Nonventilatory Strategies for Prevention and Treatment of Bronchopulmonary Dysplasia – What Is the Evidence?

Neonatology ◽  
2008 ◽  
Vol 94 (3) ◽  
pp. 150-159 ◽  
Author(s):  
W. Thomas ◽  
C.P. Speer
Keyword(s):  
Bronchopulmonary Dysplasia ◽  
Prevention And Treatment

scholarly journals Searching for better animal models of BPD: a perspective

2016 ◽  
Vol 311 (5) ◽  
pp. L924-L927 ◽  
Author(s):  
Namasivayam Ambalavanan ◽  
Rory E. Morty
Keyword(s):  
Animal Models ◽  
Bronchopulmonary Dysplasia ◽  
Prevention And Treatment

There have been many efforts to develop good animal models of bronchopulmonary dysplasia (BPD) to better understand the pathophysiology and mechanisms underlying development of BPD as well as to test potential strategies for its prevention and treatment. This Perspectives summarizes the features of common animal models of BPD and the strengths and limitations of such models. Potential optimal approaches to development of animal models are indicated, with the underlying concepts that require emphasis.

scholarly journals Respiratory Tract Microecology and Bronchopulmonary Dysplasia in Preterm Infants

2021 ◽  
Vol 9 ◽  
Author(s):  
Tong Sun ◽  
Haiyang Yu ◽  
Jianhua Fu
Keyword(s):  
Respiratory Tract ◽  
Microbial Diversity ◽  
Preterm Infants ◽  
Bronchopulmonary Dysplasia ◽  
Premature Infants ◽  
Respiratory Complication ◽  
Prevention And Treatment ◽  
New Ideas

Bronchopulmonary dysplasia (BPD) is a severe respiratory complication in preterm infants. Although the etiology and pathogenesis of BPD are complex and remain to be clarified, recent studies have reported a certain correlation between the microecological environment of the respiratory tract and BPD. Changes in respiratory tract microecology, such as abnormal microbial diversity and altered evolutional patterns, are observed prior to the development of BPD in premature infants. Therefore, research on the colonization and evolution of neonatal respiratory tract microecology and its relationship with BPD is expected to provide new ideas for its prevention and treatment. In this paper, we review microecological changes in the respiratory tract and the mechanisms by which they can lead to BPD in preterm infants.

scholarly journals Proteins in cord blood as a new target for prevention and treatment of bronchopulmonary dysplasia: a proteomic analysis

2021 ◽  
Author(s):  
Juan Wang ◽  
Jianping Mao ◽  
Gang Chen ◽  
Yuanmei Huang ◽  
Jinjin Zhou ◽  
...  
Keyword(s):  
Cord Blood ◽  
Signaling Pathways ◽  
Signaling Pathway ◽  
Bronchopulmonary Dysplasia ◽  
Proteomic Analysis ◽  
Mapk Signaling ◽  
Term Infants ◽  
Reproductive Process ◽  
Prevention And Treatment ◽  
Differential Proteins

Abstract This study aimed to explore the proteins in cord blood that could regulate the development of neonatal bronchi and lungs, and to find a new target for the prevention and treatment of bronchopulmonary dysplasia (BPD). In this study, proteomic analysis was used to analyze the proteins in cord blood of preterm and term infants. A total of 100 differentially expressed (57 up-regulated and 43 down-regulated) proteins were identified from preterm with BPD and term infants cord blood (fold change ≥ 1.5, P value < 0.05). GO analysis revealed that the major enrichment functions of these differential proteins were multi-organism process, stimulus, immune system process growth, reproductive process, development process and antioxidant activity. The signaling pathways involved included insulin resistance, insulin signaling pathway, IL−17 signaling pathway, PI3K−Akt signaling pathway, NF−kappa B signaling pathway, glucagon signaling pathway, apoptosis, MAPK signaling pathway, as well as glycolysis/gluconeogenesis. Further protein and protein interact (PPI) analysis revealed that the interacting proteins involved were PGAM1, CNN2, HSP90AA and DAG1, which were all crucial in the development of BPD. We found that these differential proteins in cord blood might regulate bronchopulmonary development through the abovementioned signaling pathways or their interaction proteins, which may provide a new research direction for the intervention of BPD.

Systematic Evaluation of Early Inhalation of Nitric Oxide for Prevention and Treatment of Bronchopulmonary Dysplasia in Premature Infants

2021 ◽  
Vol 7 (5) ◽  
pp. 4349-4357
Author(s):  
Yunying Yan ◽  
Guixiang Zeng ◽  
Shuwen Huang
Keyword(s):  
Nitric Oxide ◽  
Placebo Group ◽  
Clinical Practice ◽  
Bronchopulmonary Dysplasia ◽  
Premature Infants ◽  
Meta Analysis ◽  
Systematic Evaluation ◽  
Obvious Effect ◽  
Prevention And Treatment

Bronchopulmonary dysplasia (BPD) is a common chronic lung disease in premature infants, which seriously affects the quality of life of premature infants and may even lead to death of premature infants. At present, there is no unified opinion on the prevention and treatment of BPD, and the mechanism of its occurrence and development is not completely clear in clinical practice. Therefore, finding a better way to prevent and treat BPD is one of the hot spots in clinical practice. The safety of nitric oxide in premature infants with BPD is a focus of clinical attention, but its systematic evaluation has not been reported. In this study, meta-analysis method was used to analysis. The results demonstrated that there were no obvious differences in the incidence, survival, BPD-free survival, and mortality between the inhaled nitric oxide group (iNO group) and the placebo group. The common complications such as toxemia, necrotizing enterocolitis, and visual impairment between the iNO group and the placebo group were not obvious. This suggests that the use of NO to prevent BPD in premature infants has no obvious effect.

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