scholarly journals MBD2-Mediated Transcriptional Repression of the p14ARF Tumor Suppressor Gene in Human Colon Cancer Cells

Pathobiology ◽  
2008 ◽  
Vol 75 (5) ◽  
pp. 281-287 ◽  
Author(s):  
Valérie Martin ◽  
Helle F. Jørgensen ◽  
Audrey S. Baur Chaubert ◽  
Jennifer Berger ◽  
Helen Barr ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Tumor Suppressor Gene ◽  
Transcriptional Repression ◽  
Human Colon ◽  
Suppressor Gene ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Human Colon Cancer Cells

scholarly journals Cystatin D is a candidate tumor suppressor gene induced by vitamin D in human colon cancer cells

2009 ◽  
Vol 119 (8) ◽  
pp. 2343-2358 ◽  
Author(s):  
Silvia ρlvarez-Díaz ◽  
Noelia Valle ◽  
José Miguel García ◽  
Cristina Peña ◽  
José M.P. Freije ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Vitamin D ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Human Colon ◽  
Suppressor Gene ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Candidate Tumor Suppressor Gene ◽  
Human Colon Cancer Cells

scholarly journals The αE-catenin gene (CTNNA1) acts as an invasion-suppressor gene in human colon cancer cells

Oncogene ◽  
1999 ◽  
Vol 18 (4) ◽  
pp. 905-915 ◽  
Author(s):  
Stefan J Vermeulen ◽  
Friedel Nollet ◽  
Erik Teugels ◽  
Krist'l M Vennekens ◽  
Fransiska Malfait ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Human Colon ◽  
Suppressor Gene ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Human Colon Cancer Cells

scholarly journals ESE-1/ELF3 Is a Tumor Suppressor and Molecular Target of Green Tea Compound, EGCG (P05-009-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Taekyu Ha ◽  
Jihye Lee ◽  
Zhiyuan Lou ◽  
Bok-Soon Lee ◽  
Chul-Ho Kim ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Nuclear Localization ◽  
Human Colon ◽  
Molecular Target ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Anti Cancer ◽  
Human Colon Cancer Cells

Abstract Objectives Epithelial Specific ETS-1 (ESE-1), also known as E74-Like Factor 3 (ELF3), belongs to the E26 transformation-specific transcription factor superfamily and is of great interest as a potential target for managing several types of cancer. The objectives of this study are to investigate whether ESE-1/ELF3 is a tumor suppressor and to identify dietary anti-cancer compound to activate ESE-1/ELF3 expression in human colon cancer model. Methods The formation of aberrant crypt foci (ACF) was examined in wild type and ESE-1/ELF3 knockout mice exposed to combination of azoxymethane (AOM) and dextran sulfate sodium (DSS). Stable human colon cancer cell lines expressing ESE-1/ELF3 were established and used for xenograft study and in vitro mechanistic studies. Many bioactive phytochemicals were screened based on the activation of ESE-1/ELF3 expression. Results ESE-1/ELF3 knockout in mice increased AOM-induced and DSS-promoted formation of ACF. Conversely, overexpression of ESE-1/ELF3 suppressed tumorigenicity in a xenograft mouse study and repressed anchorage-independent growth and migration/invasion in human colon cancer cells. Full length ESE-1/ELF3 localized abundantly in the nucleus, and internal deletion of nuclear localization sequence 2 (NLS2) reduced nuclear ESE-1/ELF3. Three lysine residues (318KKK320) in the NLS2 determine its nuclear localization. We identified epigallocatechin-3-gallate (EGCG) that acts as a transcriptional activator of ESE-1/ELF3 in human colon cancer cells. Conclusions These findings propose a novel and promising molecular target of dietary anti-cancer compounds for prevention of colon cancer. Funding Sources American Cancer Society. Supporting Tables, Images and/or Graphs

Extravirgin olive oil up-regulates CB1 tumor suppressor gene in human colon cancer cells and in rat colon via epigenetic mechanisms

2015 ◽  
Vol 26 (3) ◽  
pp. 250-258 ◽  
Author(s):  
Andrea Di Francesco ◽  
Anastasia Falconi ◽  
Clara Di Germanio ◽  
Maria Vittoria Micioni Di Bonaventura ◽  
Antonio Costa ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Olive Oil ◽  
Cancer Cells ◽  
Human Colon ◽  
Suppressor Gene ◽  
Rat Colon ◽  
Epigenetic Mechanisms ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Human Colon Cancer Cells

scholarly journals Extracellular Disposal of Tumor-Suppressor miRs-145 and -34a via Microvesicles and 5-FU Resistance of Human Colon Cancer Cells

2014 ◽  
Vol 15 (1) ◽  
pp. 1392-1401 ◽  
Author(s):  
Yukihiro Akao ◽  
Fiona Khoo ◽  
Minami Kumazaki ◽  
Haruka Shinohara ◽  
Kohei Miki ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Human Colon ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Human Colon Cancer Cells

Leptin is a growth factor for human colon cancer cells

2001 ◽  
Vol 120 (5) ◽  
pp. A493-A493
Author(s):  
J HARDWICK ◽  
G VANDENBRINK ◽  
S VANDEVENTER ◽  
M PEPPELENBOSCH
Keyword(s):  
Colon Cancer ◽  
Growth Factor ◽  
Cancer Cells ◽  
Human Colon ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Human Colon Cancer Cells
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