Tricyclic Antidepressant Determination in Human Plasma by Gas-Liquid Chromatography Using Nitrogen-Phosphorous Detection: Application to Single-Dose Pharmacokinetic Studies

Pharmacology ◽  
1981 ◽  
Vol 23 (2) ◽  
pp. 57-63 ◽  
Author(s):  
Darrell R. Abernethy ◽  
David J. Greenblatt ◽  
Richard I. Shader
Keyword(s):  
Liquid Chromatography ◽  
Single Dose ◽  
Human Plasma ◽  
Tricyclic Antidepressant ◽  
Pharmacokinetic Studies ◽  
Gas Liquid Chromatography

Identification and metabolic implication of 1-deoxyglucose (1,5-anhydroglucitol) in human plasma.

1982 ◽  
Vol 28 (6) ◽  
pp. 1283-1286 ◽  
Author(s):  
S Yoshioka ◽  
S Saitoh ◽  
T Fujisawa ◽  
A Fujimori ◽  
O Takatani ◽  
...  
Keyword(s):  
Liquid Chromatography ◽  
Human Plasma ◽  
Capillary Column ◽  
Physiological Role ◽  
Glass Capillary Column ◽  
Gas Liquid Chromatography ◽  
Liquid Chromatography Mass Spectrometry ◽  
Glass Capillary ◽  
Liquid Chromatograph

Abstract 1-Deoxyglucose (1,5-anhydroglucitol), a metabolite related to diabetes mellitus, was identified in human plasma by gas-liquid chromatography and by gas-liquid chromatography/mass spectrometry. Plasma polyols were accurately determined with a gas-liquid chromatograph equipped with an all-glass capillary column. The plasma content of 1-deoxyglucose in healthy persons varies with age. Although the precise physiological role of 1-deoxyglucose remains obscure, the method described here for determining the minor polyol components of plasma, as well as the findings of 1-deoxyglucose in the plasma of healthy subjects, may be useful for investigating the metabolic roles of 1-deoxyglucose.

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