Theophylline Kinetics: Dose Dependency and Single Sample Prediction of Clearance

Pharmacology ◽  
1985 ◽  
Vol 30 (3) ◽  
pp. 136-144 ◽  
Author(s):  
Kenneth Bachmann ◽  
Jules Schwartz ◽  
Robert Forney, Jr. ◽  
Luis Jauregui
Keyword(s):  
Single Sample ◽  
Dose Dependency ◽  
Theophylline Kinetics

A Simple Enzyme-Immunoassay (EIA) Test for Factor VIII-Related Antigen (VIIIAGN)

1979 ◽  
Vol 42 (03) ◽  
pp. 848-854 ◽  
Author(s):  
Paul M Ness ◽  
Herbert A Perkins
Keyword(s):  
Factor Viii ◽  
Enzyme Immunoassay ◽  
Hemophilia A ◽  
Single Sample ◽  
Healthy Controls ◽  
Von Willebrand's Disease ◽  
Factor Viii Related Antigen ◽  
Von Willebrand’S Disease ◽  
Increased Sensitivity

SummaryAn enzyme immunoassay (EIA) system has been developed to measure factor VIII- related antigen (VIIIAGN). This assay gives similar results to the commonly used Laurell electroimmunodiffusion (EID) assay for VIIIAGN as shown by comparison of both techniques with samples from healthy controls, patients with hemophilia A, and patients with von Willebrand’s disease. The assay also has a greater precision than the EID technique as demonstrated by multiple assays of aliquots of a single sample. The use of this EIA test for VIIIAGN is simple and employs inexpensive reagents and equipment. The use of expensive antisera is minimized. EIA for VIIIAGN has the advantage of increased sensitivity compared to Laurell EIA.

Levels of prolactin, FSH and LH pool vs single sample determination

2013 ◽  
Author(s):  
Sandra Belo ◽  
Selma Souto ◽  
Angela Magalhaes ◽  
Davide Carvalho ◽  
Joao Tiago Guimaraes
Keyword(s):  
Single Sample

Gravity Effect on the Formation of Periodic Precipitation Patterns

2000 ◽  
Vol 65 (9) ◽  
pp. 1438-1442 ◽  
Author(s):  
Vladislav Holba ◽  
Frederik Fusek
Keyword(s):  
Gravitational Field ◽  
Spatial Arrangement ◽  
Experimental Results ◽  
Single Sample ◽  
Gravity Effect ◽  
Periodic Precipitation ◽  
Precipitation Patterns ◽  
Liesegang Bands

The effect of gravity on the formation of Liesegang patterns of Ag2Cr2O7in gelatin and that of PbI2in agar was investigated. Spatial arrangement of Liesegang bands was measured in the parallel and antiparallel orientation to the gravitational field in a single sample with all other parameters kept fixed. The experimental results are discussed in terms of the prenucleation theory of periodic precipitation.

scholarly journals DSP Toxin Distribution across Organs in Mice after Acute Oral Administration

Marine Drugs ◽  
2021 ◽  
Vol 19 (1) ◽  
pp. 23
Author(s):  
M. Carmen Louzao ◽  
Paula Abal ◽  
Celia Costas ◽  
Toshiyuki Suzuki ◽  
Ryuichi Watanabe ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Small Intestine ◽  
Large Intestine ◽  
Safety Assessment ◽  
Liquid Chromatography Mass Spectrometry ◽  
Dose Dependency ◽  
Shellfish Poisoning ◽  
Diarrheic Shellfish Poisoning ◽  
Different Doses ◽  
Lipophilic Phycotoxins

Okadaic acid (OA) and its main structural analogs dinophysistoxin-1 (DTX1) and dinophysistoxin-2 (DTX2) are marine lipophilic phycotoxins distributed worldwide that can be accumulated by edible shellfish and can cause diarrheic shellfish poisoning (DSP). In order to study their toxicokinetics, mice were treated with different doses of OA, DTX1, or DTX2 and signs of toxicity were recorded up to 24 h. Toxin distribution in the main organs from the gastrointestinal tract was assessed by liquid chromatography-mass spectrometry (LC/MS/MS) analysis. Our results indicate a dose-dependency in gastrointestinal absorption of these toxins. Twenty-four hours post-administration, the highest concentration of toxin was detected in the stomach and, in descending order, in the large intestine, small intestine, and liver. There was also a different toxicokinetic pathway between OA, DTX1, and DTX2. When the same toxin doses are compared, more OA than DTX1 is detected in the small intestine. OA and DTX1 showed similar concentrations in the stomach, liver, and large intestine tissues, but the amount of DTX2 is much lower in all these organs, providing information on DSP toxicokinetics for human safety assessment.

Using μ2rheology to quantify rheological properties during repeated reversible phase transitions of soft matter

Lab on a Chip ◽  
2017 ◽  
Vol 17 (12) ◽  
pp. 2085-2094 ◽  
Author(s):  
Matthew D. Wehrman ◽  
Melissa J. Milstrey ◽  
Seth Lindberg ◽  
Kelly M. Schultz
Keyword(s):  
Phase Transitions ◽  
Rheological Properties ◽  
Soft Matter ◽  
Single Sample ◽  
Fluid Exchange ◽  
Reversible Phase ◽  
Surrounding Fluid

A novel microfluidic design enables repeated phase transitions in a single sample by surrounding fluid exchange and microrheological characterization.

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