Neurochemical and Neuropharmacological Investigations with Four Ergot Derivatives: Bromocriptine, Dihydroergotoxine, CF 25-397 and CM 29-712

J.M. Vigouret; H.R. B&uuml;rki; A.L. Jaton; P.E. Z&uuml;ger; D.M. Loew

doi:10.1159/000136817

Neurochemical and Neuropharmacological Investigations with Four Ergot Derivatives: Bromocriptine, Dihydroergotoxine, CF 25-397 and CM 29-712

Pharmacology ◽

10.1159/000136817 ◽

1978 ◽

Vol 16 (1) ◽

pp. 156-173 ◽

Cited By ~ 53

Author(s):

J.M. Vigouret ◽

H.R. Bürki ◽

A.L. Jaton ◽

P.E. Züger ◽

D.M. Loew

Keyword(s):

Ergot Derivatives

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Dimerization of ergot derivatives

Tetrahedron Letters ◽

10.1016/s0040-4039(01)86903-3 ◽

1973 ◽

Vol 14 (35) ◽

pp. 3315-3316 ◽

Cited By ~ 6

Author(s):

N.J. Bach ◽

E.C. Kornfeld

Keyword(s):

Ergot Derivatives

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A COMPARISON OF THE EFFECTS OF FOUR ERGOT DERIVATIVES ON PROLACTIN SECRETION BY DISPERSED RAT PITUITARY CELLS

Journal of Endocrinology ◽

10.1677/joe.0.0870095 ◽

1980 ◽

Vol 87 (1) ◽

pp. 95-103 ◽

Cited By ~ 11

Author(s):

G. DELITALA ◽

T. YEO ◽

ASHLEY GROSSMAN ◽

N. R. HATHWAY ◽

G. M. BESSER

Keyword(s):

Anterior Pituitary ◽

Ergot Alkaloids ◽

Prolactin Secretion ◽

Pituitary Cells ◽

Inhibitory Effects ◽

Prolactin Release ◽

Ergot Derivatives ◽

Rat Pituitary ◽

Rat Pituitary Cells

The inhibitory effects of dopamine and various ergot alkaloids on prolactin secretion were studied using continuously perfused columns of dispersed rat anterior pituitary cells. Bromocriptine (5 nmol/l) and lisuride hydrogen maleate (5 nmol/l) both inhibited prolactin secretion, the effects persisting for more than 3 h after the end of the administration of the drugs. A similar although less long-lasting effect was observed with lergotrile (50 nmol/l) and the new ergoline derivative, pergolide (5 nmol/l). These effects contrasted with the rapid disappearance of the action of dopamine. The potency estimates of the ergots relative to that of dopamine were: lergotrile, 2·3; bromocriptine, 13; lisuride, 15; pergolide, 23. The dopamine-receptor blocking drugs, metoclopramide and haloperidol, antagonized the prolactin release-inhibiting activity of the compounds; bromocriptine and lisuride showed the highest resistance to this dopaminergic blockade. The results suggested that the direct effect of the ergot derivatives on dispersed pituitary cells was mediated through dopamine receptors and emphasized the long-lasting action of bromocriptine and lisuride in vitro.

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