Genetic mapping of GLCLC, the human gene encoding the catalytic subunit of γ-glutamyl-cysteine synthetase, to chromosome band 6p12 and characterization of a polymorphic trinucleotide repeat within its 5’ untranslated region

1996 ◽  
Vol 75 (1) ◽  
pp. 14-16 ◽  
Author(s):  
A.C. Walsh ◽  
W. Li ◽  
D.R. Rosen ◽  
D.A. Lawrence
Keyword(s):  
Genetic Mapping ◽  
Untranslated Region ◽  
Trinucleotide Repeat ◽  
Human Gene ◽  
Catalytic Subunit ◽  
Chromosome Band ◽  
Gene Encoding ◽  
Gamma Glutamyl ◽  
Cysteine Synthetase

scholarly journals Identification and Characterization of Novel Mutations in the Human Gene Encoding the Catalytic Subunit Calpha of Protein Kinase A (PKA)

PLoS ONE ◽  
2012 ◽  
Vol 7 (4) ◽  
pp. e34838 ◽  
Author(s):  
Kristoffer Søberg ◽  
Anja C. V. Larsen ◽  
Mandy Diskar ◽  
Paul H. Backe ◽  
Magnar Bjørås ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Protein Kinase A ◽  
Human Gene ◽  
Catalytic Subunit ◽  
Novel Mutations ◽  
Gene Encoding ◽  
Identification And Characterization ◽  
Kinase A

Chromosomal localization and preliminary characterization of the human gene encoding insulin-like growth factor II

1985 ◽  
Vol 69 (2) ◽  
pp. 170-173 ◽  
Author(s):  
P. de Pagter-Holthuizen ◽  
J. W. M. Höppener ◽  
M. Jansen ◽  
A. H. M. Geurts van Kessel ◽  
G. J. B. van Ommen ◽  
...  
Keyword(s):  
Growth Factor ◽  
Chromosomal Localization ◽  
Human Gene ◽  
Insulin Like Growth Factor ◽  
Gene Encoding ◽  
Preliminary Characterization ◽  
Factor Ii

Molecular characterization of the human gene encoding an abundant 61 kDa protein specific to the retinal pigment epithelium

1995 ◽  
Vol 4 (4) ◽  
pp. 641-649 ◽  
Author(s):  
Aileen Nicoletti ◽  
Deborah J. Wong ◽  
Kazuhide Kawase ◽  
Lisa H. Gibson ◽  
Teresa L. Yang-Feng ◽  
...  
Keyword(s):  
Retinal Pigment Epithelium ◽  
Molecular Characterization ◽  
Human Gene ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Gene Encoding

Structural and functional characterization of the upstream regulatory region of the human gene encoding prostate apoptosis response factor-4

Gene ◽  
2002 ◽  
Vol 295 (1) ◽  
pp. 109-116 ◽  
Author(s):  
Shu-Chi Hsu ◽  
Ford Kirschenbaum ◽  
Judy Miller ◽  
Barbara Cordell ◽  
Justin V. McCarthy
Keyword(s):  
Human Gene ◽  
Functional Characterization ◽  
Regulatory Region ◽  
Response Factor ◽  
Upstream Regulatory Region ◽  
Gene Encoding

scholarly journals Identification and Characterization of the Murine and Human Gene Encoding the Tuberoinfundibular Peptide of 39 Residues

Endocrinology ◽  
2002 ◽  
Vol 143 (3) ◽  
pp. 1047-1057 ◽  
Author(s):  
Markus R. John ◽  
Maya Arai ◽  
David A. Rubin ◽  
Kenneth B. Jonsson ◽  
Harald Jüppner
Keyword(s):  
Human Gene ◽  
Gene Encoding ◽  
Tuberoinfundibular Peptide ◽  
Identification And Characterization

scholarly journals Identification and characterization of a cDNA and the gene encoding the mouse ubiquitously expressed glucose-6-phosphatase catalytic subunit-related protein

2004 ◽  
Vol 32 (1) ◽  
pp. 33-53 ◽  
Author(s):  
JN Boustead ◽  
CC Martin ◽  
JK Oeser ◽  
CA Svitek ◽  
SI Hunter ◽  
...  
Keyword(s):  
Fusion Gene ◽  
Gene Promoter ◽  
Catalytic Subunit ◽  
Mouse Tissue ◽  
Related Protein ◽  
Subunit Gene ◽  
Chromosome 11 ◽  
Gene Encoding ◽  
Identification And Characterization

Glucose-6-phosphatase (G6Pase) catalyzes the final step in the gluconeogenic and glycogenolytic pathways, the hydrolysis of glucose-6-phosphate (G6P) to glucose and phosphate. This paper describes the identification and characterization of a cDNA and the gene encoding the mouse ubiquitously expressed G6Pase catalytic subunit-related protein (UGRP). The open reading frame of this UGRP cDNA encodes a protein (346 amino acids (aa); Mr 38,755) that shares 36% overall identity (56% similarity) with the mouse G6Pase catalytic subunit (357 aa; Mr 40,454). UGRP exhibits a similar predicted transmembrane topology and conservation of many of the catalytically important residues with the G6Pase catalytic subunit; however, unlike the G6Pase catalytic subunit, UGRP does not catalyze G6P hydrolysis and does not contain a carboxy-terminal di-lysine endoplasmic reticulum retention signal. UGRP mRNA was detected by RNA blot analysis in every mouse tissue examined with the highest expression in heart, brain, testis and kidney. Database analysis showed that the mouse UGRP gene is composed of six exons, spans approximately 4.2 kbp of genomic DNA and is located on chromosome 11 along with the G6Pase catalytic subunit gene. The UGRP gene transcription start sites were mapped by primer extension analysis, and the activity of the mouse UGRP gene promoter was analyzed using luciferase fusion gene constructs. In contrast to the G6Pase catalytic subunit gene promoter, the UGRP promoter was highly active in all cell lines examined.

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