Integrated Analysis of Copy Number Alterations and Loss of Heterozygosity in Human Pancreatic Cancer Using a High-Resolution, Single Nucleotide Polymorphism Array

Oncology ◽  
2008 ◽  
Vol 75 (1-2) ◽  
pp. 102-112 ◽  
Author(s):  
Lian-Jie Lin ◽  
Yoshinari Asaoka ◽  
Motohisa Tada ◽  
Masashi Sanada ◽  
Yasuhito Nannya ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Single Nucleotide Polymorphism ◽  
Copy Number ◽  
Single Nucleotide Polymorphism Array ◽  
Human Pancreatic Cancer ◽  
Integrated Analysis ◽  
Copy Number Alterations ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Resolution Single

scholarly journals Analysis of somatic copy number alterations in biliary tract carcinoma using a single nucleotide polymorphism array

2021 ◽  
Author(s):  
Yoshihiro Shioi ◽  
Mitsumasa Osakabe ◽  
Naoki Yanagawa ◽  
Hiroyuki Nitta ◽  
Akira Sasaki ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Biliary Tract ◽  
Copy Number ◽  
Single Nucleotide Polymorphism Array ◽  
Biliary Tract Carcinoma ◽  
Copy Number Alterations ◽  
Nucleotide Polymorphism ◽  
Duct Carcinoma ◽  
Single Nucleotide ◽  
Somatic Copy Number Alterations

Aim: Biliary tract carcinoma (BTC), including gall bladder carcinoma (GBC) and biliary duct carcinoma (BDC), has a poor prognosis. Comprehensive genomic profiling has important roles in evaluation of the carcinogenesis of BTC. Materials & methods: We examined somatic copy number alterations (SCNAs) using a single nucleotide polymorphism array system to analyze 36 BTC samples (11 GBCs and 25 BDCs). Results: In hierarchical cluster analysis, two clusters were identified (subgroup 1 with low SCNAs and subgroup 2 with high SCNAs). GBC was predominant in subgroup 1, whereas BDC was predominant in subgroup 2, suggesting that GBC and BDC had different genetic backgrounds in terms of SCNAs. Conclusion: These findings could be helpful for establishing the molecular carcinogenesis of BTCs.

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