Comparison of the Anti-Inflammatory Activity of Sodium Acexamate and Zinc Acexamate in Healing Skin Wounds in Rabbits

Pharmacology ◽  
1987 ◽  
Vol 34 (5) ◽  
pp. 296-300 ◽  
Author(s):  
Olivier Guillard ◽  
Philippe Masson ◽  
Alain Piriou ◽  
Jean-Christophe Brugier ◽  
Philippe Courtois
2017 ◽  
Vol 2017 ◽  
pp. 1-14 ◽  
Author(s):  
Mysrayn Y. F. A. Reis ◽  
Simone M. dos Santos ◽  
Danielle R. Silva ◽  
Márcia V. Silva ◽  
Maria Tereza S. Correia ◽  
...  

Babassu oil extraction is the main income source in nut breakers communities in northeast of Brazil. Among these communities, babassu oil is used for cooking but also medically to treat skin wounds and inflammation, and vulvovaginitis. This study aimed to evaluate the anti-inflammatory activity of babassu oil and develop a microemulsion system with babassu oil for topical delivery. Topical anti-inflammatory activity was evaluated in mice ear edema using PMA, arachidonic acid, ethyl phenylpropiolate, phenol, and capsaicin as phlogistic agents. A microemulsion system was successfully developed using a Span® 80/Kolliphor® EL ratio of 6 : 4 as the surfactant system (S), propylene glycol and water (3 : 1) as the aqueous phase (A), and babassu oil as the oil phase (O), and analyzed through conductivity, SAXS, DSC, TEM, and rheological assays. Babassu oil and lauric acid showed anti-inflammatory activity in mice ear edema, through inhibition of eicosanoid pathway and bioactive amines. The developed formulation (39% A, 12.2% O, and 48.8% S) was classified as a bicontinuous to o/w transition microemulsion that showed a Newtonian profile. The topical anti-inflammatory activity of microemulsified babassu oil was markedly increased. A new delivery system of babassu microemulsion droplet clusters was designed to enhance the therapeutic efficacy of vegetable oil.


Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
DA Uchil ◽  
SK Kamat ◽  
SS Menon ◽  
AM Scindia ◽  
GK Dang ◽  
...  

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
DM González Mosquera ◽  
A Kilonda ◽  
S Toppet ◽  
F Compernolle ◽  
W Dehaen ◽  
...  

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
J Ofeimun ◽  
B Ayinde ◽  
I Igbe ◽  
MI Choudhary ◽  
I Husain ◽  
...  

Planta Medica ◽  
2014 ◽  
Vol 80 (10) ◽  
Author(s):  
ME Acevedo-Quiroz ◽  
LP Álvarez Berber ◽  
S Marquina Bahena ◽  
A León Cabrera ◽  
A Cardoso Taketa ◽  
...  

Planta Medica ◽  
2014 ◽  
Vol 80 (16) ◽  
Author(s):  
P Monteiro ◽  
D Vendramini-Costa ◽  
AL Ruiz ◽  
MA Foglio ◽  
JE Carvalho

Planta Medica ◽  
2015 ◽  
Vol 81 (11) ◽  
Author(s):  
BM Lee ◽  
JS Lee ◽  
JA Kim ◽  
BS Min

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