Proceedings of the Second International Workshop on Human Chromosome 17 Mapping 1991

1991 ◽  
Vol 57 (2-3) ◽  
pp. 65-77 ◽  
Author(s):  
Pamela R. Fain ◽  
David H. Ledbetter ◽  
Ellen Solomon
Keyword(s):  
Human Chromosome ◽  
International Workshop ◽  
Chromosome 17 ◽  
Human Chromosome 17 ◽  
Second International

The Gene Encoding Protein Kinase SEK1 Maps to Mouse Chromosome 11 and Human Chromosome 17

Genomics ◽  
1996 ◽  
Vol 34 (3) ◽  
pp. 430-432 ◽  
Author(s):  
Robert A. White ◽  
Rowland T. Hughes ◽  
Linda R. Adkison ◽  
Gail Bruns ◽  
Leonard I. Zon
Keyword(s):  
Protein Kinase ◽  
Human Chromosome ◽  
Mouse Chromosome ◽  
Chromosome 17 ◽  
Chromosome 11 ◽  
Gene Encoding ◽  
Human Chromosome 17 ◽  
Mouse Chromosome 11 ◽  
Encoding Protein

Nucleotide sequence of the third cytokine LD78 gene and mapping of all three LD78 gene loci to human chromosome 17

DNA Sequence ◽  
1992 ◽  
Vol 3 (4) ◽  
pp. 203-212 ◽  
Author(s):  
M. Hirashima ◽  
T. Ono ◽  
M. Nakao ◽  
H. Nishi ◽  
A. Kimura ◽  
...  
Keyword(s):  
Nucleotide Sequence ◽  
Human Chromosome ◽  
Chromosome 17 ◽  
The Third ◽  
Human Chromosome 17

Report of the Second International Workshop on Human Chromosome 19 Mapping 1992

1992 ◽  
Vol 60 (2) ◽  
pp. 87-95 ◽  
Author(s):  
Hans Hilger Ropers ◽  
Margaret A. Pericak-Vance ◽  
Anthony V. Carrano
Keyword(s):  
Human Chromosome ◽  
International Workshop ◽  
Chromosome 19 ◽  
Human Chromosome 19 ◽  
Second International

Glial fibrillary acid protein, an astrocytic-specific marker, maps to human chromosome 17

Genomics ◽  
1991 ◽  
Vol 10 (4) ◽  
pp. 1087-1089 ◽  
Author(s):  
Elise Brownell ◽  
Alice S. Lee ◽  
Susan K. Pekar ◽  
Dimitrina Pravtcheva ◽  
Frank H. Ruddle ◽  
...  
Keyword(s):  
Human Chromosome ◽  
Chromosome 17 ◽  
Glial Fibrillary Acid Protein ◽  
Specific Marker ◽  
Acid Protein ◽  
Human Chromosome 17

scholarly journals Partial deletion of alpha satellite DNA associated with reduced amounts of the centromere protein CENP-B in a mitotically stable human chromosome rearrangement.

1990 ◽  
Vol 10 (12) ◽  
pp. 6374-6380 ◽  
Author(s):  
R Wevrick ◽  
W C Earnshaw ◽  
P N Howard-Peebles ◽  
H F Willard
Keyword(s):  
Human Chromosome ◽  
Satellite Dna ◽  
Centromeric Region ◽  
Chromosome Rearrangement ◽  
Specific Antigen ◽  
Chromosome 17 ◽  
Alpha Satellite ◽  
Protein Antigens ◽  
Alpha Satellite Dna ◽  
Human Chromosome 17

A familial, constitutionally rearranged human chromosome 17 is deleted for much of the DNA in its centromeric region but retains full mitotic centromere activity. Fluorescence in situ hybridization, pulsed-field gel electrophoresis, and Southern blot analysis of the residual centromeric region revealed a approximately 700-kb centromeric array of tandemly repeated alpha satellite DNA that was only approximately 20 to 30% as large as a normal array. This deletion was associated with a reduction in the amount of the centromere-specific antigen CENP-B detected by indirect immunofluorescence. The coincidence of the primary constriction, the small residual array of alpha satellite DNA, and the reduced amount of detectable CENP-B support the hypothesis that CENP-B is associated with alpha satellite DNA. Furthermore, the finding that both the deleted chromosome 17 and its derivative supernumerary fragment retained mitotic function and possess centromeric protein antigens suggests that human centromeres are structurally and functionally repetitive.

scholarly journals Amplification of the neu (c-erbB-2) oncogene in human mammmary tumors is relatively frequent and is often accompanied by amplification of the linked c-erbA oncogene.

1987 ◽  
Vol 7 (5) ◽  
pp. 2019-2023 ◽  
Author(s):  
M van de Vijver ◽  
R van de Bersselaar ◽  
P Devilee ◽  
C Cornelisse ◽  
J Peterse ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Chromosome ◽  
High Frequency ◽  
Human Breast Cancer ◽  
Functional Role ◽  
Chromosome 17 ◽  
Human Breast ◽  
Copy Numbers ◽  
Neu Oncogene ◽  
Human Chromosome 17

We investigated alterations in the structure and expression of oncogenes in mammary tumors and mammary tumor-derived cell lines. In 16 of 95 samples, we detected amplification of the human neu oncogene, also known as c-erB-2, accompanied by overexpression in the tumors from which intact RNA could be isolated. In 10 of these DNAs, the linked oncogene c-erbA was also amplified, whereas another gene on human chromosome 17, p53, was present in normal copy numbers. Overexpression of c-erbA could not be detected in the tumors analyzed. The relatively high frequency of neu amplification points to a functional role in human breast cancer. Coamplification of the c-erbA oncogene could contribute to this disease as well but is most likely fortuitous.

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