Effect of Benzyloxyguanidine (13958 RP) on the Increase of Blood Glucose and Plasma Free Fatty Acids Induced by Various Drugs in Rats

Pharmacology ◽  
1967 ◽  
Vol 17 (1) ◽  
pp. 25-32
Author(s):  
A. Jori ◽  
A. Bianchetti
Keyword(s):  
Fatty Acids ◽  
Blood Glucose ◽  
Free Fatty Acids ◽  
Plasma Free Fatty Acids

The Positive Correlation between Insulin Resistance and Duration of Hospitalization in Untreated Schizophrenia

1971 ◽  
Vol 118 (545) ◽  
pp. 429-436 ◽  
Author(s):  
Werner H. Schimmelbusch ◽  
Peter S. Mueller ◽  
Jack Sheps
Keyword(s):  
Insulin Resistance ◽  
Fatty Acids ◽  
Blood Glucose ◽  
Free Fatty Acids ◽  
Chronic Schizophrenia ◽  
Intravenous Glucose ◽  
Plasma Free Fatty Acids ◽  
Chronic Schizophrenic ◽  
Duration Of Hospitalization ◽  
Schizophrenic Patients

Various abnormalities have been demonstrated in schizophrenic patients in response to injected insulin. Thomaset al.(22), Harris (8), Freemanet al.(7), Mayer-Gross (10), and Bracelandet al.(4) have shown a delayed or decreased response of blood glucose to insulin in schizophrenic patients. Meduna and McCulloch (11) observed that those schizophrenic patients who suffered from confusion and clouding of the sensorium particularly displayed a delayed or decreased response to injected insulin as well as a urinary hyperglycaemic factor and decreased tolerance to oral and intravenous glucose. Subsequent studies by Mueller (12, 13) demonstrated a rise or lack of fall in the plasma free fatty acids (FFA) following the administration of insulin intramuscularly or intravenously in chronic schizophrenic patients. Van Sickleet al.(23) confirmed these findings of insulin resistance in chronic schizophrenia and noted that this low FFA response was neither related to an abnormal release of, nor response to, epinephrine.

Plasma free fatty acids in exercise

1964 ◽  
Vol 19 (3) ◽  
pp. 489-492 ◽  
Author(s):  
K. Rodahl ◽  
H. I. Miller ◽  
B. Issekutz
Keyword(s):  
Fatty Acids ◽  
Lipid Metabolism ◽  
Blood Glucose ◽  
Free Fatty Acids ◽  
Blood Sugar ◽  
Blood Lactate ◽  
Marked Change ◽  
Apparent Discrepancy ◽  
Plasma Free Fatty Acids ◽  
Plasma Ffa

The effects of exercise of different intensity and duration on plasma free fatty acids (FFA), blood glucose, and lactate were investigated in eight healthy young men. In heavy 10-min work the blood lactate rose rapidly and the FFA decreased. Blood sugar showed no marked change. Intermittent work caused a slight increase in blood lactate and no change in blood glucose. The FFA remained essentially unchanged but increased in three out of four subjects during recovery. In moderate 1-hr work the FFA remained essentially unchanged, but increased markedly during recovery when blood lactate had returned to resting levels. In prolonged exhausting work in fasting subjects, the blood lactate remained almost unchanged, while the FFA rose steadily and the blood sugar dropped. In nonfasting subjects the FFA also rose, but the ingestion of lunch caused, in all cases, a striking drop in the FFA, associated with a rise in blood sugar. Combined hormonal effects (insulin and norepinephrine) brought into play during exercise of different intensity and duration may well explain the apparent discrepancy in the results of different investigators concerning the effect of exercise on plasma FFA. work and FFA; FFA at different workloads; lipid metabolism in work Submitted on November 6, 1963

A fat-mobilizing substance in chicken urine

1969 ◽  
Vol 47 (5) ◽  
pp. 435-443 ◽  
Author(s):  
I. Nir ◽  
Mildred K. Dimick ◽  
S. Lepkovsky
Keyword(s):  
Fatty Acids ◽  
Blood Glucose ◽  
Food Intake ◽  
Free Fatty Acids ◽  
Plasma Cholesterol ◽  
Lipid Phosphorus ◽  
Male And Female ◽  
Plasma Free Fatty Acids ◽  
Plasma Triglycerides ◽  
Plasma Ffa

A fat-mobilizing substance (FMS) was extracted from the urine of fasting male and female chickens. Injection into chickens caused transient decreases in food intake and transient increases in plasma free fatty acids (FFA). These effects were accompanied by persisting decreases in plasma triglycerides. FMS also caused persistent decreases in plasma cholesterol and lipid phosphorus. Slight elevations of blood glucose occurred, but they were not statistically significant. FMS obtained from the urine of fed chickens by the same technique as that used with fasting chickens varied in its activity; at times it was similar to the FMS obtained from fasting chickens and at other times had little effect on plasma FFA and food intake. FMS elicited smaller increases in plasma FFA in laying hens than it did in males, possibly as a result of higher pre-injection levels in the hens. In contrast to findings in mammals, FMS was obtained from the urine of hypophysectomized chickens. Differences in response to FMS among mice, rats, and chickens are discussed.

scholarly journals Metabolic changes in rats during developing thiamin deficiency.(Short Communications)

1975 ◽  
Vol 146 (3) ◽  
pp. 739-740 ◽  
Author(s):  
C C Liang
Keyword(s):  
Fatty Acids ◽  
Blood Glucose ◽  
Metabolic Rate ◽  
Free Fatty Acids ◽  
Rectal Temperature ◽  
Thiamin Deficiency ◽  
Plasma Free Fatty Acids ◽  
Fat Reserves ◽  
Glucose Plasma ◽  
Normal Controls

Determinations of rectal temperature, blood glucose, plasma free fatty acids, liver acetyl-CoA and carcass fat of thiamin-deficient rats indicated that during the ensuing anorexia they metabolized their fat reserves more rapidly than did pair-fed normal controls. Their lower metabolic rate indicates that the reserves mobilized are utilized inefficiently.

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