Effect of Various Xenobiotics and Steroids on Aryl Hydrocarbon Hydroxylase Activity of Intestinal and Hepatic Microsomes from Male Rats

Pharmacology ◽  
1982 ◽  
Vol 25 (5) ◽  
pp. 237-249 ◽  
Author(s):  
Sidney J. Stohs ◽  
Christine L.J. Wu
Keyword(s):  
Male Rats ◽  
Aryl Hydrocarbon Hydroxylase ◽  
Hydroxylase Activity ◽  
Aryl Hydrocarbon ◽  
Hepatic Microsomes ◽  
Aryl Hydrocarbon Hydroxylase Activity

The effects of gonadectomy on the hepatic activities of aryl hydrocarbon hydroxylase, epoxide hydratase, and glutathione S-transferase in Wistar rats pretreated with oral methadone∙HCl

1979 ◽  
Vol 57 (3) ◽  
pp. 286-290 ◽  
Author(s):  
L. S. Gontovnick ◽  
L. Roelofs ◽  
G. D. Bellward
Keyword(s):  
Wistar Rats ◽  
Female Rats ◽  
Male Rats ◽  
Aryl Hydrocarbon Hydroxylase ◽  
Hydroxylase Activity ◽  
Glutathione S Transferase ◽  
Aryl Hydrocarbon ◽  
Epoxide Hydratase ◽  
Aryl Hydrocarbon Hydroxylase Activity ◽  
Hydratase Activity

Methadone∙HCl given in the drinking water for 4 weeks increased microsomal epoxide hydratase activity in the liver of adult male Wistar rats, with no change in aryl hydrocarbon hydroxylase activity. In contrast, in female rats it raised aryl hydrocarbon hydroxylase with no change in epoxide hydratase activity. Gonadectomy altered the effect of methadone on epoxide hydratase, but not on aryl hydrocarbon hydroxylase activity, in both sexes. In ovariectomized rats, but not in controls, methadone nearly doubled the epoxide hydratase activity, whereas in male rats castration decreased the inductive effect of methadone. Gonadectomy had a significant effect on the results of methadone treatment with respect to glutathione S-transferase activity in female rats. A sex difference was noted in the control levels of aryl hydrocarbon hydroxylase and glutathione S-transferase, but not of epoxide hydratase activity. The glutathione S-transferase and aryl hydrocarbon hydroxylase activities were decreased in castrated male rats, whereas epoxide hydratase activity was unaltered. It is concluded that sex hormones play an important role in the induction of epoxide hydratase and glutathione S-transferase by methadone, but not of aryl hydrocarbon hydroxylase, at this particular dosage regime.

Aryl Hydrocarbon Hydroxylase Activity “Of Mice and Humans”

1983 ◽  
pp. 179-197 ◽  
Author(s):  
R. E. Kouri ◽  
R. A. Lubet ◽  
C. E. McKinney ◽  
G. M. Connolly ◽  
D. W. Nebert ◽  
...  
Keyword(s):  
Aryl Hydrocarbon Hydroxylase ◽  
Hydroxylase Activity ◽  
Aryl Hydrocarbon ◽  
Aryl Hydrocarbon Hydroxylase Activity
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