Comparative studies on the histochemical features of ovarian compartments in the rat and golden hamster, with special reference to steroid hormone synthesis

1972 ◽  
Vol 82 (2) ◽  
pp. 284-304 ◽  
Author(s):  
Sardul S. Guraya
Keyword(s):  
Special Reference ◽  
Golden Hamster ◽  
Comparative Studies ◽  
Steroid Hormone ◽  
Hormone Synthesis

miR-130a-3p regulates steroid hormone synthesis in goat ovarian granulosa cells by targeting the PMEPA1 gene

2021 ◽  
Vol 165 ◽  
pp. 92-98
Author(s):  
Lu Zhu ◽  
Jing Jing ◽  
Shuaiqi Qin ◽  
Qi Zheng ◽  
Jiani Lu ◽  
...  
Keyword(s):  
Granulosa Cells ◽  
Steroid Hormone ◽  
Hormone Synthesis ◽  
Ovarian Granulosa Cells

THE PHARMACOLOGY OF THE RAUWOLFIA ALKALOIDS CHANDRINE AND SERPAKRINE

1960 ◽  
Vol 38 (1) ◽  
pp. 889-897
Author(s):  
A. K. Reynolds ◽  
H. J. Presutti ◽  
D. P. MacLeod
Keyword(s):  
Smooth Muscle ◽  
Special Reference ◽  
Comparative Studies ◽  
Hypotensive Activity ◽  
Pharmacological Properties ◽  
Root Extracts ◽  
Cardiovascular Actions ◽  
Per Se ◽  
Ganglionic Blocking ◽  
Depressor Action

The pharmacological properties of two new alkaloids of Rauwolfia serpentina have been studied with special reference to their cardiovascular actions. In several instances, comparative studies have been carried out with the clinically used alseroxylon fraction of R. serpentina. Chandrine and serpakrine do not profoundly influence the activity or behavior of intact animals unless administered in very large doses. They are completely devoid of the tranquilizing action that characterizes such bases as reserpine and rescinnamine. They do, however, exhibit marked hypotensive activity. The mechanism of this depressor action has not been clearly established. It is not seen in spinal animals, and there is no evidence of ganglionic blocking or peripheral adrenolytic action. The effects of chandrine or serpakrine per se on smooth muscle structures are not pronounced, but antiacetylcholine activity has been observed on these and other preparations. Their contribution to the actions of the clinically employed whole-root extracts is probably not very marked.

scholarly journals Effects of ChREBP deficiency on adrenal lipogenesis and steroidogenesis

2021 ◽  
Author(s):  
Ken Takao ◽  
Katsumi Iizuka ◽  
Yanyan Liu ◽  
Teruaki Sakurai ◽  
Sodai Kubota ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Target Genes ◽  
Adrenal Glands ◽  
Plasma Cholesterol ◽  
Steroid Hormone ◽  
Acid Synthesis ◽  
Cholesterol Content ◽  
Hormone Synthesis ◽  
Corticosterone Secretion ◽  
Element Binding Protein

Carbohydrate response element binding protein (ChREBP) is critical in the regulation of fatty acid and triglyceride synthesis in the liver. Interestingly, Chrebp-/- mice show reduced levels of plasma cholesterol, which is critical for steroid hormone synthesis in adrenal glands. Furthermore, Chrebp mRNA expression was previously reported in human adrenal glands. Thus, it remains to be investigated whether ChREBP plays a role directly or indirectly in steroid hormone synthesis and release in adrenal glands. In the present study, we find that Chrebp mRNA is expressed in mouse adrenal glands and that ChREBP binds to carbohydrate response elements. Histological analysis of Chrebp-/- mice shows no adrenal hyperplasia and less oil red O staining compared with that in wild-type mice. In adrenal glands of Chrebp-/- mice, expression of Fasn and Scd1, two enzymes critical for fatty acid synthesis, was substantially lower and triglyceride content was reduced. Expression of Srebf2, a key transcription factor controlling synthesis and uptake of cholesterol and the target genes was upregulated, while cholesterol content was not significantly altered in the adrenal glands of Chrebp-/- mice. Adrenal corticosterone content and plasma adrenocorticotropic hormone and corticosterone levels were not significantly altered in Chrebp-/- mice. Consistently, expression of genes related to steroid hormone synthesis was not altered. Corticosterone secretion in response to two different stimuli, namely 24-h starvation and cosyntropin administration, were also not altered in Chrebp-/- mice. Taking these results together, corticosterone synthesis and release were not affected in Chrebp-/- mice despite reduced plasma cholesterol levels.

Effect of nutrition on plasma lipid profile and mRNA levels of ovarian genes involved in steroid hormone synthesis in Hu sheep during luteal phase1

2013 ◽  
Vol 91 (11) ◽  
pp. 5229-5239 ◽  
Author(s):  
S. J. Ying ◽  
S. H. Xiao ◽  
C. L. Wang ◽  
B. S. Zhong ◽  
G. M. Zhang ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Steroid Hormone ◽  
Plasma Lipid ◽  
Mrna Levels ◽  
Plasma Lipid Profile ◽  
Hormone Synthesis ◽  
Hu Sheep

scholarly journals Minireview: Nuclear Receptor-Controlled Steroid Hormone Synthesis and Metabolism

2010 ◽  
Vol 24 (1) ◽  
pp. 11-21 ◽  
Author(s):  
Jinhan He ◽  
Qiuqiong Cheng ◽  
Wen Xie
Keyword(s):  
Transcription Factors ◽  
Dna Binding ◽  
Steroid Hormones ◽  
Nuclear Receptor ◽  
Recent Progress ◽  
Hormone Receptors ◽  
Steroid Hormone ◽  
Etiological Factor ◽  
Hormone Synthesis

Abstract Steroid hormones are essential in normal physiology whereas disruptions in hormonal homeostasis represent an important etiological factor for many human diseases. Steroid hormones exert most of their functions through the binding and activation of nuclear hormone receptors (NRs or NHRs), a superfamily of DNA-binding and often ligand-dependent transcription factors. In recent years, accumulating evidence has suggested that NRs can also regulate the biosynthesis and metabolism of steroid hormones. This review will focus on the recent progress in our understanding of the regulatory role of NRs in hormonal homeostasis and the implications of this regulation in physiology and diseases.

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