Further evidence for the assignment of the red cell acid phosphatase gene (ACP1) to the short arm of chromosome 2 from gene dosage effect

1976 ◽  
Vol 16 (1-5) ◽  
pp. 326-327
Author(s):  
R.E. Magenis ◽  
R.D. Koler ◽  
E. Lovrien ◽  
R.H. Bigley ◽  
M.C. DuVal ◽  
...  
Keyword(s):  
Acid Phosphatase ◽  
Gene Dosage ◽  
Dosage Effect ◽  
Red Cell ◽  
Chromosome 2 ◽  
Gene Dosage Effect ◽  
I Gene

Chemotherapy-induced myelosuppression in ovarian cancer patients with germline BRCA1/2 mutations: A case control study.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. 5571-5571
Author(s):  
Alan Christie ◽  
Amalina Che Bakri ◽  
Patricia Roxburgh ◽  
Muhammad Imtiaz Khan ◽  
Yousuf Iqbal ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Bone Marrow ◽  
Cancer Patients ◽  
Gene Dosage ◽  
Parp Inhibitor ◽  
Dosage Effect ◽  
Red Cell ◽  
Gene Dosage Effect ◽  
Cell Counts ◽  
Significant Difference

5571 Background: Ovarian cancer patients with germline BRCA1 or BRCA2 (gBRCA1/2) mutations frequently respond to multiple lines of chemotherapy. Having noticed significant myelosuppression during chemotherapy in gBRCA1/2 patients we wished to determine whether this was a chance finding or related to a heterozygous gene dosage effect in the bone marrow. Methods: gBRCA1/2 ovarian cancer patients from Edinburgh, Glasgow and Dundee were identified and matched for chemotherapy regimen, dose and age to controls from the Edinburgh Ovarian Cancer Database. Case notes and transfusion service records were analysed for chemotherapy details, haematology results, G-CSF use, red cell and platelet transfusions during first line chemotherapy. Results: Of 91 gBRCA1/2 patients, 35 patients were excluded who had previously received cytotoxic chemotherapy (mostly for breast cancer) or unusual chemotherapy regimens unable to be matched to controls. 56 were matched to controls. Baseline haematological indices were similar. There was a significant difference in the fall in haemoglobin levels from baseline to cycle 4 in gBRCA1/2 patients compared to controls (12.23% v 5.14%, p = 0.0005) and gBRCA1/2 patients had longer delays during their chemotherapy (mean 7.73 v 4.51 days, p = 0.0375) and more dose reductions for haemotoxicity (14 v 4 p = 0.0011). gBRCA1/2 were more likely to have a red cell transfusion (19 v 11, p = 0.099), and received more red cells (69 v 31 units, p = 0.0318). G-CSF was required in 3 BRCA patients versus 0 controls. Differences in platelet and white cell counts at cycle 4 were not significant. Conclusions: Patients with ovarian cancer and germline BRCA1/2 mutations were more likely to have significant falls in haemoglobin levels and require red cell transfusions and to experience delays during chemotherapy. This susceptibility to anaemia may be a hemizygous BRCA1/2 gene dosage effect manifest in the bone marrow and may have implications for the optimisation of cytotoxic and PARP inhibitor therapy in this patient group.

Evidence of a gene-dosage effect for the glucocorticoid receptor in trisomy 18 mice

1987 ◽  
Vol 116 (3_Suppl) ◽  
pp. S95-S96
Author(s):  
D. VOGLIOLO ◽  
H. WINKING ◽  
R. KNUPPEN
Keyword(s):  
Glucocorticoid Receptor ◽  
Gene Dosage ◽  
Dosage Effect ◽  
Trisomy 18 ◽  
Gene Dosage Effect

Apparent Lack of Gene Dosage Effect in the PLT Assay

1977 ◽  
Vol 6 (5) ◽  
pp. 529-532 ◽  
Author(s):  
S. JARAMILLO ◽  
G. ANHORN ◽  
F. SCHUNTER ◽  
P. WERNET
Keyword(s):  
Gene Dosage ◽  
Dosage Effect ◽  
Gene Dosage Effect ◽  
Apparent Lack

Gene dosage effect in expression of blood group antigens

1973 ◽  
Vol 83 (2) ◽  
pp. 167-172
Author(s):  
Li-Tsun Chen ◽  
Joseph A. Davidenas ◽  
Roal F. Ruth
Keyword(s):  
Blood Group ◽  
Gene Dosage ◽  
Dosage Effect ◽  
Blood Group Antigens ◽  
Gene Dosage Effect

scholarly journals THE GENETIC BASIS OF DOSAGE COMPENSATION OF ALCOHOL DEHYDROGENASE-1 IN MAIZE

Genetics ◽  
1981 ◽  
Vol 97 (3-4) ◽  
pp. 625-637 ◽  
Author(s):  
James A Birchler
Keyword(s):  
Alcohol Dehydrogenase ◽  
Structural Gene ◽  
Dosage Compensation ◽  
Genetic Basis ◽  
Gene Dosage ◽  
Dosage Effect ◽  
Gene Dosage Effect ◽  
Negative Effect ◽  
Higher Eukaryotes ◽  
Alcohol Dehydrogenase 1

ABSTRACT The levels of alcohol dehydrogenase (ADH) do not exhibit a structural gene-dosage effect in a one to four dosage series of the long arm of chromosome one (1L) (BIRCHLER19 79). This phenomenon, termed dosage compensation, has been studied in more detail. Experiments are described in which individuals aneuploid for shorter segments were examined for the level of ADH in order to characterize the genetic nature of the compensation. The relative ADH expression in segmental trisomics and tetrasomics of region IL 0.72–0.90, which includes the Adh locus, approaches the level expected from a strict gene dosage effect. Region IL 0.20–0.72 produces a negative effect upon ADH in a similar manner to that observed with other enzyme levels when IL as a whole is varied (BIRCHLEF1I9 79). These and other comparisons have led to the concept that the compensation of ADH results from the cancellation of the structural gene effect by the negative aneuploid effect. The example of ADH is discussed as a model for certain other cases of dosage compensation in higher eukaryotes.

D-Alanine-D-Alanine Ligase Gene (ddl) of Erwinia chrysanthemi Strain EC16 I. Isolation and Gene Dosage Effect on Pectate Lyase Synthesis

2002 ◽  
Vol 68 (4) ◽  
pp. 342-349
Author(s):  
Pongphen JITAREERAT ◽  
Hiroyuki MATSUMOTO ◽  
Masahiro UMEHARA ◽  
Shinji TSUYUMU
Keyword(s):  
Gene Dosage ◽  
Pectate Lyase ◽  
Dosage Effect ◽  
Erwinia Chrysanthemi ◽  
Gene Dosage Effect

Nosocomial superinfections due to linezolid-resistant Enterococcus faecalis: evidence for a gene dosage effect on linezolid MICs

2003 ◽  
Vol 47 (3) ◽  
pp. 511-513 ◽  
Author(s):  
Kathleen A. Ruggero ◽  
Laura K. Schroeder ◽  
Paul C. Schreckenberger ◽  
Alexander S. Mankin ◽  
John P. Quinn
Keyword(s):  
Enterococcus Faecalis ◽  
Gene Dosage ◽  
Dosage Effect ◽  
Gene Dosage Effect
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