Adhesive Strength of Fibrinogen-Coated Collagen Patch or Liquid Fibrin Sealant in an Experimental Liver Resection Model in Pigs

2008 ◽  
Vol 41 (3) ◽  
pp. 298-302 ◽  
Author(s):  
D. Erdogan ◽  
W. de Graaf ◽  
T.M. van Gulik
Keyword(s):  
Liver Resection ◽  
Adhesive Strength ◽  
Fibrin Sealant ◽  
Experimental Liver ◽  
Coated Collagen

scholarly journals Postoperative bleeding and biliary leak after liver resection: A cohort study between two different fibrin sealant patches

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Diego López-Guerra ◽  
Jesús Santos-Naharro ◽  
Adela Rojas-Holguín ◽  
Isabel Jaen-Torrejimeno ◽  
Aranzazu Prada-Villaverde ◽  
...  
Keyword(s):  
Cohort Study ◽  
Liver Resection ◽  
Fibrin Sealant ◽  
Postoperative Bleeding ◽  
Biliary Leak

Effect of major liver resection on colon cancer metastasis in the lung and liver.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e14014-e14014
Author(s):  
Robert M. Hoffman ◽  
Masashi Momiyama ◽  
Atsushi Suetsugu ◽  
Hiroyuki Kishimoto ◽  
Takashi Chishima ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Liver Resection ◽  
Fluorescent Protein ◽  
Metastatic Tumor ◽  
Liver Parenchyma ◽  
Major Liver Resection ◽  
Colon 26 ◽  
Metastatic Growth ◽  
Major Resection ◽  
Experimental Liver

e14014 Background: Liver resection is a common procedure in liver-metastatic colon cancer. However, recurrence is common and distant liver metastasis may be appear after liver resection. Methods: Experimental liver metastases were established by spleen injection of the Colon 26 murine colon cancer cell line expressing green fluorescent protein (GFP) into transgenic nude mice expressing red fluorescent protein (RFP). Experimental liver metastases was established by splenic injection of Colon-26-GFP. Experimental lung metastases were established by tail vein injection with Colon 26-GFP. Three days after cell injection into the spleen or tail vein, groups of mice underwent liver resection (35%+35% [repeated minor resection] vs. 70% [major resection]). Metastatic tumor growth was measured by color-coded fluorescence imaging of the GFP-expressing cancer cells and RFP-expressing stroma. Results: Although major and repeated minor resection removed the same volume of liver parenchyma, the two procedures had very different effects on metastatic tumor growth. Major resection, stimulated liver and lung metastatic growth as well as recruitment of host-derived stroma into the metastases compared to repeated minor resection. Repeated minor resection did not stimulate metastasis or stromal recruitment. There was no significant difference in liver regeneration between the two groups. TGF-β was also preferentially stimulated by major resection. Conclusions: Host-derived stroma density, which is stimulated by major resection compared to repeated minor resection, may stimulate metastatic growth. Stromal growth may be stimulated by TGF-β. The results of this study indicate that caution should be taken when planning a major liver resection for metastatic colorectal cancer. Conservative resections that spare liver parenchyma should be considered whenever possible.

Fibrin Sealant for Prevention of Resection Surface-Related Complications After Liver Resection

2012 ◽  
Vol 256 (2) ◽  
pp. 229-234 ◽  
Author(s):  
Marieke T. de Boer ◽  
Joost M. Klaase ◽  
Cornelis Verhoef ◽  
Ronald M. van Dam ◽  
Thomas M. van Gulik ◽  
...  
Keyword(s):  
Liver Resection ◽  
Fibrin Sealant

scholarly journals Effects of primary suture and fibrin sealant on hemostasis and liver regeneration in an experimental liver injury

2008 ◽  
Vol 14 (1) ◽  
pp. 81 ◽  
Author(s):  
Arif Hakan Demirel ◽  
Ozgur Taylan Basar ◽  
Ali Ulvi Ongoren ◽  
Erkut Bayram ◽  
Mustafa Kisakurek
Keyword(s):  
Liver Injury ◽  
Liver Regeneration ◽  
Fibrin Sealant ◽  
Primary Suture ◽  
Experimental Liver

Effectiveness of a new carrier-bound fibrin sealant versus argon beamer as haemostatic agent during liver resection: a randomised prospective trial

2005 ◽  
Vol 390 (2) ◽  
pp. 114-120 ◽  
Author(s):  
Andrea Frilling ◽  
Gregor A. Stavrou ◽  
Hans-Jörg Mischinger ◽  
Bernard de Hemptinne ◽  
Mogens Rokkjaer ◽  
...  
Keyword(s):  
Liver Resection ◽  
Fibrin Sealant ◽  
Prospective Trial ◽  
Haemostatic Agent
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