Magnetic Resonance Spectroscopy Performance for Detection of Dementia, Alzheimer’s Disease and Mild Cognitive Impairment in a Community-Based Survey

2008 ◽  
Vol 26 (1) ◽  
pp. 15-25 ◽  
Author(s):  
J.M. García Santos ◽  
D. Gavrila ◽  
C. Antúnez ◽  
M.J. Tormo ◽  
D. Salmerón ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Resonance Spectroscopy ◽  
Community Based

Longitudinal Functional Magnetic Resonance Spectroscopy Study in Subjects with Mild Cognitive Impairment and Alzheimer’s Disease

2021 ◽  
Vol 18 ◽  
Author(s):  
Soo-Hyun Cho ◽  
Hak Young Rhee ◽  
Janghoon Oh ◽  
Jin San Lee ◽  
Soonchan Park ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Resonance Spectroscopy ◽  
Brain Metabolites ◽  
Functional Magnetic Resonance ◽  
Longitudinal Changes ◽  
Functional Magnetic Resonance Spectroscopy

Background: Longitudinal changes of brain metabolites during a functional stimulation are unknown in amnestic mild cognitive impairment (aMCI) and Alzheimer’s disease (AD) subjects. Objective: This study was to evaluate the longitudinal changes of brain metabolites using proton magnetic resonance spectroscopy (1H MRS) in response to treatment during a memory task in the subjects of cognitive normal (CN), aMCI, and AD. Methods: We acquired functional magnetic resonance spectroscopy (fMRS) data from 28 CN elderly, 16 aMCI and 12 AD subjects during a face-name association task. We measured fMRS metabolite ratios over 24 months in the 8-month apart, determined the temporal changes of the metabolites, and evaluated the differences among the three groups under the three different conditions (base, novel, repeat). Results: The results of comparisons for the three subject groups and the three-time points showed that tNAA/tCho and tCr/tCho were statistically significant among the three subject groups in any of the three conditions. The dynamic temporal change measurements for the metabolites for each condition showed that Glx/tCho and Glu/tCho levels at the third visit increased significantly compared with in the first visit in the novel condition in the AD group. Conclusion: We found declines in tNAA/tCho and tCr/tCho in the aMCI and AD subjects with increasing disease severity, being highest in CN and lowest in AD. The Glx/tCho level increased temporally in the AD subjects after they took an acetylcholine esterase inhibitor. Therefore, Glx may be suitable to demonstrate functional recovery after treatment.

Magnetic resonance spectroscopy as a predictor of conversion of mild cognitive impairment to dementia

2013 ◽  
Vol 335 (1-2) ◽  
pp. 58-63 ◽  
Author(s):  
Magdalena G. Targosz-Gajniak ◽  
Joanna S. Siuda ◽  
Magdalena M. Wicher ◽  
Tomasz J. Banasik ◽  
Malgorzata A. Bujak ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Resonance Spectroscopy

scholarly journals Magnetic resonance spectroscopy and brain volumetry in mild cognitive impairment. A prospective study

2017 ◽  
Vol 38 ◽  
pp. 27-32 ◽  
Author(s):  
Nicolás Fayed ◽  
Pedro J. Modrego ◽  
Gracián García-Martí ◽  
Roberto Sanz-Requena ◽  
Luis Marti-Bonmatí
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Prospective Study ◽  
Resonance Spectroscopy ◽  
Brain Volumetry ◽  
A Prospective Study
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