Assignment1 of the gene for a developmentally regulated GTP-binding protein (DRG2) to human chromosome bands 17p13→p12 by in situ hybridization

1997 ◽  
Vol 79 (3-4) ◽  
pp. 274-275 ◽  
Author(s):  
T. schenker ◽  
B. Trueb
Keyword(s):  
In Situ Hybridization ◽  
Human Chromosome ◽  
Binding Protein ◽  
Gtp Binding Protein ◽  
Developmentally Regulated ◽  
Gtp Binding ◽  
Chromosome Bands

Assignment1 of OSTF1 to human chromosome bands 12q24.1→q24.2 by in situ hybridization

2000 ◽  
Vol 88 (1-2) ◽  
pp. 87-88 ◽  
Author(s):  
R. Schaub ◽  
B. Dupont ◽  
G.D. Roodman ◽  
R.J. Leach ◽  
S.V. Reddy
Keyword(s):  
In Situ Hybridization ◽  
Human Chromosome ◽  
Chromosome Bands

scholarly journals Developmentally Regulated GTP binding protein 1 (DRG1) controls microtubule dynamics

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Anna Katharina Schellhaus ◽  
Daniel Moreno-Andrés ◽  
Mayank Chugh ◽  
Hideki Yokoyama ◽  
Athina Moschopoulou ◽  
...  
Keyword(s):  
Binding Protein ◽  
Microtubule Dynamics ◽  
Gtp Binding Protein ◽  
Developmentally Regulated ◽  
Gtp Binding

scholarly journals Developmentally regulated GTP-binding protein 1 modulates ciliogenesis via an interaction with Dishevelled

2019 ◽  
Vol 218 (8) ◽  
pp. 2659-2676 ◽  
Author(s):  
Moonsup Lee ◽  
Yoo-Seok Hwang ◽  
Jaeho Yoon ◽  
Jian Sun ◽  
Adam Harned ◽  
...  
Keyword(s):  
Actin Polymerization ◽  
Binding Protein ◽  
Basal Bodies ◽  
Apical Surface ◽  
Gtp Binding Protein ◽  
Developmentally Regulated ◽  
Rhoa Activity ◽  
Gtp Binding ◽  
Xenopus Laevis Embryo ◽  
Multiciliated Cells

Cilia are critical for proper embryonic development and maintaining homeostasis. Although extensively studied, there are still significant gaps regarding the proteins involved in regulating ciliogenesis. Using the Xenopus laevis embryo, we show that Dishevelled (Dvl), a key Wnt signaling scaffold that is critical to proper ciliogenesis, interacts with Drg1 (developmentally regulated GTP-binding protein 1). The loss of Drg1 or disruption of the interaction with Dvl reduces the length and number of cilia and displays defects in basal body migration and docking to the apical surface of multiciliated cells (MCCs). Moreover, Drg1 morphants display abnormal rotational polarity of basal bodies and a decrease in apical actin and RhoA activity that can be attributed to disruption of the protein complex between Dvl and Daam1, as well as between Daam1 and RhoA. These results support the concept that the Drg1–Dvl interaction regulates apical actin polymerization and stability in MCCs. Thus, Drg1 is a newly identified partner of Dvl in regulating ciliogenesis.

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