Human Liver Cytochrome P-450 Related to a Rat Acetone-Inducible, Nitrosamine-Metabolizing Cytochrome P-450: Identification and Isolation

Pharmacology ◽  
1989 ◽  
Vol 39 (3) ◽  
pp. 137-144 ◽  
Author(s):  
Richard C. Robinson ◽  
Robert G.L. Shorr ◽  
Angela Varrichio ◽  
Sang S. Park ◽  
Harry V. Gelboin ◽  
...  
Keyword(s):  
Human Liver ◽  
Liver Cytochrome ◽  
Cytochrome P 450

Purification of Human Liver Cytochrome P-450 Catalyzing Testosterone 6β-Hydroxylation1

1987 ◽  
Vol 102 (3) ◽  
pp. 493-501 ◽  
Author(s):  
Sumie KAWANO ◽  
Tetsuya KAMATAKI ◽  
Toshio YASUMORI ◽  
Yasushi YAMAZOE ◽  
Ryuichi KATO
Keyword(s):  
Human Liver ◽  
Liver Cytochrome ◽  
Cytochrome P 450

Partial purification of human liver cytochrome P 450

1979 ◽  
Vol 88 (3) ◽  
pp. 826-832 ◽  
Author(s):  
Ph. Beaune ◽  
P. Dansette ◽  
J.P. Flinois ◽  
S. Columelli ◽  
D. Mansuy ◽  
...  
Keyword(s):  
Human Liver ◽  
Partial Purification ◽  
Liver Cytochrome ◽  
Cytochrome P 450

Anti-human liver cytochrome P-450 IA2 antibodies in patients with dihydralazine hepatitis

1990 ◽  
Vol 11 ◽  
pp. S38
Author(s):  
D. Larrey ◽  
M. Bourdi ◽  
J. Nataf ◽  
J. Bernuau ◽  
D. Pessayre ◽  
...  
Keyword(s):  
Human Liver ◽  
Liver Cytochrome ◽  
Cytochrome P 450

Metabolic activation of the tricyclic antidepressant amineptine by human liver cytochrome P-450

1987 ◽  
Vol 36 (14) ◽  
pp. 2421-2424 ◽  
Author(s):  
Jean Genève ◽  
Dominique Larrey ◽  
Gilles Amouyal ◽  
Jacques Belghiti ◽  
Dominique Pessayre
Keyword(s):  
Human Liver ◽  
Metabolic Activation ◽  
Tricyclic Antidepressant ◽  
Liver Cytochrome ◽  
Cytochrome P 450

Inactivation of human liver cytochrome P-450 by the drug methoxsalen and other psoralen derivatives

1987 ◽  
Vol 36 (6) ◽  
pp. 951-955 ◽  
Author(s):  
Marina Tinel ◽  
Jacques Belghiti ◽  
Veronique Descatoire ◽  
Gilles Amouyal ◽  
Philippe Letteron ◽  
...  
Keyword(s):  
Human Liver ◽  
Liver Cytochrome ◽  
Psoralen Derivatives ◽  
Cytochrome P 450

Nucleotide Sequence of a Human Liver Cytochrome P-450 Related to the Rat Male Specific Form1

1987 ◽  
Vol 102 (5) ◽  
pp. 1075-1082 ◽  
Author(s):  
Toshio YASUMORI ◽  
Sumie KAWANO ◽  
Kiyoshi NAGATA ◽  
Miki SHIMADA ◽  
Yasushi YAMAZOE ◽  
...  
Keyword(s):  
Nucleotide Sequence ◽  
Human Liver ◽  
Liver Cytochrome ◽  
Male Specific ◽  
Cytochrome P 450

scholarly journals Identification of the human liver cytochrome P-450 responsible for coumarin 7-hydroxylase activity

1990 ◽  
Vol 267 (2) ◽  
pp. 365-371 ◽  
Author(s):  
J S Miles ◽  
A W McLaren ◽  
L M Forrester ◽  
M J Glancey ◽  
M A Lang ◽  
...  
Keyword(s):  
Human Liver ◽  
Liver Microsomes ◽  
Microsomal Protein ◽  
Hydroxylase Activity ◽  
Liver Cytochrome ◽  
Partial Length ◽  
Coumarin 7 ◽  
Human Livers ◽  
Cell Expression ◽  
Cytochrome P 450

1. We have constructed a full-length human liver cytochrome P450IIA cDNA from a partial-length clone by oligonucleotide-directed mutagenesis, and subcloned it into the monkey kidney (COS-7) cell expression vector, pSVL. 2. The cDNA encodes a 49 kDa protein with coumarin 7-hydroxylase (COH) activity which cross-reacts with antisera to the mouse cytochrome P-450 isoenzyme responsible for COH activity and comigrates with a human liver microsomal protein. 3. Western blot analysis of a panel of human livers indicates that the level of the 49 kDa protein, detected using antisera to either the mouse COH P-450 or rat P450IIA1 protein, correlates very highly with COH activity. 4. Antisera to the rat P450IIA1 protein can inhibit COH activity in human liver microsomes. Taken together, these data indicate that a member of the P450IIA subfamily is responsible for most, if not all, of the COH activity in human liver.

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