Influence of the Oral Contraceptive, Mestranol, on Drug-Metabolizing Enzymes of Female Rats in Thiamin-Supplemented and Deficiency States

Pharmacology ◽  
1976 ◽  
Vol 14 (2) ◽  
pp. 104-114 ◽  
Author(s):  
Adelbert E. Wade ◽  
Jenet lee Evans ◽  
Anna Seitz
Keyword(s):  
Oral Contraceptive ◽  
Female Rats ◽  
Drug Metabolizing Enzymes ◽  
Metabolizing Enzymes

Effects of pregnenolone-16 α - carbonitrile on drug metabolizing enzymes in hypophysectomized female rats

Life Sciences ◽  
1987 ◽  
Vol 41 (9) ◽  
pp. 1141-1148 ◽  
Author(s):  
Marvin T. Williams ◽  
Denise Leonard ◽  
Lizette Simonet
Keyword(s):  
Female Rats ◽  
Drug Metabolizing Enzymes ◽  
Metabolizing Enzymes

The effect of medroxyprogesterone acetate on the hepatic drug-metabolizing enzymes in normal and protein-deficient female rats

1985 ◽  
Vol 34 (1) ◽  
pp. 11-16 ◽  
Author(s):  
J.P. Nagpal ◽  
K.L. Khanduja ◽  
R.R. Sharma ◽  
S. Majumdar ◽  
R. Singh ◽  
...  
Keyword(s):  
Medroxyprogesterone Acetate ◽  
Female Rats ◽  
Drug Metabolizing Enzymes ◽  
Metabolizing Enzymes ◽  
Hepatic Drug

scholarly journals Effect of the leafy vegetable Solanum nigrum on the activities of some liver drug-metabolizing enzymes after aflatoxin B1 treatment in female rats

1991 ◽  
Vol 65 (1) ◽  
pp. 81-91 ◽  
Author(s):  
Paul F. Moundipa ◽  
Felicite Mbiapo Domngang
Keyword(s):  
Solanum Nigrum ◽  
Female Rats ◽  
Drug Metabolizing Enzymes ◽  
Uridine Diphosphate ◽  
Glutathione S Transferase ◽  
General Increase ◽  
Metabolizing Enzymes ◽  
Hepatic Microsomes ◽  
Demethylase Activity ◽  
Aflatoxin B

Wistar albino female rats were maintained for 10 d on diets containing various levels of the vegetable Solanum nigrum. Simultaneously, they received daily intraperitoneal injections of aflatoxin B1 (AFB1) (either 0.2 or 0.4 mg/kg body-weight) diluted in propylene glycol. At the end of the experiment, all animals were killed and their serum and hepatic microsomes were prepared for assay of enzymes. Results showed that aminopyrine N-demethylase activity increased 2.5-fold with 200 (S200) and 600 (S600) g S. nigrum/kg diets. Activity of uridine diphosphate glucuronyltransferase (UDPGT) (EC 2.4.17) also increased twofold. Similar results were obtained with glutathione S-transferase (EC 2.5.1.18) activity which increased by 60% with diet S600. After AFB1 treatment, a general increase in the activities of the above enzymes was found, except for UDPGT in the group fed on diet S600. When rats were fed on the diet without S. nigrum, AFB1 induced an increase in alkaline phosphatase (ALP) (EC 3. 1. 3. 1), aspartate aminotransferase (AST) (EC 2. 6. 1. 1) and γ-glutamyltransferase (γ-GT) (EC 2. 3. 2. 2) levels in the serum. AFB1 also induced increases in serum ALP and γ-GT levels when rats were fed on diet S600

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