An extra segment in chromosome 1 of wild Mus musculus: a C-band positive homogeneously staining region

1984 ◽  
Vol 38 (4) ◽  
pp. 290-297 ◽  
Author(s):  
W. Traut ◽  
H. Winking ◽  
S. Adolph
Keyword(s):  
Mus Musculus ◽  
Chromosome 1 ◽  
Extra Segment

scholarly journals Effect of sperm genotype on chromatid segregation in female mice heterozygous for aberrant chromosome 1

1993 ◽  
Vol 61 (2) ◽  
pp. 97-100 ◽  
Author(s):  
Sergei I. Agulnik ◽  
Igor D. Sabantsev ◽  
Anatoly O. Ruvinsky
Keyword(s):  
Experimental Data ◽  
Mus Musculus ◽  
Meiotic Division ◽  
Chromosome 1 ◽  
Wild Populations ◽  
Aberrant Chromosome ◽  
Female Mice ◽  
Mus Musculus Musculus ◽  
Chromatid Segregation ◽  
Extra Segment

SummaryAn aberrant chromosome 1 with two large homogeneously staining insertions was isolated from wild populations of Mus musculus musculus. The specific features of the aberrant chromosome have been described elsewhere (Agulnik et al. 1990). These include its preferential entry into the oocyte of heterozygous females, increased mortality of homozygotes and decreased fertility of homozygous females. Here we present data indicating that chromatid segregation in heterozygous females depends upon which sperm enters the oocyte before the second meiotic division: meioticdrive is powerful when it is sperm bearing normal chromosome 1, and segregation normalizesduring Mil when it is sperm bearing chromosome 1 with the extra segment. Experimental data are adduced and explanations offered for the observed phenomenon.

scholarly journals Zoogeography of the Chromosome 1 HSR in Natural Populations of the House Mouse (Mus Musculus)

Hereditas ◽  
2004 ◽  
Vol 119 (1) ◽  
pp. 39-46 ◽  
Author(s):  
Sergel Agulnik ◽  
Sabine Adolph ◽  
Heinz Winking ◽  
Walther Traut
Keyword(s):  
House Mouse ◽  
Mus Musculus ◽  
Natural Populations ◽  
Chromosome 1

Polymorphic HSRs in chromosome 1 of the two semispecies Mus musculus musculus and M. m. domesticus have a common origin in an ancestral population

Chromosoma ◽  
1991 ◽  
Vol 100 (3) ◽  
pp. 147-151 ◽  
Author(s):  
H. Winking ◽  
A. Weith ◽  
B. Boldyreff ◽  
K. Moriwaki ◽  
K. Fredga ◽  
...  
Keyword(s):  
Mus Musculus ◽  
Common Origin ◽  
Chromosome 1 ◽  
Ancestral Population ◽  
Mus Musculus Musculus

A long-range repeat cluster in chromosome 1 of the house mouse, Mus musculus, and its relation to a germline homogeneously staining region

Genomics ◽  
1992 ◽  
Vol 12 (1) ◽  
pp. 80-88 ◽  
Author(s):  
L. Purmann ◽  
C. Plass ◽  
M. Grüneberg ◽  
H. Winking ◽  
W. Traut
Keyword(s):  
Long Range ◽  
House Mouse ◽  
Mus Musculus ◽  
Chromosome 1

Transcripts from amplified sequences of an inherited homogeneously staining region in chromosome 1 of the house mouse (Mus musculus)

1991 ◽  
Vol 11 (4) ◽  
pp. 2229-2235
Author(s):  
W A Eckert ◽  
C Plass ◽  
A Weith ◽  
W Traut ◽  
H Winking
Keyword(s):  
House Mouse ◽  
Dna Sequences ◽  
Mus Musculus ◽  
Genomic Sequence ◽  
Gene Families ◽  
Chromosome 1 ◽  
Homologous Sequence ◽  
Sequence Motifs ◽  
Reading Frame ◽  
Hybridization Data

Several populations of the house mouse, Mus musculus, are polymorphic for the presence or absence of an inherited homogeneously staining region (HSR) in chromosome 1. The HSR consists of highly amplified DNA sequences, present in low copy numbers in the HSR- genome. A cloned HSR-derived genomic sequence detected transcripts of about 1.3 and 4.5 kb on blots of poly(A)+ RNA from liver of HSR+ mice but not from that of HSR- mice. A cDNA library was established from RNA of HSR+ mice and screened with the HSR-derived genomic clone. Positive clones were isolated and shown to be complementary to the 1.3-kb RNA species and to amplified DNA sequences in the HSR+ genome. The combined sequence of four overlapping cloned cDNAs is 959 nucleotides long and includes an open reading frame encoding a putative protein of 208 amino acids. The pertinent gene is unidentified. No homologous sequence is stored in the EMBL data base. A stretch of 109 nucleotides at the 3' end of the 1.3-kb RNA homology region in the same genomic fragment, as indicated by hybridization data and sequence motifs resembling promoter elements. Thus, our data suggest that at least two genes or gene families are encoded in the HSR.

scholarly journals Transcripts from amplified sequences of an inherited homogeneously staining region in chromosome 1 of the house mouse (Mus musculus).

1991 ◽  
Vol 11 (4) ◽  
pp. 2229-2235 ◽  
Author(s):  
W A Eckert ◽  
C Plass ◽  
A Weith ◽  
W Traut ◽  
H Winking
Keyword(s):  
House Mouse ◽  
Dna Sequences ◽  
Mus Musculus ◽  
Genomic Sequence ◽  
Gene Families ◽  
Chromosome 1 ◽  
Homologous Sequence ◽  
Sequence Motifs ◽  
Reading Frame ◽  
Hybridization Data

Several populations of the house mouse, Mus musculus, are polymorphic for the presence or absence of an inherited homogeneously staining region (HSR) in chromosome 1. The HSR consists of highly amplified DNA sequences, present in low copy numbers in the HSR- genome. A cloned HSR-derived genomic sequence detected transcripts of about 1.3 and 4.5 kb on blots of poly(A)+ RNA from liver of HSR+ mice but not from that of HSR- mice. A cDNA library was established from RNA of HSR+ mice and screened with the HSR-derived genomic clone. Positive clones were isolated and shown to be complementary to the 1.3-kb RNA species and to amplified DNA sequences in the HSR+ genome. The combined sequence of four overlapping cloned cDNAs is 959 nucleotides long and includes an open reading frame encoding a putative protein of 208 amino acids. The pertinent gene is unidentified. No homologous sequence is stored in the EMBL data base. A stretch of 109 nucleotides at the 3' end of the 1.3-kb RNA homology region in the same genomic fragment, as indicated by hybridization data and sequence motifs resembling promoter elements. Thus, our data suggest that at least two genes or gene families are encoded in the HSR.

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