A Sensitive Method for the Detection of Herpes Simplex Virus Type 2 Specific Thymidine Kinase

Intervirology ◽  
1977 ◽  
Vol 8 (3) ◽  
pp. 186-192 ◽  
Author(s):  
Jan.M.M. Walboomers ◽  
Ruud van Ketel ◽  
Mies J. Becker-Bloemkolk
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Thymidine Kinase ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Simplex Virus ◽  
Sensitive Method

Inability to rescue viral genes from human cells biochemically transformed by herpes simplex virus type 2 DNA

1981 ◽  
Vol 27 (10) ◽  
pp. 1123-1128 ◽  
Author(s):  
José Campione-Piccardo ◽  
William E. Rawls
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Thymidine Kinase ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Human Cells ◽  
Viral Genes ◽  
Simplex Virus ◽  
Hsv 1

Thymidine kinase negative (TK−) mutants of HSV-1 were used to attempt to rescue HSV-2 genes from cells biochemically transformed with HSV-2 DNA. The results indicate that the occurrence of a rescue event was less than 7 × 10−7 in this system.

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