Depression of Contractions of Rabbit Aorta and Guinea Pig Vena cava by Mesudipine and Other Slow Channel Blockers

1983 ◽  
Vol 20 (4) ◽  
pp. 172-183 ◽  
Author(s):  
Nick Sperelakis ◽  
Suzanne Mras
Keyword(s):  
Guinea Pig ◽  
Vena Cava ◽  
Rabbit Aorta ◽  
Channel Blockers ◽  
Slow Channel ◽  
Slow Channel Blockers

Adrenergic-cholinergic interactions on membrane potential of K+ -depolarized ventricular muscle

1984 ◽  
Vol 247 (2) ◽  
pp. H244-H250
Author(s):  
T. Ehara ◽  
T. Mitsuiye
Keyword(s):  
Membrane Potential ◽  
Guinea Pig ◽  
Induced Response ◽  
Channel Blockers ◽  
Ventricular Muscle ◽  
Tyrode Solution ◽  
Channel System ◽  
Beta Adrenoceptor ◽  
Slow Channel ◽  
Rebound Increase

In guinea pig ventricular muscles exposed to K+-rich (27 mM) Tyrode solution containing 0.2 mM Ba, catecholamine elicited a slight depolarization of the resting membrane. Application of acetylcholine (ACh) during this catecholamine-induced response caused a repolarization, and removal of ACh induced a transient enhancement in the depolarization (rebound). These effects of ACh were abolished by atropine. Application of ACh alone and its removal had little effect on the membrane potential. Like the catecholamine-induced depolarization, the rebound depolarization after ACh removal was inhibited by slow channel blockers. Thus the rebound was attributed at least in part to enhanced changes in the catecholamine-sensitive conductance, i.e., a beta-receptor-mediated increase in the slow channel conductance. In driven muscles perfused with normal Tyrode solution, there was a rebound increase in twitch tension when ACh was removed in the presence of catecholamine, and this rebound was accompanied by an "extra" elevation of the action potential plateau. Thus cessation of the stimulation of myocardial muscarinic receptors may transiently lead to an enhanced activity of the beta-adrenoceptor-slow channel system in guinea pig ventricular muscle.

Slow Channel Blockers

1983 ◽  
Vol 76 (1) ◽  
pp. 55-64 ◽  
Author(s):  
JOEL O. COVINSKY ◽  
STEPHEN C. HAMBURGER
Keyword(s):  
Channel Blockers ◽  
Slow Channel ◽  
Slow Channel Blockers
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