Regional mapping of chromosome 15

1978 ◽  
Vol 22 (1-6) ◽  
pp. 511-512 ◽  
Author(s):  
L. Pajunen ◽  
E. Solomon ◽  
S. Burgess ◽  
M. Bobrow ◽  
S. Povey ◽  
...  
Keyword(s):  
Chromosome 15 ◽  
Regional Mapping

Syntenic assignment of CD3G to bovine chromosome 15

1999 ◽  
Vol 30 (1) ◽  
pp. 67-68
Author(s):  
M. R. V. Amarante ◽  
C. R. Lopes ◽  
J. E. Womack
Keyword(s):  
Bovine Chromosome ◽  
Chromosome 15

scholarly journals Mice with mutations in Trpm1, a gene in the locus of 15q13.3 microdeletion syndrome, display pronounced hyperactivity and decreased anxiety-like behavior

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Tesshu Hori ◽  
Shohei Ikuta ◽  
Satoko Hattori ◽  
Keizo Takao ◽  
Tsuyoshi Miyakawa ◽  
...  
Keyword(s):  
Visual Impairment ◽  
Wide Spectrum ◽  
Genetic Disorder ◽  
Mutant Mice ◽  
Chromosome 15 ◽  
Microdeletion Syndrome ◽  
Visual Transduction ◽  
The Central Nervous System ◽  
Null Mutant Mice

AbstractThe 15q13.3 microdeletion syndrome is a genetic disorder characterized by a wide spectrum of psychiatric disorders that is caused by the deletion of a region containing 7 genes on chromosome 15 (MTMR10, FAN1, TRPM1, MIR211, KLF13, OTUD7A, and CHRNA7). The contribution of each gene in this syndrome has been studied using mutant mouse models, but no single mouse model recapitulates the whole spectrum of human 15q13.3 microdeletion syndrome. The behavior of Trpm1−/− mice has not been investigated in relation to 15q13.3 microdeletion syndrome due to the visual impairment in these mice, which may confound the results of behavioral tests involving vision. We were able to perform a comprehensive behavioral test battery using Trpm1 null mutant mice to investigate the role of Trpm1, which is thought to be expressed solely in the retina, in the central nervous system and to examine the relationship between TRPM1 and 15q13.3 microdeletion syndrome. Our data demonstrate that Trpm1−/− mice exhibit abnormal behaviors that may explain some phenotypes of 15q13.3 microdeletion syndrome, including reduced anxiety-like behavior, abnormal social interaction, attenuated fear memory, and the most prominent phenotype of Trpm1 mutant mice, hyperactivity. While the ON visual transduction pathway is impaired in Trpm1−/− mice, we did not detect compensatory high sensitivities for other sensory modalities. The pathway for visual impairment is the same between Trpm1−/− mice and mGluR6−/− mice, but hyperlocomotor activity has not been reported in mGluR6−/− mice. These data suggest that the phenotype of Trpm1−/− mice extends beyond that expected from visual impairment alone. Here, we provide the first evidence associating TRPM1 with impairment of cognitive function similar to that observed in phenotypes of 15q13.3 microdeletion syndrome.

Further studies on chromosome 15 trisomy in murine T-cell lymphomas: Mapping of the relevant chromosome segment

1988 ◽  
Vol 41 (5) ◽  
pp. 738-743 ◽  
Author(s):  
Santiago Silva ◽  
Magda Babonits ◽  
Francis Wiener ◽  
George Klein
Keyword(s):  
T Cell ◽  
Chromosome Segment ◽  
Chromosome 15 ◽  
T Cell Lymphomas

A major locus (RN) affecting muscle glycogen content is located on pig Chromosome 15

1996 ◽  
Vol 7 (1) ◽  
pp. 52-54 ◽  
Author(s):  
P. Mariani ◽  
K. Lundström ◽  
U. Gustafsson ◽  
A. -C. Enfält ◽  
R. K. Juneja ◽  
...  
Keyword(s):  
Muscle Glycogen ◽  
Glycogen Content ◽  
Chromosome 15 ◽  
Major Locus ◽  
Muscle Glycogen Content
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