Response to Definitive Chemoradiotherapy and Survival in Patients with an Oesophageal Adenocarcinoma versus Squamous Cell Carcinoma: A Matched-Pair Analysis

Oncology ◽  
2007 ◽  
Vol 73 (5-6) ◽  
pp. 328-334 ◽  
Author(s):  
David Tougeron ◽  
Frédéric Di Fiore ◽  
Hadji Hamidou ◽  
Olivier Rigal ◽  
Bernard Paillot ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Oesophageal Adenocarcinoma ◽  
Matched Pair ◽  
Definitive Chemoradiotherapy ◽  
Matched Pair Analysis ◽  
Pair Analysis

scholarly journals Upfront Surgery vs. Primary Chemoradiation in an Unselected, Bicentric Patient Cohort with Oropharyngeal Squamous Cell Carcinoma—A Matched-Pair Analysis

Cancers ◽  
2021 ◽  
Vol 13 (21) ◽  
pp. 5265
Author(s):  
Philipp H. Zimmermann ◽  
Marijn Stuut ◽  
Nora Wuerdemann ◽  
Kathrin Möllenhoff ◽  
Malte Suchan ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Oropharyngeal Squamous Cell Carcinoma ◽  
Matched Pair ◽  
Factors Affecting ◽  
Matched Pair Analysis ◽  
New Therapeutic Approaches ◽  
Hpv Status ◽  
Pair Analysis

The two pillars of therapy for oropharyngeal squamous cell carcinoma (OPSCC) are upfront surgery and primary chemoradiotherapy. Substantial regional preferences exist with regard to the selection of treatment. Despite new therapeutic approaches, patient survival remains poor, with an approximate overall survival (OS) rate of 50% at five years. This study was conducted to investigate a potential survival benefit depending on the treatment modality in OPSCC patients. We retrospectively collected data of 853 patients with histologically confirmed OPSCC from the Giessen and Maastricht cancer databases. To identify risk factors affecting survival, a Cox-proportional hazard model was applied to 442 patients with complete data sets. Based on this cohort a matched-pair analysis with 158 patients was performed to compare OS rates of patients treated either with upfront surgery or primary chemoradiation. For the collective cohort, patients treated with upfront surgery had significantly improved OS rates compared to patients treated with primary chemoradiation. In the matched-pair analysis adjusted for patients’ T-, N- and HPV-status as well as risk profile, we observed that both treatment approaches offered equivalent OS rates. Our study emphasizes that treatment recommendations should be made whenever possible on the basis of side-effect profiles caused by the therapeutic approach used. To draw further conclusions, results of the ongoing “best of” (NCT2984410) study are eagerly awaited, investigating the functional outcome after treatment of OPSCC patients.

Squamous cell carcinoma of the oral tongue in young patients: a matched-pair analysis

2007 ◽  
Vol 127 (11) ◽  
pp. 1214-1217 ◽  
Author(s):  
Ching-Chih Lee ◽  
Hsu-Chueh Ho ◽  
Huang-Li Chen ◽  
Shih-Hsuan Hsiao ◽  
Juen-Haur Hwang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Young Patients ◽  
Matched Pair ◽  
Oral Tongue ◽  
Matched Pair Analysis ◽  
Pair Analysis

Matched-Pair Analysis of Survival of Never Smokers and Ever Smokers With Squamous Cell Carcinoma of the Head and Neck

2004 ◽  
Vol 22 (19) ◽  
pp. 3981-3988 ◽  
Author(s):  
Kristen B. Pytynia ◽  
Jonathan R. Grant ◽  
Carol J. Etzel ◽  
Dianna B. Roberts ◽  
Qingyi Wei ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Alcohol Use ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Matched Pair ◽  
Matched Pair Analysis ◽  
History Of ◽  
Never Smokers ◽  
Pair Analysis

Purpose To compare survival rates between patients with squamous cell carcinoma of the head and neck (SCCHN) without a history of smoking (never smokers) and those with a current or previous history of smoking (ever smokers). Patients and Methods Fifty never smokers with newly diagnosed SCCHN were matched to 50 ever smokers according to sex, age, tumor site, overall stage, nodal stage, and treatment. Survival analysis was performed using Kaplan-Meier estimates. Matched-pair survival was compared using the Cox proportional hazards model. Results The never smokers had a greater overall survival (P = .020), disease-specific survival (P = .022), and recurrence-free survival (P = .016). Furthermore, matched-pair analysis demonstrated smoking was associated with a significant increase in risk of overall death (relative risk [RR] = 3.50; 95% CI, 1.14 to 10.77; P = .029), risk of death owing to disease (RR = 3.98; 95% CI, 1.11 to 14.33; P = .034), and risk of disease recurrence (RR = 3.29; 95% CI, 1.18 to 9.14; P = .023). Smoking was associated with three-fold increases in risk for overall death, death owing to disease, and recurrence after adjustment for cancer-associated symptom severity and alcohol use, but the 95% CI for these adjusted risk estimates each included the null. Conclusion Survival differed significantly between never smokers and ever smokers with SCCHN. These results are not substantively explained by differences in cancer-associated symptoms or alcohol use, but the CIs are wide and some imprecision remains. Regardless, possible fundamental differences in SCCHN between ever smokers and never smokers may exist, and further molecular characterization of these tumors is needed to determine whether biologic differences needing targeted therapies exist.

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