The gene for leukocyte antigen-related tyrosine phosphatase (LAR) is localized to human chromosome 1p32, a region frequently deleted in tumors of neuroectodermal origin

1992 ◽  
Vol 61 (4) ◽  
pp. 266-268 ◽  
Author(s):  
F.R. Jirik ◽  
K.W. Harder ◽  
I.G. Melhado ◽  
L.L. Anderson ◽  
A.M.V. Duncan
Keyword(s):  
Human Chromosome ◽  
Tyrosine Phosphatase ◽  
Leukocyte Antigen ◽  
Neuroectodermal Origin ◽  
Chromosome 1P32

The gene encoding CD23 leukocyte antigen (FCE2) is located on human chromosome 19

1990 ◽  
Vol 16 (3) ◽  
pp. 283-286 ◽  
Author(s):  
Vidar Wendel-Hansen ◽  
Mich�le Rivi�re ◽  
Masatsune Uno ◽  
Irma Jansson ◽  
Josiane Szpirer ◽  
...  
Keyword(s):  
Human Chromosome ◽  
Chromosome 19 ◽  
Gene Encoding ◽  
Leukocyte Antigen ◽  
Human Chromosome 19

scholarly journals Dendritic space-filling requires a neuronal type-specific extracellular permissive signal inDrosophila

2017 ◽  
Vol 114 (38) ◽  
pp. E8062-E8071 ◽  
Author(s):  
Amy R. Poe ◽  
Lingfeng Tang ◽  
Bei Wang ◽  
Yun Li ◽  
Maria L. Sapar ◽  
...  
Keyword(s):  
Dendritic Growth ◽  
Tyrosine Phosphatase ◽  
Receptive Fields ◽  
Time Lapse ◽  
Receptor Protein ◽  
Space Filling ◽  
Leukocyte Antigen ◽  
Somatosensory Neurons ◽  
Time Lapse Imaging

Neurons sometimes completely fill available space in their receptive fields with evenly spaced dendrites to uniformly sample sensory or synaptic information. The mechanisms that enable neurons to sense and innervate all space in their target tissues are poorly understood. UsingDrosophilasomatosensory neurons as a model, we show that heparan sulfate proteoglycans (HSPGs) Dally and Syndecan on the surface of epidermal cells act as local permissive signals for the dendritic growth and maintenance of space-filling nociceptive C4da neurons, allowing them to innervate the entire skin. Using long-term time-lapse imaging with intactDrosophilalarvae, we found that dendrites grow into HSPG-deficient areas but fail to stay there. HSPGs are necessary to stabilize microtubules in newly formed high-order dendrites. In contrast to C4da neurons, non–space-filling sensory neurons that develop in the same microenvironment do not rely on HSPGs for their dendritic growth. Furthermore, HSPGs do not act by transporting extracellular diffusible ligands or require leukocyte antigen-related (Lar), a receptor protein tyrosine phosphatase (RPTP) and the only knownDrosophilaHSPG receptor, for promoting dendritic growth of space-filling neurons. Interestingly, another RPTP, Ptp69D, promotes dendritic growth of C4da neurons in parallel to HSPGs. Together, our data reveal an HSPG-dependent pathway that specifically allows dendrites of space-filling neurons to innervate all target tissues inDrosophila.

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