High frequency of X-Y chromosome dissociation in primary spermatocytes of F1hybrids between Japanese wild mice (Mus musculus molossinus) and inbred laboratory mice

1981 ◽  
Vol 29 (3) ◽  
pp. 166-175 ◽  
Author(s):  
H.T. Imai ◽  
Y. Matsuda ◽  
T. Shiroishi ◽  
K. Moriwaki
Keyword(s):  
Y Chromosome ◽  
Mus Musculus ◽  
High Frequency ◽  
Laboratory Mice ◽  
Wild Mice

X-Y chromosome dissociation in wild derived Mus musculus subspecies, laboratory mice, and their Fi hybrids

1982 ◽  
Vol 34 (3) ◽  
pp. 241-252 ◽  
Author(s):  
Y. Matsuda ◽  
H.T. Imai ◽  
K. Moriwaki ◽  
K. Kondo ◽  
F. Bonhomme
Keyword(s):  
Y Chromosome ◽  
Mus Musculus ◽  
Laboratory Mice

scholarly journals Y-chromosomal DNA polymorphism in mouse inbred strains

1987 ◽  
Vol 50 (1) ◽  
pp. 69-72 ◽  
Author(s):  
Yutaka Nishioka
Keyword(s):  
Y Chromosome ◽  
Mus Musculus ◽  
Dna Polymorphism ◽  
Inbred Strains ◽  
Laboratory Mice ◽  
Wild Populations ◽  
Chromosomal Dna ◽  
Mus Musculus Musculus

SummaryMice are the most widely used experimental mammals, and many inbred strains are available. However, except for the relatively recent strains derived from known wild populations, the relationships between wild and laboratory mice are not well understood. Based on the Y-chromosomal restriction fragmentlength polymorphism, seventeen inbred strains were classified into two groups: strains with the Mus musculus musculus type Y chromosome and those with the M. m. domesticus type Y chromosome. We extended the survey to an additional twenty-two inbred strains. The M. m. musculus type Y chromosome was found in AEJ/GnLe, AAU/SsJ, BDP/J, BXSB/MpJ, DA/HuSn, HTG/GoSfSn, I/LnJ, LP/J, NZW/LacJ, RIIIS/J, SB/Le, SEA/GnJ, SF/CamEi, SK/CamEi, SM/J, WB/ReJ, WC/ReJ and YBR/Ei, while the M. m. domesticus type Y chromosome was present in BUB/BnJ, MA/MyJ, PL/J and ST/bJ.

scholarly journals Evidences against a significant role of Mus musculus as natural host for Angiostrongylus costaricensis

1996 ◽  
Vol 38 (3) ◽  
pp. 171-175 ◽  
Author(s):  
Fernanda Teixeira dos Santos ◽  
Viviane M. Pinto ◽  
Carlos Graeff-Teixeira
Keyword(s):  
Significant Role ◽  
Mus Musculus ◽  
Natural Infection ◽  
Laboratory Mice ◽  
Wild Populations ◽  
Wild Rodents ◽  
Wild Mice ◽  
Swiss Mice ◽  
Natural Hosts

Wild rodents have been described as the most important hosts for Angiostrongylus costaricensis in Central America and southern Brazil. Sinantropic rodents apparently do not play a significant role as natural hosts. A search for natural infection failed to document worms in 14 mice captured in the house of a patient with diagnosis of abdominal angiostrongylosis and experimental infection of a "wild" Mus musculus strain and groups of albino Swiss mice were carried out. Mortality was not significantly different and varied from 42% to 80% for Swiss mice and from 26% to 80% for "wild" mice. The high mortality of a "wild" M. musculus infected with A. costaricensis was very similar to what is observed with most laboratory mice strains. These data may be taken as indications that M. musculus is not a well adapted host for A. costaricensis, although susceptibility was apparently higher with "wild" populations of M. musculus as compared to Swiss strain.

Homology of p53 intronic sequences between four laboratory mouse strains and Japanese wild mouse (Mus musculus molossinus Mishima)

Genome ◽  
1994 ◽  
Vol 37 (6) ◽  
pp. 1022-1026 ◽  
Author(s):  
Masayuki Tokumitsu ◽  
Katsuhiro Ogawa
Keyword(s):  
Loss Of Heterozygosity ◽  
Mus Musculus ◽  
Laboratory Mouse ◽  
Wild Mouse ◽  
P53 Gene ◽  
Inbred Strains ◽  
Mouse Strains ◽  
Restriction Enzyme Digestion ◽  
Laboratory Mice ◽  
Wild Mice

Strain variation in the mouse p53 gene sequences was investigated in various regions of the gene in 14 inbred strains of laboratory mice and one Japanese wild mouse strain (Mus musculus molossinus Mishima, M. MOL-MSM). Nucleotides within p53 introns 1 and 7, found to be identical in 10 of the laboratory strains (129/J, A/J, AKR/J, BALB/cJ, C3H/HeJ, C57BL/6J, CBA/J, CE/J, NZB, and SWR/J), were substituted for other nucleotide sequences in common with M. MOL-MSM and the four other strains (DBA/1J, DBA/2J, I/LnJ, and P/J). The latter were documented to have originated from a common ancestor. These observations thus suggested the possibility that the p53 gene may have become substituted by outcrossing of this ancestral strain with Asian mice; this is presumably related to the documentation that Japanese mice brought to western countries were used as laboratory mice early in this century. To establish p53 gene heterozygosity, female C3H/HeJ and male DBA/2J mice were mated to produce F1, hybrids (C3D2F1,). Electrophoresis of PCR fragments including polymorphic regions with or without restriction enzyme digestion, allowed clear distinction of paternal and maternal p53 alleles. These markers, therefore, should be useful for studying the loss of heterozygosity of the p53 gene during the carcinogenic process.Key words: p53 gene, polymorphism, Japanese wild mice, laboratory mice, loss of heterozygosity.

