R 56865 Differentiates between Contractile Agents with Respect to the Nifedipine-Sensitive Component in the Isolated Rat Aorta

Pharmacology ◽  
1989 ◽  
Vol 39 (1) ◽  
pp. 11-18 ◽  
Author(s):  
P. Koch ◽  
D. Wilhelm ◽  
B. Wilffert ◽  
T. Peters
Keyword(s):  
Rat Aorta ◽  
R 56865 ◽  
Isolated Rat

Effects of liposome-entrapped adenosine in the isolated rat aorta

1993 ◽  
Vol 250 (3) ◽  
pp. 489-492 ◽  
Author(s):  
Eugen Brailoiu ◽  
Dragomir N. Serban ◽  
Sebastian Slatineanu ◽  
Catalin M. Filipeanu ◽  
Bogdan C. Petrescu ◽  
...  
Keyword(s):  
Rat Aorta ◽  
Isolated Rat

Different effects of R 56865 and calcium entry blockers on K+- and noradrenaline-induced contractions and 45Ca uptake in rat aorta

1988 ◽  
Vol 158 (3) ◽  
pp. 183-190 ◽  
Author(s):  
Peter Koch ◽  
Doris Wilhelm ◽  
Detlef Wermelskirchen ◽  
Ute Nebel ◽  
Bob Wilffert ◽  
...  
Keyword(s):  
Rat Aorta ◽  
Calcium Entry ◽  
Calcium Entry Blockers ◽  
45Ca Uptake ◽  
R 56865

Human plasma-derived material with clonidine displacing substance (CDS)-like properties contracts the isolated rat aorta

1991 ◽  
Vol 11 (6) ◽  
pp. 343-351 ◽  
Author(s):  
Dennis Synetos ◽  
Vangelis G. Manolopoulos ◽  
Daphne Atlas ◽  
Eva Pipili-Synetos
Keyword(s):  
Human Plasma ◽  
Rat Aorta ◽  
Isolated Rat

Levobupivacaine-induced contraction of isolated rat aorta is calcium dependent

2011 ◽  
Vol 89 (7) ◽  
pp. 467-476 ◽  
Author(s):  
Ji Seok Baik ◽  
Ju-Tae Sohn ◽  
Seong-Ho Ok ◽  
Jae-Gak Kim ◽  
Hui-Jin Sung ◽  
...  
Keyword(s):  
Methylene Blue ◽  
Smooth Muscle ◽  
Calcium Influx ◽  
Rat Aorta ◽  
Isometric Tension ◽  
Guanosine Monophosphate ◽  
Response Curves ◽  
Calcium Dependent ◽  
Isolated Rat

Levobupivacaine is a long-acting local anesthetic that intrinsically produces vasoconstriction in isolated vessels. The goals of this study were to investigate the calcium-dependent mechanism underlying levobupivacaine-induced contraction of isolated rat aorta in vitro and to elucidate the pathway responsible for the endothelium-dependent attenuation of levobupivacaine-induced contraction. Isolated rat aortic rings were suspended to record isometric tension. Cumulative levobupivacaine concentration–response curves were generated in either the presence or absence of the antagonists verapamil, nifedipine, SKF-96365, 2-aminoethoxydiphenylborate, Gd3+, NW-nitro-l-arginine methyl ester (L-NAME), 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ), and methylene blue, either alone or in combination. Verapamil, nifedipine, SKF-96365, 2-aminoethoxydiphenylborate, low calcium concentrations, and calcium-free Krebs solution attenuated levobupivacaine-induced contraction. Gd3+ had no effect on levobupivacaine-induced contraction. Levobupivacaine increased intracellular calcium levels in vascular smooth muscle cells. L-NAME, ODQ, and methylene blue increased levobupivacaine-induced contraction in endothelium-intact aorta. SKF-96365 attenuated calcium-induced contraction in a previously calcium-free isotonic depolarizing solution containing 100 mmol/L KCl. Levobupivacaine-induced contraction of rat aortic smooth muscle is mediated primarily by calcium influx from the extracellular space mainly via voltage-operated calcium channels and, in part, by inositol 1,4,5-trisphosphate receptor-mediated release of calcium from the sarcoplasmic reticulum. The nitric oxide – cyclic guanosine monophosphate pathway is involved in the endothelium-dependent attenuation of levobupivacaine-induced contraction.

In vitro fructose exposure overactivates NADPH oxidase and causes oxidative stress in the isolated rat aorta

2015 ◽  
Vol 29 (8) ◽  
pp. 2030-2037 ◽  
Author(s):  
Camila C.P. Almenara ◽  
José G. Mill ◽  
Dalton V. Vassallo ◽  
Marcelo P. Baldo ◽  
Alessandra S. Padilha
Keyword(s):  
Oxidative Stress ◽  
Nadph Oxidase ◽  
Rat Aorta ◽  
Isolated Rat

Effects of Auranof in on Endothelium Dependent Contractions in Isolated Rat Aorta

1991 ◽  
pp. 83-87
Author(s):  
J. Fontaine ◽  
Z. Y. Fang ◽  
G. Berkenboom ◽  
J. P. Famaey
Keyword(s):  
Rat Aorta ◽  
Isolated Rat

Cinnamaldehyde Induces Endothelium-Dependent and -Independent Vasorelaxant Action on Isolated Rat Aorta

2006 ◽  
Vol 29 (12) ◽  
pp. 2415-2418 ◽  
Author(s):  
Ayano Yanaga ◽  
Hirozo Goto ◽  
Takako Nakagawa ◽  
Hiroaki Hikiami ◽  
Naotoshi Shibahara ◽  
...  
Keyword(s):  
Rat Aorta ◽  
Isolated Rat
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