Antiviral Activity of CP-20,961 against Herpes Simplex Viruses in vitro

Intervirology ◽  
1985 ◽  
Vol 23 (1) ◽  
pp. 44-50 ◽  
Author(s):  
Z.M. Zheng ◽  
D.R. Mayo ◽  
C.K.Y. Fong ◽  
T. Winship ◽  
G.D. Hsiung
Keyword(s):  
Herpes Simplex ◽  
Antiviral Activity ◽  
Herpes Simplex Viruses

Antiviral Activity of Eight Commonly Used Medicinal Plants in Taiwan

2003 ◽  
Vol 31 (06) ◽  
pp. 897-905 ◽  
Author(s):  
Lien-Chai Chiang ◽  
Hua-Yew Cheng ◽  
Mei-Chi Liu ◽  
Wen Chiang ◽  
Chun-Ching Lin
Keyword(s):  
Natural Products ◽  
Herpes Simplex ◽  
Medicinal Plants ◽  
Antiviral Activity ◽  
Antiviral Agents ◽  
Hot Water ◽  
Herpes Simplex Viruses ◽  
Water Extracts

In an effort to find new antiviral agents from natural products, hot water extracts of eight traditionally used medicinal plants in Taiwan were investigated in vitro for their activities against adenoviruses (ADV) and herpes simplex viruses (HSV). Results demonstrated that all extracts exhibited antiviral activity with different degrees of potency. Only two extracts were active in suppressing both HSV and ADV infections. Three extracts inhibited only ADV infection whereas one extract blocked only HSV infection. These results suggested that the aforementioned medicinal plants merit further investigation.

scholarly journals In vitro antiviral activity of BanLec against herpes simplex viruses type 1 and 2

2020 ◽  
Vol 15 (1) ◽  
pp. 11-18
Author(s):  
Arisha Taj Mahaboob Batcha ◽  
Ashish Wadhwani ◽  
Gowri Subramaniam
Keyword(s):  
Herpes Simplex ◽  
Antiviral Activity ◽  
Selectivity Index ◽  
Antiviral Compound ◽  
Herpes Simplex Viruses ◽  
Antiviral Activities ◽  
Simplex Virus ◽  
Hsv 1

The present study evaluates the antiviral activity of banana lectin (BanLec) against herpes simplex virus type 1 and 2 (HSV-1 and HSV-2). Lectin was isolated from the ripen pulp of bananas (Musa paradisiaca). The study showed that lectin exhibited hemagglutination activity towards human erythrocytes A, B, AB and O group. The molecular weight of BanLec using SDS gel-electrophoresis was found to be 14,000-30,000 Da. Cytotoxicity of BanLec on the Vero cell lines showed an inhibitory concentration of 172.7 µg/mL. BanLec was virucidal and showed no cytotoxicity at the concentration tested. The lectin showed a dose-dependent antiviral activities, inhibiting HSV-1 by 16.0 µg/mL with selectivity index 10.8 and HSV-2 inhibition by 67.7 µg/mL with selectivity index 2.6. These results corroborate that BanLec could be a rich source of potential antiviral compound for HSV-1 when compared to HSV-2.

5-Alkynyl Pyrimidine Nucleosides as Potent Selective Inhibitors of Varicella-Zoster Virus

1992 ◽  
Vol 3 (5) ◽  
pp. 293-297 ◽  
Author(s):  
S. G. Rahim ◽  
N. Trevidi ◽  
J. Selway ◽  
G. Darby ◽  
P. Collins ◽  
...  
Keyword(s):  
Herpes Simplex ◽  
Antiviral Activity ◽  
Varicella Zoster Virus ◽  
Vero Cells ◽  
In Vitro Activity ◽  
Herpes Simplex Viruses ◽  
Varicella Zoster ◽  
Pyrimidine Nucleosides ◽  
Highly Active

A series of 5-alkynyl substituted 2′-deoxyuridine and β-D-arabinofuranosyluracil nucleosides were synthesized and evaluated for in vitro activity against varicella-zoster virus (VZV). Three promising analogues, 1-(β-D-arabinofuranosyl)-5-ethynyluracil (EYaraU), 2′-deoxy-5-prop-1-ynyluridine (PYdU) and 1-(β-D-arabinof uranosyl)-5-prop-1-ynyluracil (PYaraU) had potent activity against eight strains of VZV with IC50 values averaging 1 μM. This activity was selective for VZV as the compounds were significantly less active against herpes simplex viruses (HSV) and human cytomegalovirus (HCMV) in contrast to 2′-deoxy-5-ethynyluridine (EYdU) which is highly active against all three viruses. The ability of these compounds to inhibit the growth of Vera or MRC-5 cells was over 2 orders of magnitude less than their antiviral activity (CC50 in Vero cells 350 μM for EYaraU and >500 μM for PYdU and PYaraU and >500 μM for all 3 compounds in MRC-5 cells). Direct comparative studies showed these compounds to be more potent and more selective than acyclovir (ACV).