scholarly journals Sequence Diversity, Intersubgroup Relationships, and Origins of the Mouse Leukemia Gammaretroviruses of Laboratory and Wild Mice

2016 ◽  
Vol 90 (8) ◽  
pp. 4186-4198 ◽  
Author(s):  
Devinka Bamunusinghe ◽  
Zohreh Naghashfar ◽  
Alicia Buckler-White ◽  
Ronald Plishka ◽  
Surendranath Baliji ◽  
...  
Keyword(s):  
Host Range ◽  
Y Chromosome ◽  
House Mouse ◽  
Laboratory Mouse ◽  
Wild Mouse ◽  
Sequence Diversity ◽  
Laboratory Mice ◽  
Wild Mice ◽  
Mouse Leukemia ◽  
Leukemia Viruses

ABSTRACTMouse leukemia viruses (MLVs) are found in the common inbred strains of laboratory mice and in the house mouse subspecies ofMus musculus. Receptor usage and envelope (env) sequence variation define three MLV host range subgroups in laboratory mice: ecotropic, polytropic, and xenotropic MLVs (E-, P-, and X-MLVs, respectively). These exogenous MLVs derive from endogenous retroviruses (ERVs) that were acquired by the wild mouse progenitors of laboratory mice about 1 million years ago. We analyzed the genomes of seven MLVs isolated from Eurasian and American wild mice and three previously sequenced MLVs to describe their relationships and identify their possible ERV progenitors. The phylogenetic tree based on the receptor-determining regions ofenvproduced expected host range clusters, but these clusters are not maintained in trees generated from other virus regions. Colinear alignments of the viral genomes identified segmental homologies to ERVs of different host range subgroups. Six MLVs show close relationships to a small xenotropic ERV subgroup largely confined to the inbred mouse Y chromosome.envvariations define three E-MLV subtypes, one of which carries duplications of various sizes, sequences, and locations in the proline-rich region ofenv. Outside theenvregion, all E-MLVs are related to different nonecotropic MLVs. These results document the diversity in gammaretroviruses isolated from globally distributedMussubspecies, provide insight into their origins and relationships, and indicate that recombination has had an important role in the evolution of these mutagenic and pathogenic agents.IMPORTANCELaboratory mice carry mouse leukemia viruses (MLVs) of three host range groups which were acquired from their wild mouse progenitors. We sequenced the complete genomes of seven infectious MLVs isolated from geographically separated Eurasian and American wild mice and compared them with endogenous germ line retroviruses (ERVs) acquired early in house mouse evolution. We did this because the laboratory mouse viruses derive directly from specific ERVs or arise by recombination between different ERVs. The six distinctively different wild mouse viruses appear to be recombinants, often involving different host range subgroups, and most are related to a distinctive, largely Y-chromosome-linked MLV ERV subtype. MLVs with ecotropic host ranges show the greatest variability with extensive inter- and intrasubtype envelope differences and with homologies to other host range subgroups outside the envelope. The sequence diversity among these wild mouse isolates helps define their relationships and origins and emphasizes the importance of recombination in their evolution.

scholarly journals Insights into mammalian biology from the wild house mouse Mus musculus

eLife ◽  
2015 ◽  
Vol 4 ◽  
Author(s):  
Megan Phifer-Rixey ◽  
Michael W Nachman
Keyword(s):  
House Mouse ◽  
Mus Musculus ◽  
Genetic Model ◽  
Inbred Strains ◽  
Mendelian Inheritance ◽  
Model Organisms ◽  
House Mice ◽  
Small Subset ◽  
Wild Mice ◽  
Wide Range

The house mouse, Mus musculus, was established in the early 1900s as one of the first genetic model organisms owing to its short generation time, comparatively large litters, ease of husbandry, and visible phenotypic variants. For these reasons and because they are mammals, house mice are well suited to serve as models for human phenotypes and disease. House mice in the wild consist of at least three distinct subspecies and harbor extensive genetic and phenotypic variation both within and between these subspecies. Wild mice have been used to study a wide range of biological processes, including immunity, cancer, male sterility, adaptive evolution, and non-Mendelian inheritance. Despite the extensive variation that exists among wild mice, classical laboratory strains are derived from a limited set of founders and thus contain only a small subset of this variation. Continued efforts to study wild house mice and to create new inbred strains from wild populations have the potential to strengthen house mice as a model system.

THE EFFECT OF AGE ON TEMPERATURE SELECTION BY LABORATORY MICE (MUS MUSCULUS)

1966 ◽  
Vol 44 (4) ◽  
pp. 511-517 ◽  
Author(s):  
D. M. Ogilvie ◽  
R. H. Stinson
Keyword(s):  
Temperature Gradient ◽  
Mus Musculus ◽  
Selection Response ◽  
Laboratory Mice ◽  
Horizontal Temperature Gradient ◽  
Temperature Selection ◽  
Adult Level ◽  
Level Of Selection ◽  
High Level ◽  
Effect Of Age

Adult animals have been used for most of the previous mammalian temperature selection studies, and relatively few systematic observations have been made with young animals. In this investigation, laboratory mice (Mus musculus), ranging in age from 1 to 84 days, were studied in a horizontal temperature gradient established along a 5-ft copper bar. Despite poorly developed locomotion and cold immobilization, it was shown that the temperature selection response is present at birth. The initially high level of selection appeared to be maintained for about 2 weeks, after which it began to decrease, rapidly at first, and then more slowly until the adult level was reached.

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