Alteration of Lung Structure and Function by Pseudomonas aeruginosa

1987 ◽  
Vol 6 (2) ◽  
pp. 93-102 ◽  
Author(s):  
John U. Que ◽  
Donald E. Woods
Keyword(s):  
Structure And Function ◽  
Lung Structure ◽  
And Function

scholarly journals Lung ultrasound presentation of COVID-19 patients: phenotypes and correlations

2021 ◽  
Author(s):  
Gianmarco Secco ◽  
◽  
Marzia Delorenzo ◽  
Francesco Salinaro ◽  
Caterina Zattera ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Lung Ultrasound ◽  
Structure And Function ◽  
General Ward ◽  
Prognostic Role ◽  
Interstitial Syndrome ◽  
Lung Structure ◽  
And Function ◽  
The Relationship

AbstractBedside lung ultrasound (LUS) can play a role in the setting of the SarsCoV2 pneumonia pandemic. To evaluate the clinical and LUS features of COVID-19 in the ED and their potential prognostic role, a cohort of laboratory-confirmed COVID-19 patients underwent LUS upon admission in the ED. LUS score was derived from 12 fields. A prevalent LUS pattern was assigned depending on the presence of interstitial syndrome only (Interstitial Pattern), or evidence of subpleural consolidations in at least two fields (Consolidation Pattern). The endpoint was 30-day mortality. The relationship between hemogasanalysis parameters and LUS score was also evaluated. Out of 312 patients, only 36 (11.5%) did not present lung involvment, as defined by LUS score < 1. The majority of patients were admitted either in a general ward (53.8%) or in intensive care unit (9.6%), whereas 106 patients (33.9%) were discharged from the ED. In-hospital mortality was 25.3%, and 30-day survival was 67.6%. A LUS score > 13 had a 77.2% sensitivity and a 71.5% specificity (AUC 0.814; p < 0.001) in predicting mortality. LUS alterations were more frequent (64%) in the posterior lower fields. LUS score was related with P/F (R2 0.68; p < 0.0001) and P/F at FiO2 = 21% (R2 0.59; p < 0.0001). The correlation between LUS score and P/F was not influenced by the prevalent ultrasound pattern. LUS represents an effective tool in both defining diagnosis and stratifying prognosis of COVID-19 pneumonia. The correlation between LUS and hemogasanalysis parameters underscores its role in evaluating lung structure and function.

Lung Structure And Function Relation In Elastase-Treated Rats: A Long-Term Follow Up Study

2012 ◽  
Author(s):  
Margit V. Szabari ◽  
Jozsef Tolnai ◽  
Balazs Maar ◽  
Harikrishnan Parameswaran ◽  
Elizabeth Bartolak-Suki ◽  
...  
Keyword(s):  
Structure And Function ◽  
Follow Up Study ◽  
Lung Structure ◽  
Long Term Follow Up ◽  
And Function ◽  
Function Relation

scholarly journals Hyperinsulinemia adversely affects lung structure and function

2016 ◽  
Vol 310 (9) ◽  
pp. L837-L845 ◽  
Author(s):  
Suchita Singh ◽  
Manish Bodas ◽  
Naveen K. Bhatraju ◽  
Bijay Pattnaik ◽  
Atish Gheware ◽  
...  
Keyword(s):  
Insulin Treatment ◽  
Epithelial Mesenchymal Transition ◽  
Respiratory Health ◽  
Structure And Function ◽  
Intranasal Insulin ◽  
Mesenchymal Transition ◽  
Inhaled Insulin ◽  
Lung Structure ◽  
Prevalence Of Obesity ◽  
And Function

There is limited knowledge regarding the consequences of hyperinsulinemia on the lung. Given the increasing prevalence of obesity, insulin resistance, and epidemiological associations with asthma, this is a critical lacuna, more so with inhaled insulin on the horizon. Here, we demonstrate that insulin can adversely affect respiratory health. Insulin treatment (1 μg/ml) significantly ( P < 0.05) increased the proliferation of primary human airway smooth muscle (ASM) cells and induced collagen release. Additionally, ASM cells showed a significant increase in calcium response and mitochondrial respiration upon insulin exposure. Mice administered intranasal insulin showed increased collagen deposition in the lungs as well as a significant increase in airway hyperresponsiveness. PI3K/Akt mediated activation of β-catenin, a positive regulator of epithelial-mesenchymal transition and fibrosis, was observed in the lungs of insulin-treated mice and lung cells. Our data suggests that hyperinsulinemia may have adverse effects on airway structure and function. Insulin-induced activation of β-catenin in lung tissue and the contractile effects on ASM cells may be causally related to the development of asthma-like phenotype.

Perinatal Inflammation Negatively Impacts Lung Structure And Function In Adult Mice

2012 ◽  
Author(s):  
Markus Velten ◽  
Rodney D. Britt ◽  
Kathryn M. Heyob ◽  
Trent E. Tipple ◽  
Lynette K. Rogers
Keyword(s):  
Structure And Function ◽  
Adult Mice ◽  
Lung Structure ◽  
And Function

CT-Derived Pulmonary Vascular Volume And Lung Structure And Function In Humans

2012 ◽  
Author(s):  
Sarah Lau ◽  
Courtney M. Wheatley ◽  
Eric C. Wong ◽  
Nicholas A. Cassuto ◽  
Cori L. Daines ◽  
...  
Keyword(s):  
Structure And Function ◽  
Vascular Volume ◽  
Lung Structure ◽  
And Function

scholarly journals Tenascin-C inactivation impacts lung structure and function beyond lung development

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Sandrine Gremlich ◽  
Matthias Roth-Kleiner ◽  
Lucile Equey ◽  
Kleanthis Fytianos ◽  
Johannes C. Schittny ◽  
...  
Keyword(s):  
Lung Development ◽  
Structure And Function ◽  
Tenascin C ◽  
Lung Structure ◽  
And Function

scholarly journals Author response to letter to editor: Hyperinsulinemia adversely affects lung structure and function

2016 ◽  
Vol 311 (1) ◽  
pp. L183-L184 ◽  
Author(s):  
Suchita Singh ◽  
Manish Bodas ◽  
Naveen K. Bhatraju ◽  
Bijay Pattnaik ◽  
Atish Gheware ◽  
...  
Keyword(s):  
Structure And Function ◽  
Author Response ◽  
Lung Structure ◽  
And Function
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