Pure 46,XY Gonadal Dysgenesis (Swyer Syndrome) with Breast Development and Secondary Amenorrhea

2008 ◽  
Vol 66 (3) ◽  
pp. 214-216 ◽  
Author(s):  
Erdin İlter ◽  
Berna Haliloğlu ◽  
Figen Temelli Akın ◽  
Arzu Karaman ◽  
Selçuk Özden
Keyword(s):  
Gonadal Dysgenesis ◽  
Breast Development ◽  
Secondary Amenorrhea ◽  
Xy Gonadal Dysgenesis ◽  
Swyer Syndrome

scholarly journals Successful Conception and Delivery in an Unusual Case of 46,XY Pure Gonadal Dysgenesis with Spontaneous Breast Development, Menses, and Bilateral Hydrosalpinx

2016 ◽  
Vol 7 (2) ◽  
pp. 58-60
Author(s):  
Kishore Nadkarni
Keyword(s):  
Pregnancy Outcome ◽  
Gonadal Dysgenesis ◽  
Unusual Case ◽  
Breast Development ◽  
Secondary Amenorrhea ◽  
Primary Infertility ◽  
Secondary Sexual Characters ◽  
Endometrial Preparation ◽  
Swyer Syndrome

Abstract Aim To study unusual presentations of 46XY pure gonadal dysgenesis (Swyer syndrome), implications of delayed diagnosis, importance of karyotype and early gonadectomy and pregnancy outcome with ART. Background To report a case of Swyer syndrome with spontaneous breast development, menses and bilateral hydrosalpinx with Successful pregnancy outcome. Case description 30 years old lady presented with primary infertility, secondary amenorrhea and normal secondary sexual characters. Sonography revealed small uterus with atrophic ovaries and B/L hydrosalpinx. Hormonal profile showed hypergonadotrophic hypogonadism and Karyotype was 46XY. Laparoscopic salpingectomy and gonadectomy was done. Histopathology revealed streak gonads with no evidence of malignancy and diagnosis of 46XY disorder of sexual development (DSD)/ Swyer syndrome was made. After endometrial preparation with ethinyl estradiol, patient conceived with allogenic oocytes and delivered preterm twins vaginally at 31 weeks. Conclusion Patients with Swyer Syndrome usually present at adolescence with delayed puberty and/or primary amenorrhea. However they can present late with secondary amenorrhea or just irregular, infrequent menses or primary infertility. Karyotype is mandatory in such cases and early gonadectomy improves long term survival as incidence of malignancy in the dysgenetic gonad is high. Incipient malignancy is usually the source of estrogen in patients with normal secondary sexual characters. Hypoplastic uterus is responsive to estrogen therapy in terms of enlargement and endometrial preparation and also this uterus may have the ability to respond to the process of labor and these patients can deliver vaginally. Clinical significance Early diagnosis and timely management of patients with dysgenetic gonads is important. Pregnancy is possible with allogenic oocytes. Genetic counseling and long term follow-up is required. How to cite this article Singh P, Kalra A, Nadkarni PK, Nadkarni K. Successful Conception and Delivery in an Unusual Case of 46,XY Pure Gonadal Dysgenesis with Spontaneous Breast Development, Menses, and Bilateral Hydrosalpinx. Int J Infertil Fetal Med 2016;7(2):58-60.

scholarly journals Swyer Syndrome

2020 ◽  
Vol 11 (3) ◽  
pp. 65-68
Author(s):  
G. R. Gazizova ◽  
F. V. Valeeva ◽  
M. R. Shaydullina ◽  
E. I. Akbirova
Keyword(s):  
Gonadal Dysgenesis ◽  
Clinical Observation ◽  
Clinical Symptoms ◽  
Objective Data ◽  
Xy Gonadal Dysgenesis ◽  
Swyer Syndrome ◽  
Swyer’S Syndrome

A clinical observation of a patient with Swyer's syndrome is presented. The article presents anamnesis data, phenotypic signs, clinical symptoms and objective data of the patient, the results of instrumental and hormonal studies, on the basis of which doctors of different specialties may suspect a violation of sex formation with XY gonadal dysgenesis.

A POSSIBLE EXPLANATION FOR SPONTANEOUS BREAST DEVELOPMENT IN XY GONADAL DYSGENESIS

1973 ◽  
Vol 28 (7) ◽  
pp. 506-508
Author(s):  
J. M. CANTU ◽  
E. OLIVERA ◽  
D. GONZALEZ ◽  
F. HIDALGO ◽  
M. GONZALEZ ◽  
...  
Keyword(s):  
Gonadal Dysgenesis ◽  
Breast Development ◽  
Xy Gonadal Dysgenesis

46, XY Gonadal Dysgenesis With Secondary Amenorrhea, Virilization, and Bilateral Gonadoblastomas

1979 ◽  
Vol 72 (9) ◽  
pp. 1163-1165 ◽  
Author(s):  
BASSAM Y. BARAKAT ◽  
I. G. ANCES ◽  
C. K. TANG ◽  
ABRAM B. FAJER
Keyword(s):  
Gonadal Dysgenesis ◽  
Secondary Amenorrhea ◽  
Xy Gonadal Dysgenesis

Swyer Syndrome/46 XY Gonadal Dysgenesis: Remove the Tubes or Not?

2021 ◽  
Vol 34 (6) ◽  
pp. 771-772 ◽  
Author(s):  
Mary E. Fallat ◽  
Paige Hertweck ◽  
Sigal Klipstein
Keyword(s):  
Gonadal Dysgenesis ◽  
Xy Gonadal Dysgenesis ◽  
Swyer Syndrome

H-Y antigen in Swyer syndrome and the genetics of XY gonadal dysgenesis

1979 ◽  
Vol 53 (1) ◽  
pp. 51-56 ◽  
Author(s):  
C. A. Moreira-Filho ◽  
S. P. A. Toledo ◽  
V. R. Bagnolli ◽  
O. Frota-Pessoa ◽  
H. Bisi ◽  
...  
Keyword(s):  
Gonadal Dysgenesis ◽  
Xy Gonadal Dysgenesis ◽  
Swyer Syndrome
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