Immunohistochemical Studies on GABAergic Neurons in the Rat Locus coeruleus, with Special Reference to Their Relationship to Astrocytes

1987 ◽  
Vol 129 (2) ◽  
pp. 116-122 ◽  
Author(s):  
Koichi Iijima ◽  
Ryoji Kobayashi ◽  
Naosuke Kojima
Keyword(s):  
Special Reference ◽  
Locus Coeruleus ◽  
Gabaergic Neurons ◽  
Immunohistochemical Studies

Immunohistochemical studies on the distribution of nerve fibers in the human prostate with special reference to the anterior fibromuscular stroma

The Prostate ◽  
2001 ◽  
Vol 48 (4) ◽  
pp. 242-247 ◽  
Author(s):  
Tsuyoshi Iwata ◽  
Osamu Ukimura ◽  
Mitsuhiko Inaba ◽  
Munekado Kojima ◽  
Kenzo Kumamoto ◽  
...  
Keyword(s):  
Special Reference ◽  
Nerve Fibers ◽  
Human Prostate ◽  
Immunohistochemical Studies

scholarly journals Active control of arousal by a locus coeruleus GABAergic circuit

2018 ◽  
Author(s):  
Vincent Breton-Provencher ◽  
Mriganka Sur
Keyword(s):  
Prefrontal Cortex ◽  
Locus Coeruleus ◽  
Cognitive Performance ◽  
Active Control ◽  
Local Population ◽  
Gabaergic Neurons ◽  
The Other ◽  
Lc Circuit ◽  
Virus Tracing ◽  
The Brain

AbstractArousal and novelty responses linked to locus coeruleus noradrenergic (LC-NA) activity affect cognitive performance. However, the mechanisms that control modes of LC-NA activity remain unknown. Here, we reveal a local population of GABAergic neurons (LC-GABA) capable of modulating LC-NA activity and arousal. Monosynaptic retrograde virus tracing shows that inputs to LC-GABA and LC-NA neurons arise from similar regions, though a few regions provide differential inputs to one subtype over the other. Recordings in the LC demonstrate two modes of LC-GABA responses whereby spiking is either correlated or broadly anti-correlated with LC-NA responses, reflecting anatomically similar and functionally coincident inputs, or differential and non-coincident inputs, to LC-NA and LC-GABA neurons. Coincident inputs control the gain of phasic LC-NA mediated novelty responses, while non-coincident inputs, such as from the prefrontal cortex to LC, alter overall levels of LC-NA responses without affecting response gain. These findings demonstrate distinct modes by which an inhibitory LC circuit regulates the gain and tone of arousal in the brain.

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