Report of the First International Workshop on Human Chromosome 14 Mapping 1993

1994 ◽  
Vol 66 (1) ◽  
pp. 1-17 ◽  
Author(s):  
Diane Wilson Cox ◽  
Wesley McBride
Keyword(s):  
Human Chromosome ◽  
International Workshop ◽  
Chromosome 14

Report of the Second International Workshop on Human Chromosome 14 Mapping 1994

1995 ◽  
Vol 69 (3-4) ◽  
pp. 159-174 ◽  
Author(s):  
John H. Edwards ◽  
Diane W. Cox ◽  
Sally P. Craig
Keyword(s):  
Human Chromosome ◽  
International Workshop ◽  
Chromosome 14 ◽  
Second International

scholarly journals Mice Lacking Paternally Expressed Pref-1/Dlk1 Display Growth Retardation and Accelerated Adiposity

2002 ◽  
Vol 22 (15) ◽  
pp. 5585-5592 ◽  
Author(s):  
Yang Soo Moon ◽  
Cynthia M. Smas ◽  
Kichoon Lee ◽  
Josep A. Villena ◽  
Kee-Hong Kim ◽  
...  
Keyword(s):  
Human Chromosome ◽  
Growth Retardation ◽  
Uniparental Disomy ◽  
Chromosome 14 ◽  
Tissue Mass ◽  
Imprinted Gene ◽  
Maternal Uniparental Disomy ◽  
Skeletal Malformation

ABSTRACT Preadipocyte factor 1 (Pref-1/Dlk1) inhibits in vitro adipocyte differentiation and has been recently reported to be a paternally expressed imprinted gene at human chromosome 14q32. Studies on human chromosome 14 deletions and maternal uniparental disomy (mUPD) 14 suggest that misexpression of a yet-to-be-identified imprinted gene or genes present on chromosome 14 causes congenital disorders. We generated Pref-1 knockout mice to assess the role of Pref-1 in growth and in vivo adipogenesis and to determine the contribution of Pref-1 in mUPD. Pref-1-null mice display growth retardation, obesity, blepharophimosis, skeletal malformation, and increased serum lipid metabolites. Furthermore, the phenotypes observed in Pref-1-null mice are present in heterozygotes that harbor a paternally inherited, but not in those with a maternally inherited pref-1-null allele. Our results demonstrate that Pref-1 is indeed paternally expressed and is important for normal development and for homeostasis of adipose tissue mass. We also suggest that Pref-1 is responsible for most of the symptoms observed in mouse mUPD12 and human mUPD14. Pref-1-null mice may be a model for obesity and other pathologies of human mUPD14.

Molecular Cloning of an Inducible Cytotoxic T-Lymphocyte-Associated Gene (Hu-CTLA 1) and Gene Localization to Human Chromosome 14

1989 ◽  
pp. 574-577
Author(s):  
Patrick Haddad ◽  
Jean-Marc Zini ◽  
Marie-Veronique Clement ◽  
Jean-François Brunet ◽  
Marie-Genevieve Mattei ◽  
...  
Keyword(s):  
Human Chromosome ◽  
Molecular Cloning ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Gene Localization ◽  
Chromosome 14

Linkage between the variegate porphyria (VP) and the alpha-1-antitrypsin (PI) genes on human chromosome 14

1988 ◽  
Vol 79 (3) ◽  
pp. 289-290 ◽  
Author(s):  
S. Bissbort ◽  
H. W. Hitzeroth ◽  
D. P. du Wentzel ◽  
C. W. Van den Berg ◽  
H. Senff ◽  
...  
Keyword(s):  
Human Chromosome ◽  
Chromosome 14 ◽  
Variegate Porphyria ◽  
Alpha 1 Antitrypsin

Report of the Fourth International Workshop on Human Chromosome 18 Mapping 1996

1996 ◽  
Vol 75 (2-3) ◽  
pp. 111-131 ◽  
Author(s):  
Gary A. Silverman ◽  
Joan Overhauser ◽  
Steve Gerken ◽  
Ad Geurts van Kessel
Keyword(s):  
Human Chromosome ◽  
International Workshop ◽  
Chromosome 18
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