Are New-Generation Bisphosphonates Effective for the Inhibition of Calcium Oxalate Stone Formation in a Rat Model?

2008 ◽  
Vol 81 (3) ◽  
pp. 325-329 ◽  
Author(s):  
Erem Kaan Basok ◽  
Adnan Basaran ◽  
Necmettin Atsu ◽  
Asif Yildirim ◽  
Resit Tokuc
Keyword(s):  
Calcium Oxalate ◽  
Rat Model ◽  
Stone Formation ◽  
Calcium Oxalate Stone ◽  
New Generation

Clinical Results of Allopurinol Treatment in Prevention of Calcium Oxalate Stone Formation

1986 ◽  
Vol 136 (1 Part 1) ◽  
pp. 50-53 ◽  
Author(s):  
Hans-Göran Tiselius ◽  
Lasse Larsson ◽  
Erik Hellgren
Keyword(s):  
Calcium Oxalate ◽  
Stone Formation ◽  
Clinical Results ◽  
Calcium Oxalate Stone

The Effect of Ethane-1-Hydroxy-1,1-Diphosphonate (EHDP) on Calcium Oxalate Crystalluria in Recurrent Renal Stone-Formers

1974 ◽  
Vol 47 (1) ◽  
pp. 13-22 ◽  
Author(s):  
W. G. Robertson ◽  
M. Peacock ◽  
R. W. Marshall ◽  
F. Knowles
Keyword(s):  
Calcium Oxalate ◽  
Stone Formation ◽  
Basal Diet ◽  
Sodium Oxalate ◽  
Calcium Oxalate Crystals ◽  
Calcium Oxalate Dihydrate ◽  
Calcium Oxalate Stone ◽  
Oxalate Crystals ◽  
Stone Formers

1. The volume, size and type of calcium oxalate crystals excreted in the urine of a group of patients with recurrent ‘idiopathic’ stones were studied on a controlled basal diet, after an oral supplement of sodium oxalate and after oral administration of ethane-1-hydroxy-1,1-diphosphonate (EHDP) for 4 weeks. 2. Before administration of EHDP the stone-formers passed the large crystals and aggregates of calcium oxalate dihydrate characteristic of recurrent calcium oxalate stone-formers. For the same level of urine saturation and crystalluria EHDP caused a significant reduction in the proportion of large crystals and aggregates excreted. Studies by light-microscopy confirmed that EHDP caused a striking change in the size and habit of calcium oxalate crystals in some but not all of the urine samples examined. 3. The decrease in average crystal size during the administration of EHDP was attributed to the observed increase in the ability of urine to inhibit the growth and aggregation of calcium oxalate crystals as measured by a growth system in vitro. 4. The possible use of EHDP as a therapeutic agent in the treatment of calcium oxalate stone-formation is discussed.

A Comparative Study of Experimental Rat Models of Renal Calcium Oxalate Stone Formation

2011 ◽  
Vol 25 (6) ◽  
pp. 1057-1061 ◽  
Author(s):  
Seung Young Oh ◽  
Jong Kyou Kwon ◽  
Seo Yeon Lee ◽  
Moon Soo Ha ◽  
Yong Wook Kwon ◽  
...  
Keyword(s):  
Comparative Study ◽  
Calcium Oxalate ◽  
Stone Formation ◽  
Calcium Oxalate Stone ◽  
Rat Models

scholarly journals PSIII-36 Increased viscosity enhances water intake and reduces risk of calcium oxalate stone formation in cats

2019 ◽  
Vol 97 (Supplement_3) ◽  
pp. 276-277
Author(s):  
Melissa Vanchina ◽  
Blair Ogleby ◽  
Dennis E Jewell
Keyword(s):  
Calcium Oxalate ◽  
Water Consumption ◽  
Stone Formation ◽  
Significant Risk ◽  
Fractional Excretion ◽  
Urinary Calcium ◽  
Urine Specific Gravity ◽  
Average Weight ◽  
Calcium Oxalate Stone ◽  
Urinary Tract Stone

Abstract The control of liquid intake in cats is especially of interest as there is a significant risk of urinary tract stone formation due to their high urinary solute density. Calcium oxalate stone formation is not easily mitigated by dietary manipulation. This study investigated if increasing water viscosity (282 vs 2.9 centipoise; means throughout are viscous water followed by control cats) improved voluntary intake of water and calcium oxalate stone risk. Twelve cats (7 neutered males, 5 spayed females) from 3 to 8 years of age with an average weight 4.7 kg were monitored for 4 months. Each cat spent 2 months consuming viscous water and two months consuming normal water in a crossover design. Water consumption was measured through loss of weight from each pet’s water bowl with an additional bowl of the consumed viscosity placed in the room for evaporative loss measurements. A urine calcium oxalate titrimetric test (COT) was performed to evaluate the risk of calcium oxalate stone formation. In brief, the [Ca+2]/(added Oxalate-2) ratio is calculated (per liter). An increasing index value denotes samples at greater risk of calcium oxalate crystallization. The ratio represents the concentration of ionized calcium and the amount of oxalate that is added to initiate crystallization. The results showed that cats drinking viscous water had a significant increase in water consumption (79.9 vs 65.6 grams P = 0.014). There was a reduction in urine specific gravity (1.042 vs 1.052 P = 0.016), fractional excretion of calcium (0.197 vs 0.280 P = 0.036), urinary calcium concentration (49.8 vs 61.8 ppm P < 0.01) and in stone risk as measured by COT (35.5 vs 82.4 P = 0.029). In conclusion, these data show that there is an increased intake of water when cats are offered water with increased viscosity and increased viscosity was associated with an improvement in measurements of oxalate stone risk.

MP01-16 METABOLIC SYNDROME INCREASES THE RISK FOR CALCIUM OXALATE STONE FORMATION: RESULTS FROM A NATIONWIDE SURVEY ON UROLITHIASIS IN JAPAN

2017 ◽  
Vol 197 (4S) ◽  
Author(s):  
Akinori Iba ◽  
Yasuo Kohjimoto ◽  
Takashi Iguchi ◽  
Shimpei Yamashita ◽  
Satoshi Nishizawa ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Calcium Oxalate ◽  
Stone Formation ◽  
Nationwide Survey ◽  
Calcium Oxalate Stone
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