Protective Effect of Nicorandil on Postischemic Function and Tissue Adenine Nucleotides following a Brief Period of Low-Flow Global Ischemia in the Isolated Perfused Rat Heart

Pharmacology ◽  
1989 ◽  
Vol 38 (4) ◽  
pp. 205-213 ◽  
Author(s):  
Galen M. Pieper ◽  
Garrett J. Gross
Keyword(s):  
Protective Effect ◽  
Rat Heart ◽  
Adenine Nucleotides ◽  
Global Ischemia ◽  
Low Flow ◽  
Perfused Rat Heart ◽  
Isolated Perfused Rat Heart

Adenine nucleotide synthesis from inosine during normoxia and after ischaemia in the isolated perfused rat heart

1985 ◽  
Vol 63 (9) ◽  
pp. 1159-1164 ◽  
Author(s):  
J. Aussedat ◽  
M. Verdys ◽  
A. Rossi
Keyword(s):  
Rat Heart ◽  
Adenine Nucleotide ◽  
Adenine Nucleotides ◽  
Low Flow ◽  
Nucleotide Synthesis ◽  
Perfused Rat Heart ◽  
Isolated Perfused Rat Heart ◽  
Nucleotide Content ◽  
Glycogen Stores

[14C]inosine in a range of concentrations of 20 μM to 1 mM was administered-to the isolated perfused rat heart for 30 min. The incorporation of the nucleoside into myocardial adenine nucleotides increased for extracellular concentrations of the precursor up to 50 μM, reaching a plateau at 60 nmol∙g−1∙30 min−1 with concentrations ranging between 50 and 200 μM. The supply of 500 μM and 1 mM of inosine induced a further increase in cardiac adenine nucleotide synthesis to about 200 nmol∙g−1∙30 min−1. When supplied during low flow ischaemia (0.5 mL∙min−1, 30 min.), 1 mM of inosine protected the heart against ATP degradation, while 100 μM of inosine was inefficacious. In the presence of 1 mM of inosine on reperfusion the adenine nucleotide content of the heart was similar to that observed in the absence of the nucleoside. The incorporation of [14C]inosine into adenine nucleotides was, in this last condition, below the value measured before ischaemia. Inosine administration was effective in protecting the heart against ischaemic breakdown of glycogen and favoured postischaemic restoration of glycogen stores.

scholarly journals Intermittent ischemia produces a cumulative depletion of mitochondrial adenine nucleotides in the isolated perfused rat heart.

1990 ◽  
Vol 66 (2) ◽  
pp. 302-310 ◽  
Author(s):  
G K Asimakis ◽  
G S Sandhu ◽  
V R Conti ◽  
L A Sordahl ◽  
J B Zwischenberger
Keyword(s):  
Rat Heart ◽  
Adenine Nucleotides ◽  
Perfused Rat Heart ◽  
Isolated Perfused Rat Heart

Protective effect of prazosin on the hydrogen peroxide-induced derangements in the isolated perfused rat heart

Life Sciences ◽  
1998 ◽  
Vol 62 (19) ◽  
pp. 1755-1766 ◽  
Author(s):  
Moe Akahira ◽  
Akiyoshi Hara ◽  
Hiroko Hashizume ◽  
Masao Nakamura ◽  
Yasushi Abiko
Keyword(s):  
Hydrogen Peroxide ◽  
Protective Effect ◽  
Rat Heart ◽  
Perfused Rat Heart ◽  
Isolated Perfused Rat Heart
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