Multiple Distinct Antigenic Determinants Associated with Murine Type-C Virus Group-Specific Antigen

Intervirology ◽  
1973 ◽  
Vol 2 (5-6) ◽  
pp. 326-336 ◽  
Author(s):  
James Davis ◽  
Howard P. Charman ◽  
Stephen Oroszlan ◽  
Raymond V. Gilden
Keyword(s):  
Specific Antigen ◽  
Antigenic Determinants ◽  
Virus Group ◽  
Type C

A rapid direct radioimmunoassay for type C virus group-specific antigen and antibody

Virology ◽  
1972 ◽  
Vol 50 (1) ◽  
pp. 294-296 ◽  
Author(s):  
Stephen Oroszlan ◽  
Martin M.H. White ◽  
Raymond V. Gilden ◽  
Howard P. Charman
Keyword(s):  
Specific Antigen ◽  
Virus Group ◽  
Type C

scholarly journals Variability and Immunogenicity of Caprine Arthritis-Encephalitis Virus Surface Glycoprotein

2000 ◽  
Vol 74 (13) ◽  
pp. 6178-6185 ◽  
Author(s):  
S. Valas ◽  
C. Benoit ◽  
C. Baudry ◽  
G. Perrin ◽  
R. Z. Mamoun
Keyword(s):  
Phylogenetic Analyses ◽  
Natural Infection ◽  
Specific Antigen ◽  
Encephalitis Virus ◽  
Surface Glycoprotein ◽  
Antigenic Determinants ◽  
Virus Infections ◽  
Virus Surface ◽  
Caprine Arthritis Encephalitis Virus ◽  
Variable Domains

ABSTRACT The complete surface glycoprotein (SU) nucleotide sequences of three French isolates of caprine arthritis-encephalitis virus (CAEV) were determined and compared with those of previously described isolates: three American isolates and one French isolate. Phylogenetic analyses revealed the existence of four distinct and roughly equidistant evolutionary CAEV subtypes. Four conserved and five variable domains were identified in the SU. The fine specificities of antibodies produced against these domains during natural infection were examined using a pepscan analysis. Nine immunogenic segments were delineated throughout the conserved and variable domains of SU, two of them corresponding to conserved immunodominant epitopes. Antigenic determinants which may be involved in the immunopathogenic process induced by CAEV were identified. These results also provide sensitive and specific antigen peptides for the serological detection and differentiation of CAEV and visna/maedi virus infections.

Murine Leukaemia Virus Group-specific Antigen in the C-Type Virus-containing Human Cell Line, ESP-1

Nature ◽  
1971 ◽  
Vol 233 (5315) ◽  
pp. 102-103 ◽  
Author(s):  
RAYMOND V. GILDEN ◽  
WADE P. PARKS ◽  
ROBERT J. HUEBNER ◽  
GEORGE J. TODARO
Keyword(s):  
Cell Line ◽  
Human Cell ◽  
Specific Antigen ◽  
Human Cell Line ◽  
Type Virus ◽  
Leukaemia Virus ◽  
Virus Group ◽  
Murine Leukaemia Virus

The host-tissue component of influenza viruses

1955 ◽  
Vol 143 (913) ◽  
pp. 504-522 ◽  
Keyword(s):  
Specific Antigen ◽  
Cross Reactivity ◽  
Host Tissue ◽  
Influenza Viruses ◽  
Tissue Component ◽  
Cross Reactions ◽  
Virus Group ◽  
Heat Degradation ◽  
Specific Antigens ◽  
Determinant Function

Serological cross-reactions between influenza viruses of the two major types A and B and between the viruses and extracts of host tissue were investigated to elucidate the nature and source of the antigens concerned. The results render untenable the generally accepted view that virus types A and B are totally unrelated antigenically and that any cross-reactivity which occurs must be due to impurities in the virus preparations used. Strong cross-complement fixation reactions were consistently demonstrable with highly purified viruses provided that the antisera were prepared by immunizing rabbits with heat-degraded viruses in which the specific antigens had been destroyed. Cross-reactions between the viruses and chorio-allantoic membrane extracts showed that the virus-group antigens differed from the dominant membrane antigen which is of the Forssman type. The cross-reacting antigens of the two viruses were also found to be distinguishable from each other by their different responses to heat degradation. With the classical strains PR 8 and Lee propagated in embryonated eggs, the virus-group antigen could not be removed by successive cycles of virus purification. The method of purification was adsorption of virus on human group O red cells followed by spontaneous elution effected by the receptor-destroying enzyme of the virus. The ratio of specific antigen to group antigen remained constant through six successive purification cycles. It is suggested that the host-tissue component of the viruses is an integral part of their structure which may be essential for virus synthesis and may have some determinant function in respect of virus behaviour. The possibility of its fortuitous inclusion within the virus matrix without serving any biological purpose has not been excluded, but in such case its presence would point to a replication mechanism different from simple binary fission.

scholarly journals Radioimmunoassay for Avian C-Type Virus Group-Specific Antigen: Detection in Normal and Virus-Transformed Cells

1973 ◽  
Vol 11 (6) ◽  
pp. 893-899 ◽  
Author(s):  
John R. Stephenson ◽  
Roger E. Wilsnack ◽  
Stuart A. Aaronson
Keyword(s):  
Specific Antigen ◽  
Antigen Detection ◽  
Transformed Cells ◽  
Type Virus ◽  
Virus Group

scholarly journals Antigenic determinants of prostate-specific antigen (PSA) and development of assays specific for different forms of PSA

1997 ◽  
Vol 75 (6) ◽  
pp. 789-797 ◽  
Author(s):  
O Nilsson ◽  
A Peter ◽  
I Andersson ◽  
K Nilsson ◽  
B Grundström ◽  
...  
Keyword(s):  
Prostate Specific Antigen ◽  
Specific Antigen ◽  
Antigenic Determinants
Sign in / Sign up

Export Citation Format

Share Document