Differences in Anesthetic Potency between Sprague-Dawley and Long-Evans Rats for Isof lurane but Not Nitrous Oxide

Pharmacology ◽  
1995 ◽  
Vol 50 (3) ◽  
pp. 162-167 ◽  
Author(s):  
Garfield B. Russell ◽  
John M. Graybeal
Author(s):  
D. J. McComb ◽  
J. Beri ◽  
F. Zak ◽  
K. Kovacs

Investigation of the spontaneous pituitary adenomas in rat have been limited mainly to light microscopic study. Furth et al. (1973) described them as chromophobic, secreting prolactin. Kovacs et al. (1977) in an ul trastructural investigation of adenomas of old female Long-Evans rats, found that they were composed of prolactin cells. Berkvens et al. (1980) using immunocytochemistry at the light microscopic level, demonstrated that some spontaneous tumors of old Wistar rats could contain GH, TSH or ACTH as well as PRL.


1998 ◽  
Vol 804 (2) ◽  
pp. 316-319 ◽  
Author(s):  
Michael H Baumann ◽  
Judith M Horowitz ◽  
Mark B Kristal ◽  
German Torres

1998 ◽  
Vol 45 (2) ◽  
pp. 162-173 ◽  
Author(s):  
Li You ◽  
Mercedes Casanova ◽  
Shannon Archibeque-Engle ◽  
Madhabananda Sar ◽  
Li-Qun Fan ◽  
...  

2012 ◽  
Vol 2012 ◽  
pp. 1-15 ◽  
Author(s):  
Toco Y. P. Chui ◽  
David Bissig ◽  
Bruce A. Berkowitz ◽  
James D. Akula

Although retinopathy of prematurity (ROP) is clinically characterized by abnormal retinal vessels at the posterior pole of the eye, it is also commonly characterized by vascular abnormalities in the anterior segment, visual dysfunction which is based in retinal dysfunction, and, most commonly of all, arrested eye growth and high refractive error, particularly (and paradoxically) myopia. The oxygen-induced retinopathy rat model of ROP presents neurovascular outcomes similar to the human disease, although it is not yet known if the “ROP rat” also models the small-eyed myopia characteristic of ROP. In this study, magnetic resonance images (MRIs) of albino (Sprague-Dawley) and pigmented (Long-Evans) ROP rat eyes, and age- and strain-matched room-air-reared (RAR) controls, were examined. The positions and curvatures of the various optical media were measured and the refractive state (℞) of each eye estimated based on a previously published model. Even in adulthood (postnatal day 50), Sprague-Dawley and Long-Evans ROP rats were significantly myopic compared to strain-matched controls. The myopia in the Long-Evans ROP rats was more severe than in the Sprague-Dawley ROP rats, which also had significantly shorter axial lengths. These data reveal the ROP rat to be a novel and potentially informative approach to investigating physiological mechanisms in myopia in general and the myopia peculiar to ROP in particular.


2005 ◽  
Vol 227 (4) ◽  
pp. 575-578 ◽  
Author(s):  
Mads F. Bertelsen ◽  
Craig A. E. Mosley ◽  
Graham J. Crawshaw ◽  
Doris H. Dyson ◽  
Dale A. Smith

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