scholarly journals Antiviral Activity of the G-Quadruplex Ligand TMPyP4 against Herpes Simplex Virus-1

Viruses ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 196
Author(s):  
Sara Artusi ◽  
Emanuela Ruggiero ◽  
Matteo Nadai ◽  
Beatrice Tosoni ◽  
Rosalba Perrone ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Dna Replication ◽  
Herpes Simplex ◽  
Antiviral Activity ◽  
Herpes Simplex Virus 1 ◽  
Tem Analysis ◽  
Infected Cells ◽  
Simplex Virus ◽  
Hsv 1

The herpes simplex virus 1 (HSV-1) genome is extremely rich in guanine tracts that fold into G-quadruplexes (G4s), nucleic acid secondary structures implicated in key biological functions. Viral G4s were visualized in HSV-1 infected cells, with massive virus cycle-dependent G4-formation peaking during viral DNA replication. Small molecules that specifically interact with G4s have been shown to inhibit HSV-1 DNA replication. We here investigated the antiviral activity of TMPyP4, a porphyrin known to interact with G4s. The analogue TMPyP2, with lower G4 affinity, was used as control. We showed by biophysical analysis that TMPyP4 interacts with HSV-1 G4s, and inhibits polymerase progression in vitro; in infected cells, it displayed good antiviral activity which, however, was independent of inhibition of virus DNA replication or entry. At low TMPyP4 concentration, the virus released by the cells was almost null, while inside the cell virus amounts were at control levels. TEM analysis showed that virus particles were trapped inside cytoplasmatic vesicles, which could not be ascribed to autophagy, as proven by RT-qPCR, western blot, and immunofluorescence analysis. Our data indicate a unique mechanism of action of TMPyP4 against HSV-1, and suggest the unprecedented involvement of currently unknown G4s in viral or antiviral cellular defense pathways.

scholarly journals In vitro antiviral activity of antimicrobial peptides against herpes simplex virus 1, adenovirus, and rotavirus

2007 ◽  
Vol 102 (4) ◽  
pp. 469-472 ◽  
Author(s):  
Márcia Cristina Carriel-Gomes ◽  
Jadel Müller Kratz ◽  
Margherita Anna Barracco ◽  
Evelyne Bachére ◽  
Célia Regina Monte Barardi ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Antiviral Activity ◽  
Antimicrobial Peptides ◽  
Herpes Simplex Virus 1 ◽  
Simplex Virus

scholarly journals ON THE ROLE OF RIBONUCLEIC ACID IN ANIMAL VIRUS SYNTHESIS

1960 ◽  
Vol 111 (3) ◽  
pp. 351-368 ◽  
Author(s):  
Igor Tamm ◽  
Rostom Bablanian
Keyword(s):  
Herpes Simplex ◽  
Vaccinia Virus ◽  
Ribonucleic Acid ◽  
Chorioallantoic Membrane ◽  
Host Cells ◽  
Active Inhibitor ◽  
Herpes Simplex Viruses ◽  
Virus Particles ◽  
Highly Active

Ribonuclease is a highly active inhibitor of vaccinia virus multiplication in vitro in the chorioallantoic membrane removed from embryonated chicken eggs. It is also a highly active inhibitor of pock formation by vaccinia and herpes simplex viruses on the chorioallantoic membrane in vivo. Marked inhibitory effects were obtained with 12.5 µg. of RNase. However, complete inhibition was not obtained with several hundred micrograms of the enzyme. RNase caused no inactivation of the infectivity of vaccinia virus particles but it had a marked inhibitory effect on multiplication of this virus when administered many hours after infection of host cells had occurred. RNase also failed to inactivate the infectivity of herpes simplex virus particles. The results obtained indicate that ribonucleic acid is necessary for the multiplication of two DNA-containing viruses; i.e., vaccinia and herpes simplex.

scholarly journals Antiviral activity of PHA767491 against human herpes simplex virus in vitro and in vivo

2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Jue Hou ◽  
Zili Zhang ◽  
Qiang Huang ◽  
Jun Yan ◽  
Xiaohu Zhang ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Antiviral Activity ◽  
Human Herpes ◽  
Simplex Virus
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