Multipoint Mapping under Genetic Interference

1993 ◽  
Vol 43 (2) ◽  
pp. 86-97 ◽  
Author(s):  
Daniel E. Weeks ◽  
Mark Lathrop ◽  
Jurg Ott
Keyword(s):  
Genetic Interference ◽  
Multipoint Mapping

scholarly journals Models for Chromatid Interference With Applications to Recombination Data

Genetics ◽  
2000 ◽  
Vol 156 (3) ◽  
pp. 1449-1460
Author(s):  
F Teuscher ◽  
G A Brockmann ◽  
P E Rudolph ◽  
H H Swalve ◽  
V Guiard
Keyword(s):  
Real Data ◽  
New Model ◽  
The Third ◽  
Genetic Interference ◽  
Three Components

Abstract Genetic interference means that the occurrence of one crossover affects the occurrence and/or location of other crossovers in its neighborhood. Of the three components of genetic interference, two are well modeled: the distribution of the number and the locations of chiasmata. For the third component, chromatid interference, there exists only one model. Its application to real data has not yet been published. A further, new model for chromatid interference is presented here. In contrast to the existing model, it is assumed that chromatid interference acts only in the neighborhood of a chiasma. The appropriateness of this model is demonstrated by its application to three sets of recombination data. Both models for chromatid interference increased fit significantly compared to assuming no chromatid interference, at least for parts of the chromosomes. Interference does not necessarily act homogeneously. After extending both models to allow for heterogeneity of chromatid interference, a further improvement in fit was achieved.

scholarly journals Stem cells and fluid flow drive cyst formation in an invertebrate excretory organ

eLife ◽  
2015 ◽  
Vol 4 ◽  
Author(s):  
Hanh Thi-Kim Vu ◽  
Jochen C Rink ◽  
Sean A McKinney ◽  
Melainia McClain ◽  
Naharajan Lakshmanaperumal ◽  
...  
Keyword(s):  
Molecular Mechanisms ◽  
Kidney Diseases ◽  
Human Kidney ◽  
Cyst Formation ◽  
Cystic Kidney ◽  
Flow Sensing ◽  
Cell Proliferation And Differentiation ◽  
Proliferation And Differentiation ◽  
Genetic Interference ◽  
Cystic Kidney Diseases

Cystic kidney diseases (CKDs) affect millions of people worldwide. The defining pathological features are fluid-filled cysts developing from nephric tubules due to defective flow sensing, cell proliferation and differentiation. The underlying molecular mechanisms, however, remain poorly understood, and the derived excretory systems of established invertebrate models (Caenorhabditis elegans and Drosophila melanogaster) are unsuitable to model CKDs. Systematic structure/function comparisons revealed that the combination of ultrafiltration and flow-associated filtrate modification that is central to CKD etiology is remarkably conserved between the planarian excretory system and the vertebrate nephron. Consistently, both RNA-mediated genetic interference (RNAi) of planarian orthologues of human CKD genes and inhibition of tubule flow led to tubular cystogenesis that share many features with vertebrate CKDs, suggesting deep mechanistic conservation. Our results demonstrate a common evolutionary origin of animal excretory systems and establish planarians as a novel and experimentally accessible invertebrate model for the study of human kidney pathologies.

Linkage group I: multipoint mapping

1975 ◽  
Vol 14 (3-6) ◽  
pp. 381-389 ◽  
Author(s):  
D.A. Meyers ◽  
P.M. Conneally ◽  
F. Hecht ◽  
E.W. Lovrien ◽  
E. Magenis ◽  
...  
Keyword(s):  
Linkage Group ◽  
Group I ◽  
Multipoint Mapping

Efficient multipoint mapping: making use of dominant repulsion-phase markers

2003 ◽  
Vol 107 (6) ◽  
pp. 1102-1112 ◽  
Author(s):  
D. I. Mester ◽  
Y. I. Ronin ◽  
Y. Hu ◽  
J. Peng ◽  
E. Nevo ◽  
...  
Keyword(s):  
Repulsion Phase ◽  
Multipoint Mapping

scholarly journals A comment on Xie and Xu: ‘Mapping quantitative trait loci in tetraploid species’

2001 ◽  
Vol 78 (2) ◽  
pp. 187-189 ◽  
Author(s):  
CHRISTINE A. HACKETT
Keyword(s):  
Quantitative Trait Loci ◽  
Quantitative Trait ◽  
Biological Process ◽  
Tetraploid Species ◽  
Gamete Formation ◽  
Trait Loci ◽  
Realistic Formulation ◽  
Multipoint Mapping

Xie & Xu (2000) present a model for mapping quantitative trait loci in an autotetraploid population. However, one aspect of their model, namely gamete formation, does not properly represent the biological process in autotetraploid species. This paper gives a more realistic formulation for this part of the model, and discusses the consequences for multipoint mapping.

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