Inhibitory Effects of Eicosapentaenoic Acid on Chronic Cerebral Vasospasm after Subarachnoid Hemorrhage: Possible Involvement of a Sphingosylphosphorylcholine-Rho-Kinase Pathway

2008 ◽  
Vol 26 (1) ◽  
pp. 30-37 ◽  
Author(s):  
Satoshi Shirao ◽  
Hirosuke Fujisawa ◽  
Akira Kudo ◽  
Tetsu Kurokawa ◽  
Hiroshi Yoneda ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Eicosapentaenoic Acid ◽  
Cerebral Vasospasm ◽  
Rho Kinase ◽  
Inhibitory Effects ◽  
Chronic Cerebral Vasospasm ◽  
Kinase Pathway

scholarly journals Alteration of Basilar Artery Rho-Kinase and Soluble Guanylyl Cyclase Protein Expression in a Rat Model of Cerebral Vasospasm following Subarachnoid Hemorrhage

2014 ◽  
Vol 2014 ◽  
pp. 1-8
Author(s):  
Chih-Jen Wang ◽  
Pei-Yu Lee ◽  
Bin-Nan Wu ◽  
Shu-Chuan Wu ◽  
Joon-Khim Loh ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Protein Kinase ◽  
Protein Expression ◽  
Cerebral Vasospasm ◽  
Basilar Artery ◽  
Guanylyl Cyclase ◽  
Autologous Blood ◽  
Rho Kinase ◽  
Soluble Guanylyl Cyclase ◽  
Western Blots

Background and Purpose. The vasoconstrictor endothelin-1 (ET-1) has been implicated in the pathogenesis of cerebral vasospasm following subarachnoid hemorrhage (SAH). Previous results showed that CGS 26303, an endothelin converting enzyme (ECE) inhibitor, effectively prevented and reversed arterial narrowing in animal models of SAH. In the present study, we assessed the effect of CGS 26303 on neurological deficits in SAH rats. The involvement of vasoactive pathways downstream of ET-1 signaling in SAH was also investigated.Methods. Sprague-Dawley rats were divided into five groups (n=6/group): (1) normal control, (2) SAH, (3) SAH+vehicle, (4) SAH+CGS 26303 (prevention), and (5) SAH+CGS 26303 (reversal). SAH was induced by injecting autologous blood into cisterna magna. CGS 26303 (10 mg/kg) was injected intravenously at 1 and 24 hr after the initiation of SAH in the prevention and reversal protocols, respectively. Behavioral changes were assessed at 48 hr after SAH. Protein expression was analyzed by Western blots.Results. Deficits in motor function were obvious in the SAH rats, and CGS 26303 significantly improved the rate of paraplegia. Expressions of rho-kinase-II and membrane-bound protein kinase C-δand rhoA were significantly increased, while those of soluble guanylyl cyclaseα1andβ1as well as protein kinase G were significantly decreased in the basilar artery of SAH rats. Treatment with CGS 26303 nearly normalized these effects.Conclusions. These results demonstrate that the rhoA/rho-kinase and sGC/cGMP/PKG pathways play pivotal roles in cerebral vasospasm after SAH. It also shows that ECE inhibition is an effective strategy for the treatment of this disease.

scholarly journals Effectiveness of high dose eicosapentaenoic acid for prevention of cerebral vasospasm secondary to subarachnoid hemorrhage

Nosotchu ◽  
2010 ◽  
Vol 32 (2) ◽  
pp. 146-150
Author(s):  
Hirokazu Nakatogawa ◽  
Tomohiro Yamasaki ◽  
Nakao Ota ◽  
Tadashi Doden ◽  
Tomohiro Yamazoe ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Eicosapentaenoic Acid ◽  
Cerebral Vasospasm ◽  
High Dose

Effect of recombinant streptokinase on the development of chronic cerebral vasospasm after subarachnoid hemorrhage in a swine model

2011 ◽  
Vol 153 (6) ◽  
pp. 1333-1338 ◽  
Author(s):  
Hongzhi Xu ◽  
Xiancheng Chen ◽  
Zhiyong Qin ◽  
Yuxiang Gu ◽  
Ping Zhou
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Cerebral Vasospasm ◽  
Swine Model ◽  
Chronic Cerebral Vasospasm
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