Loss of Immunorecessive Cytotoxic T Lymphocyte Determinant V on SV40 T Antigen following Cocultivation with Site-Specific Cytotoxic T Lymphocyte Clone Y-5

Intervirology ◽  
1990 ◽  
Vol 31 (2-4) ◽  
pp. 197-202 ◽  
Author(s):  
Yuetsu Tanaka ◽  
Satvir S. Tevethia
Keyword(s):  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
T Antigen ◽  
Sv40 T Antigen ◽  
Site Specific ◽  
Lymphocyte Clone

Clustering of antigenic sites recognized by cytotoxic T lymphocyte clones in the amino terminal half of SV40 T antigen

Virology ◽  
1988 ◽  
Vol 162 (2) ◽  
pp. 427-436 ◽  
Author(s):  
Yuetsu Tanaka ◽  
Mary J. Tevethia ◽  
Daniel Kalderon ◽  
Alan E. Smith ◽  
Satvir S. Tevethia
Keyword(s):  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
T Antigen ◽  
Sv40 T Antigen ◽  
Amino Terminal ◽  
Antigenic Sites

Localization of an immunorecessive epitope on SV40 T antigen by H-2Db-restricted cytotoxic T-lymphocyte clones and a synthetic peptide

Virology ◽  
1989 ◽  
Vol 171 (1) ◽  
pp. 205-213 ◽  
Author(s):  
Yuetsu Tanaka ◽  
Robert W. Anderson ◽  
W. Lee Maloy ◽  
Satvir S. Tevethia
Keyword(s):  
T Lymphocyte ◽  
Synthetic Peptide ◽  
Cytotoxic T Lymphocyte ◽  
T Antigen ◽  
Sv40 T Antigen

scholarly journals Site-specific binding of wild-type p53 to cellular DNA is inhibited by SV40 T antigen and mutant p53.

1992 ◽  
Vol 6 (10) ◽  
pp. 1886-1898 ◽  
Author(s):  
J Bargonetti ◽  
I Reynisdottir ◽  
P N Friedman ◽  
C Prives
Keyword(s):  
Specific Binding ◽  
T Antigen ◽  
Mutant P53 ◽  
Wild Type ◽  
Sv40 T Antigen ◽  
Site Specific ◽  
Wild Type P53 ◽  
Cellular Dna

Dynamic changes in viscoelastic properties in cytotoxic T-lymphocyte-mediated killing

1988 ◽  
Vol 91 (2) ◽  
pp. 179-189 ◽  
Author(s):  
K.L. Sung ◽  
L.A. Sung ◽  
M. Crimmins ◽  
S.J. Burakoff ◽  
S. Chien
Keyword(s):  
T Lymphocyte ◽  
Target Cell ◽  
Viscoelastic Properties ◽  
Cytotoxic T Lymphocyte ◽  
Cell Swelling ◽  
Initial Increase ◽  
Target Cells ◽  
Dynamic Changes ◽  
Lymphocyte Clone ◽  
Membrane Cell

The biophysical properties of cytotoxic T lymphocytes during the killing of their target cells was investigated by using a human cytotoxic T lymphocyte clone, F1, and the target cell, JY, for which it is specific. In single cytotoxic cell/target cell pairs after their conjugation there are changes in the viscoelastic properties of the target cell in association with the lethal hit delivery and post-binding cytolytic steps. On the basis of these changes in the target cell, the complex cytolytic event can be divided into stages: the viscoelastic coefficients exhibited an initial increase followed by a return to resting values; thereafter these coefficients decreased below control and then rose again prior to lysis. The eventual killing of the target cell involves bubbling and swelling of the nucleus, clustering of granules, damage to the cytoplasmic membrane, cell swelling, and lysis. The viscoelastic changes involved in target cell death suggest the loss of integrity of its cytoskeletal apparatus.

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