Application of DNA Profiling to Paternity Testing during Early Pregnancy

1993 ◽  
Vol 43 (6) ◽  
pp. 357-361 ◽  
Author(s):  
Liu Mingjun ◽  
Xin Zhenghan ◽  
Ivan Balazsc
Keyword(s):  
Early Pregnancy ◽  
Dna Profiling ◽  
Paternity Testing

DNA-Profiling with pHINS310, pMUC7, pMR24/1, pYNH24 and pMS43a for Paternity Testing

1992 ◽  
pp. 204-206
Author(s):  
T. Rothämel ◽  
H.-J. Krüger ◽  
W. Keil ◽  
H. D. Tröger
Keyword(s):  
Dna Profiling ◽  
Paternity Testing

scholarly journals A Unique Allele Variant at STR Locus D2S1338 in a Paternity Testing Case

2021 ◽  
Vol 3 (1) ◽  
pp. 109-117
Author(s):  
Sajjad Ahmad ◽  
Sadaqat ALi ◽  
Nasir Siddique ◽  
Qazi Laeeque Ahmad ◽  
Muhammad Amjad ◽  
...  
Keyword(s):  
Allelic Variation ◽  
Rare Allele ◽  
Dna Profiling ◽  
Paternity Testing ◽  
Null Alleles ◽  
Allelic Ladder ◽  
Unique Allele ◽  
Dna Database ◽  
Allele Variant ◽  
Testing Case

Background: The relationship testing through DNA profiling may undesirably be affected by the rare allele variants, tri-allelic pattern and null alleles. Therefore, it is vital to report such anomalies. We report a paternity testing in a sexual assault case studied at Punjab Forensic Science Agency, Lahore Pakistan showing a unique allele variant in mother and child. Methods: DNA was extracted from the buccal swabs of reference samples using organic extraction method and DNA profiling was done for 15 autosomal STRs and amelogenin using Identifiler Plus kit. Results: A novel out of marker range (OMR) allele variant between STR Loci D16S539 and D2S1338 was observed in the DNA profiles of victim (mother) as well as the child. At STR locus D2S1338 Twenty one different allele variant are listed at STRBase ranging from 11 to 28. The allele variant observed in this case study was appeared at less than marker range (< D2S1338) with a size of 297.50 bp. The novel variant OMR allele at D2S1338 was labeled as allele 13, when compared to the other allele in allelic ladder. Moreover, the PFSA DNA database was searched for this unique allelic variation and it was found that this was present in only two other samples of distinct cases. Conclusion: The overall frequency of this unique allele variant was 3 in 10,125 unrelated individuals with frequency of occurrence of 0.0296. According to our limited knowledge it is the first report of a novel OMR allele variant at D2S1338 in Pakistani Population.

Sexual Abuse and Early Pregnancy in Young Women's Lives

1995 ◽  
Vol 40 (9) ◽  
pp. 889-890
Author(s):  
Valerie J. Steffen
Keyword(s):  
Sexual Abuse ◽  
Early Pregnancy ◽  
Women's Lives

Maternal free cortisol in early pregnancy and its association to fetal stress response

2005 ◽  
Vol 113 (08) ◽  
Author(s):  
MI Rieger ◽  
A Buske-Kirschbaum ◽  
H Wurmser ◽  
M Papoušek ◽  
KM Pirke ◽  
...  
Keyword(s):  
Stress Response ◽  
Early Pregnancy ◽  
Free Cortisol

Association of serum hCG level with miscarriage in early pregnancy

2019 ◽  
Vol 3 (3) ◽  
pp. 141-144
Author(s):  
Meena Dr. Priyanka ◽  
Mathur Dr. Rati ◽  
Meena Dr. Mohan Lal ◽  
Simlot Dr. Anita
Keyword(s):  
Early Pregnancy

ZUR BEDEUTUNG DES HYPOPHYSÄREN LUTEINISIERUNGSHORMONS FÜR SCHWANGERSCHAFT, GEBURT UND LACTATION BEI DER RATTE

1970 ◽  
Vol 65 (3_Suppl) ◽  
pp. S5-S32 ◽  
Author(s):  
K. Loewit
Keyword(s):  
Luteinizing Hormone ◽  
Early Pregnancy ◽  
Hydroxysteroid Dehydrogenase ◽  
The State ◽  
Termination Of Pregnancy ◽  
Progesterone Level ◽  
Corpora Lutea ◽  
Regulatory Properties ◽  
Duration Of Pregnancy

ABSTRACT The role of luteinizing hormone (LH) for the maintenance of pregnancy, parturition and lactation was investigated by immunological and histochemical methods in the rat. Neutralisation of endogenous rat-LH with Rabbit-Anti-Bovine-LH-Serum (selective hypophysectomy) from days 7-12 of pregnancy resulted in reabsorption of the foetuses and the reappearance of strong 20α-hydroxysteroid-dehydrogenase (20α-OHSD) activity in the corpora lutea (CL) of pregnancy, which normally show no such activity at that time. This effect could be prevented in part by concurrent pregnenolone administration and fully by progesterone, but was not influenced by oestrogen or prolactin. It is concluded that in early pregnancy LH is the main luteotrophic hormone in the rat even though prolactin might act synergistically with it. Antiserum treatment after the 12th day of gestation had no influence on the state or duration of pregnancy or on parturition. LH-injections during the first half of pregnancy had no luteolytic effects i. e. they did not activate 20α-OHSD activity. After day 16 they advanced the reappearance of the enzyme, but delayed parturition or resulted in stillbirths. Neither LH nor antiserum seemed to alter lactation. Since progesterone prevented both the termination of pregnancy and the recurrence of 20α-OHSD activity, it should have some regulatory properties on the enzyme. It is discussed whether the gonadotrophin-dependent progesterone level could regulate the 20α-OHSD activity rather than result from it.

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