Chemical Contraction and Relaxation of Collagen Fibres in Rats with Experimental Lathyrism

Pharmacology ◽  
1963 ◽  
Vol 9 (1) ◽  
pp. 41-45
Author(s):  
Zdena Trnavská ◽  
Karel Trnavský
Keyword(s):  
Collagen Fibres ◽  
Contraction And Relaxation ◽  
Experimental Lathyrism

Contraction and Relaxation of Collagen Fibres

Nature ◽  
1954 ◽  
Vol 174 (4434) ◽  
pp. 788-789 ◽  
Author(s):  
I. BANGA ◽  
J. BALÓ ◽  
D. SZABÓ
Keyword(s):  
Collagen Fibres ◽  
Contraction And Relaxation

Effect of Decalcification on Chemical Contraction and Relaxation of Collagen Fibres

Gerontology ◽  
1967 ◽  
Vol 13 (4) ◽  
pp. 246-252 ◽  
Author(s):  
Z. Hrůza ◽  
V. Hlavackova
Keyword(s):  
Collagen Fibres ◽  
Contraction And Relaxation

scholarly journals Effect of valproic acid on functional bleb morphology in a rabbit model of minimally invasive surgery

2021 ◽  
pp. bjophthalmol-2020-318691
Author(s):  
Zhu Li Yap ◽  
Li-Fong Seet ◽  
Stephanie WL Chu ◽  
Li Zhen Toh ◽  
Farah Ilyana Ibrahim ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Cell Growth ◽  
Minimally Invasive ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Rabbit Model ◽  
Terminal Deoxynucleotidyl Transferase ◽  
Label Free ◽  
Collagen Fibres

AbstractPurposeTo determine the effect of valproic acid (VPA) on bleb morphology and scar characteristics in a rabbit model of minimally invasive glaucoma surgery (MIGS).MethodsNine New Zealand white rabbits were subjected to MIGS with intraoperative implantation of the PreserFlo MicroShunt. Rabbits were then administered with subconjunctival injections of phosphate buffered saline (PBS) (n=4) or with VPA (n=5). Bleb morphology was examined by slit-lamp biomicroscopy and in vivo confocal microscopy. Postoperative day 28 tissues were examined by immunohistochemical evaluation and label-free multiphoton microscopy to visualise the collagen matrix, by terminal deoxynucleotidyl transferase dUTP nick-end labelling assay and immunofluorescent labelling for Ki67 expression to detect apoptosis and cell growth, and by real-time quantitative PCR to measure Col1a1, Fn, and Smad6 transcript expression.ResultsVPA-treated blebs were detectable on day 28, while the PBS-treated blebs were not detectable by day 14. VPA-treated blebs were diffuse, extended posteriorly with near normal conjunctival vascularity and featured a combination of reticular/blurred stromal pattern with evidence of relatively large stromal cysts. Instead of the deposition of thick, disorganised collagen fibres characteristic of the PBS bleb, the VPA bleb contained conspicuously thinner collagen fibres which were associated with similarly thinner fibronectin fibres. In corroboration, Col1a1 and Fn mRNA expression was reduced in the VPA blebs, while increased Smad6 expression implicated the disruption of the transforming growth factor beta pathway. Apoptosis and cell growth profiles appeared similar with both treatments.ConclusionsThe results support the application of VPA to enhance bleb morphology associated with good bleb function in MIGS with no apparent cytotoxicity.

Biosynthesis of Collagen Fibres

1970 ◽  
Vol 38 (2) ◽  
pp. 7P-7P ◽  
Author(s):  
D. S. Jackson
Keyword(s):  
Collagen Fibres

scholarly journals Effects of alloimmune injury on contraction and relaxation in cultured myocytes and intact cardiac allografts

1994 ◽  
Vol 24 (7) ◽  
pp. 1769-1778 ◽  
Author(s):  
R.Douglas Ensley ◽  
Martha Ives ◽  
Liping Zhao ◽  
Mischelle McMillan ◽  
Jane Shelby ◽  
...  
Keyword(s):  
Cardiac Allografts ◽  
Contraction And Relaxation

scholarly journals EXPERIMENTAL LATHYRISM IN THE CHICK EMBRYO

1963 ◽  
Vol 117 (6) ◽  
pp. 1009-1018 ◽  
Author(s):  
Serge D. Orloff ◽  
Jerome Gross
Keyword(s):  
Chick Embryo ◽  
Incubation Temperature ◽  
Electrophoretic Analysis ◽  
Ion Exchange Chromatography ◽  
Exchange Chromatography ◽  
Metabolic Process ◽  
Radioactive Material ◽  
Bone Collagen ◽  
Cyanoacetic Acid ◽  
Experimental Lathyrism

1. C14-labeled ß-aminopropionitrile distributed throughout the egg contents within 10 minutes postinjection. By ion exchange chromatography and electrophoretic analysis three major components of the extractable dialyzable radioactive material could be demonstrated, representing at least 80 per cent of the total. The acidic and basic components were identified as ß-aminopropionitrile and cyanoacetic acid, while the fraction isoelectric at pH 5.3, consisting of two components, remained unidentified. 2. Less than 1 molecule of ßAPN per 100 molecules of protein was present in the highly purified extractable lathyritic bone collagen indicating that binding of the lathyrogen is not a factor in collagen extractability. 3. The proximity of ßAPN to collagen in bone is not essential to its extractability. 4. The effect of incubation temperature of the embryo on collagen extractability suggests the involvement of a metabolic process in this phenomenon.

Histamine-Induced Contraction and Relaxation of Placental Chorionic Plate Arteries

Placenta ◽  
2007 ◽  
Vol 28 (11-12) ◽  
pp. 1158-1164 ◽  
Author(s):  
T.A. Mills ◽  
M.J. Taggart ◽  
S.L. Greenwood ◽  
P.N. Baker ◽  
M. Wareing
Keyword(s):  
Chorionic Plate ◽  
Contraction And Relaxation
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