Aldosterone Stimulates Cellular K+ Uptake and K+ Release in the Diluting Segment of the Frog Kidney

1991 ◽  
Vol 1 (2) ◽  
pp. 89-97 ◽  
Author(s):  
Hans-Jürgen Westphale ◽  
Christof Schäfer ◽  
Hans Oberleithner
Keyword(s):  
Frog Kidney ◽  
Diluting Segment

Amiloride reduces potassium conductance in frog kidney via inhibition of Na+-H+ exchange

1986 ◽  
Vol 251 (1) ◽  
pp. F66-F73
Author(s):  
H. Oberleithner ◽  
G. Munich ◽  
A. Schwab ◽  
P. Dietl
Keyword(s):  
Cell Membrane ◽  
Potassium Conductance ◽  
Membrane Resistance ◽  
Frog Kidney ◽  
High Potassium ◽  
Diluting Segment ◽  
Nephron Segment ◽  
Net Flux ◽  
Kidney Perfusion ◽  
K Concentration

The existence of a carrier-mediated Na+-H+ exchange has been described recently in many epithelial and nonepithelial tissues including the diluting segment of the amphibian kidney. In this preparation the Na+-H+ exchanger is dramatically stimulated by so-called K+ adaptation (chronic exposure of animals to high potassium) and completely inhibited by the diuretic drug amiloride. We performed electrophysiological experiments in diluting segments of the isolated perfused frog kidney to investigate whether amiloride affects the conductance properties of this epithelium. Amiloride dramatically increased the transepithelial resistance and the ratio of lumen over peritubular cell membrane resistance. Cell membrane potential changes, induced by luminal K+ concentration steps, were blunted by luminal application of amiloride, by luminal Na+-free perfusates, or by acidification of the kidney perfusion solution. K+ secretory net flux, measured by K+-sensitive microelectrodes, decreased by half in presence of the diuretic. The experiments reveal that amiloride reduces the K+ conductance of the luminal cell membrane of frog diluting segment via inhibition of the luminal Na+-H+ exchanger. This decreases transepithelial K+ net secretion in this nephron segment.

Contrasting Action of H+ and Ca2+ on K+ Transport in the Diluting Segment of Frog Kidney

1991 ◽  
Vol 1 (5-6) ◽  
pp. 286-293 ◽  
Author(s):  
Christof Schäfer ◽  
Hans-Jürgen Westphale ◽  
Hans Oberleithner
Keyword(s):  
Frog Kidney ◽  
Diluting Segment

Relationship between luminal Na+/H+ exchange and luminal K+ conductance in diluting segment of frog kidney

1985 ◽  
Vol 405 (S1) ◽  
pp. S110-S114 ◽  
Author(s):  
H. Oberleithner ◽  
P. Dietl ◽  
G. M�nich ◽  
M. Weigt ◽  
A. Schwab
Keyword(s):  
Frog Kidney ◽  
Diluting Segment

Mechanism of hydrogen ion transport in the diluting segment of frog kidney

1984 ◽  
Vol 402 (3) ◽  
pp. 272-280 ◽  
Author(s):  
Hans Oberleithner ◽  
Florian Lang ◽  
Georg Messner ◽  
Wenhui Wang
Keyword(s):  
Ion Transport ◽  
Hydrogen Ion ◽  
Frog Kidney ◽  
Diluting Segment ◽  
Hydrogen Ion Transport

Ca2+ transport in diluting segment of frog kidney

1987 ◽  
Vol 410 (1-2) ◽  
pp. 63-68 ◽  
Author(s):  
Paul Dietl ◽  
Hans Oberleithner
Keyword(s):  
Frog Kidney ◽  
Diluting Segment
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