Vol 37 (10) ◽  
pp. 798-806 ◽  
Author(s):  
Satoru Tamura ◽  
Yasuo Furuya ◽  
Takehisa Tadokoro ◽  
Yoshifumi Higashidani ◽  
Yuichi Yokoyama ◽  
...  
Keyword(s):  
Colorectal Neoplasm ◽  
Three Dimensional ◽  
Pit Pattern ◽  
Three Dimensional Configuration

Three-Dimensional Configuration of Subretinal Fluid in Central Serous Chorioretinopathy

2013 ◽  
Vol 54 (9) ◽  
pp. 5944 ◽  
Author(s):  
Soh-Eun Ahn ◽  
Jaeryung Oh ◽  
Jong-Hyun Oh ◽  
In Kyung Oh ◽  
Seong-Woo Kim ◽  
...  
Keyword(s):  
Central Serous Chorioretinopathy ◽  
Three Dimensional ◽  
Subretinal Fluid ◽  
Three Dimensional Configuration
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