Tissue-Specific Alternative RNA Processing in Calcitonin/ Calcitonin Gene-Related Peptide Gene Expression

1993 ◽  
Vol 3 (3-4) ◽  
pp. 181-196 ◽  
Author(s):  
Ronald B. Emeson ◽  
Joanne M. Yeakley
Keyword(s):  
Gene Expression ◽  
Rna Processing ◽  
Calcitonin Gene Related Peptide ◽  
Tissue Specific ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Specific Alternative ◽  
Peptide Gene

scholarly journals Alternative RNA processing--its role in regulating expression of calcitonin/calcitonin gene-related peptide

1998 ◽  
Vol 156 (3) ◽  
pp. 401-405 ◽  
Author(s):  
H Lou ◽  
RF Gagel
Keyword(s):  
Rna Processing ◽  
Calcitonin Gene Related Peptide ◽  
Regulatory Mechanisms ◽  
Terminal Exon ◽  
Tissue Specific ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Specific Regulation ◽  
Intron 4

The calcitonin/calcitonin gene-related peptide (CT/CGRP) gene is one of the earliest studied examples of alternative RNA processing. The regulatory mechanisms controlling this event are poorly understood. We have identified and characterized an intron element residing in intron 4 of the human CT/CGRP gene. This intron element functions to enhance polyadenylation of an embedded alternative 3'-terminal exon within the CT/CGRP gene and is potentially involved in tissue-specific regulation of CT/CGRP RNA processing.

Calcitonin gene related peptide gene expression in collagen-induced arthritis

1995 ◽  
Vol 73 (7) ◽  
pp. 1015-1019 ◽  
Author(s):  
Eberhard Weihe ◽  
Donatus Nohr ◽  
Martin K.-H. Schäfer ◽  
Stefan Persson ◽  
Johanna Källström ◽  
...  
Keyword(s):  
Gene Expression ◽  
Motor Neurons ◽  
Calcitonin Gene Related Peptide ◽  
Motor Dysfunction ◽  
Mrna Levels ◽  
Related Peptide ◽  
Inflammatory Conditions ◽  
Systemic Corticosteroids ◽  
Calcitonin Gene ◽  
Peptide Gene

Changes in calcitonin gene related peptide (CGRP) gene expression in spinal motoneurons and dorsal root ganglia (DRG) of rats subjected to collagen II induced arthritis (CIA) were evaluated by semiquantitative in situ hybridization. The effects of systemic treatment with the corticosteroid budesonide on basal CGRP expression and on changes under inflammatory conditions were examined. CIA caused a significant increase in CGRP mRNA levels in DRG. Budesonide reduced the constitutive CGRP mRNA levels in DRG, compared with untreated control rats, and reversed the CIA-induced increase. In contrast, CIA caused a marked decrease of CGRP mRNA levels in motoneurons. Budesonide had no effect on constitutive CGRP mRNA levels in motoneurons and attenuated the decrease in CGRP mRNA levels in motoneurons of rats subjected to CIA. Thus, peripheral inflammation and systemic corticosteroids have differential effects on CGRP expression in sensory and motor neurons. This may be relevant for the pathophysiology and pharmacotherapy of chronic inflammatory pain and motor dysfunction in chronic arthritis.Key words: calcitonin gene related peptide, neuropeptides, sensory, spinal motoneuron, arthritis, glucocorticoids, pain.

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