Effect of Naloxone on Oxidative Stress and Testicular Injury due to Spermatic Vessel Ligation of Rat Testis

2008 ◽  
Vol 81 (3) ◽  
pp. 279-284 ◽  
Author(s):  
Murat Cakan ◽  
Demet Yilmazer ◽  
Turkay Cakan ◽  
Tolga R. Aydos ◽  
Elmas Ogus ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Rat Testis ◽  
Testicular Injury ◽  
Spermatic Vessel ◽  
Vessel Ligation

scholarly journals Altered Expression of DAAM1 and PREP Induced by Cadmium Toxicity Is Counteracted by Melatonin in the Rat Testis

Genes ◽  
2021 ◽  
Vol 12 (7) ◽  
pp. 1016
Author(s):  
Massimo Venditti ◽  
Mariem Ben Rhouma ◽  
Maria Zelinda Romano ◽  
Imed Messaoudi ◽  
Russel J. Reiter ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cadmium Toxicity ◽  
Steroidogenic Enzymes ◽  
Sod Activity ◽  
Altered Expression ◽  
Rat Testis ◽  
Adult Rat ◽  
Testicular Cells ◽  
Associated Proteins ◽  
Testicular Injury

Cadmium (Cd) is one of the most toxic pollutants for health due to its accumulation in several tissues, including testis. This report confirms that Cd increased oxidative stress and apoptosis of germ and somatic cells and provoked testicular injury, as documented by biomolecular and histological alterations, i.e., CAT and SOD activity, the protein level of steroidogenic enzymes (StAR and 3β-HSD), and morphometric parameters. Additionally, it further documents the melatonin (MLT) coadministration produces affects in mitigating Cd-induced toxicity on adult rat testis, as demonstrated by the reduction of oxidative stress and apoptosis, with reversal of the observed histological changes; moreover, a role of MLT in partially restoring steroidogenic enzymes expression was evidenced. Importantly, the cytoarchitecture of testicular cells was perturbed by Cd exposure, as highlighted by impairment of the expression and localization of two cytoskeleton-associated proteins DAAM1 and PREP, which are involved in the germ cells’ differentiation into spermatozoa, altering the normal spermatogenesis. Here, for the first time, we found that the co-treatment with MLT attenuated the Cd-induced toxicity on the testicular DAAM1 and PREP expression. The combined findings provide additional clues about a protective effect of MLT against Cd-induced testicular toxicity by acting on DAAM1 and PREP expression, encouraging further studies to prove its effectiveness in human health.

The effect of spermatic vessel ligation on testicular nitric oxide levels and germ cell-specific apoptosis in rat testis

2005 ◽  
Vol 106 (6) ◽  
pp. 459-466 ◽  
Author(s):  
Fatma Taneli ◽  
Seda Vatansever ◽  
Cevval Ulman ◽  
Ömer Yılmaz ◽  
Gülşen Giray ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Germ Cell ◽  
Rat Testis ◽  
Spermatic Vessel ◽  
Vessel Ligation

Effect of Human Chorionic Gonadotropin Before Spermatic Vessel Ligation in the Prepubertal Rat Testis

1995 ◽  
Vol 154 (2) ◽  
pp. 738-740 ◽  
Author(s):  
David A. Levy ◽  
Fadi W. Abdul-Karim ◽  
Floro Miraldi ◽  
Jack S. Elder
Keyword(s):  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Rat Testis ◽  
Spermatic Vessel ◽  
Vessel Ligation

Alterations in Oxidative Stress-Related Parameters in Rat Testis Following Monensin Administration

2006 ◽  
Vol 16 (6) ◽  
pp. 307-312 ◽  
Author(s):  
Malti Singh ◽  
N. R. Kalla ◽  
S. S. Kanwar ◽  
S. N. Sanyal
Keyword(s):  
Oxidative Stress ◽  
Rat Testis

Berberine inhibits the ischemia-reperfusion induced testicular injury through decreasing oxidative stress

2020 ◽  
Vol 38 (1) ◽  
pp. 33-37 ◽  
Author(s):  
Ilke Onur Kazaz ◽  
Ahmet Mentese ◽  
Selim Demir ◽  
Gokcen Kerimoglu ◽  
Fatih Colak ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Ischemia Reperfusion ◽  
Testicular Injury
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