Animal Models of Celiac Disease

2008 ◽  
pp. 210-216 ◽  
Author(s):  
Eric V. Marietta ◽  
Joseph A. Murray ◽  
Chella S. David
Keyword(s):  
Celiac Disease ◽  
Animal Models

scholarly journals Important Lessons Derived from Animal Models of Celiac Disease

2011 ◽  
Vol 30 (4) ◽  
pp. 197-206 ◽  
Author(s):  
E. V. Marietta ◽  
C. S. David ◽  
J. A. Murray
Keyword(s):  
Celiac Disease ◽  
Animal Models

scholarly journals Celiac disease: should we care about microbes?

2019 ◽  
Vol 317 (2) ◽  
pp. G161-G170 ◽  
Author(s):  
Alberto Caminero ◽  
Elena F. Verdu
Keyword(s):  
Celiac Disease ◽  
Animal Models ◽  
Environmental Factors ◽  
Cohort Studies ◽  
Immune Activation ◽  
Bacterial Infections ◽  
Opportunistic Pathogens ◽  
Gastrointestinal Infections

The prevalence of celiac disease (CeD) has increased in the last decades, suggesting a role for environmental factors in addition to gluten. Several cohort studies have shown that different gastrointestinal infections increase CeD risk. However, the mechanisms by which microbes participate in CeD have remained elusive. Recently, with the use of animal models, both viral and bacterial opportunistic pathogens were shown to induce immune activation relevant for CeD. The hypothesis that viral and/or bacterial infections can contribute to immune activation and breakdown of tolerance toward gluten in genetically susceptible individuals is therefore reinforced. Here, we discuss the evidence regarding the role of microbes in promoting CeD and the specific pathways triggered by microbes that could participate in CeD pathogenesis. Understanding these pathways will allow us to develop optimal microbiota-modulating strategies to help prevent CeD.

Using Animal Models of Celiac Disease to Understand the Role of MHC II

2013 ◽  
pp. 67-80
Author(s):  
Eric V. Marietta ◽  
Alberto Rubio-Tapia ◽  
Joseph A. Murray
Keyword(s):  
Celiac Disease ◽  
Animal Models ◽  
Mhc Ii

Autoimmune Reactions Induced by Gliadin Feeding in Germ-free AVN Rats and Athymic Nude Mice Animal Models for Celiac Disease

1997 ◽  
Vol 815 (1 B-Lymphocytes) ◽  
pp. 503-504 ◽  
Author(s):  
H. TLASKALOVÁ-HOGENOVÁ ◽  
R. ŠTĚPÁNKOVÁ ◽  
M. FARRÉ ◽  
D. P. FUNDA ◽  
Z. ŘEHÁKOVÁ ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Animal Models ◽  
Nude Mice ◽  
Athymic Nude Mice ◽  
Germ Free

Reductionist thinking and animal models in neuropsychiatric research

2019 ◽  
Vol 42 ◽  
Author(s):  
Nicole M. Baran
Keyword(s):  
Animal Models ◽  
Mental Disorders ◽  
Environmental Factors ◽  
Neuropsychiatric Disorders ◽  
Model Organisms ◽  
Developmental Genetic ◽  
Term Study ◽  
Genetic And Environmental Factors ◽  
Mechanisms Of Plasticity

AbstractReductionist thinking in neuroscience is manifest in the widespread use of animal models of neuropsychiatric disorders. Broader investigations of diverse behaviors in non-model organisms and longer-term study of the mechanisms of plasticity will yield fundamental insights into the neurobiological, developmental, genetic, and environmental factors contributing to the “massively multifactorial system networks” which go awry in mental disorders.

Tissue transglutaminase, the celiac disease autoantigen, preferentially generates antigenic neoepitopes in γ and γ but not in α gliadins

2001 ◽  
Vol 120 (5) ◽  
pp. A684-A684
Author(s):  
D TRAPP ◽  
W DIETERICH ◽  
H WIESER ◽  
M LEIDENBERGER ◽  
D SEILMEIER ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Tissue Transglutaminase

IgA-antitissue transglutaminase: Sensitivity and specificity for diagnosing Celiac Disease

2001 ◽  
Vol 120 (5) ◽  
pp. A395-A395
Author(s):  
J WEST ◽  
A LLOYD ◽  
P HILL ◽  
G HOLMES
Keyword(s):  
Celiac Disease ◽  
Sensitivity And Specificity

High prevalence of celiac disease in Migraine

2001 ◽  
Vol 120 (5) ◽  
pp. A393-A393
Author(s):  
M GABRIELLI ◽  
C PADALINO ◽  
E LEO ◽  
S DANESE ◽  
G FIORE ◽  
...  
Keyword(s):  
Celiac Disease ◽  
High Prevalence

Gender-related differences in pathogenesis and response to treatment of bone disorders of celiac disease (CD) patients

2001 ◽  
Vol 120 (5) ◽  
pp. A392-A392
Author(s):  
J FERRETI ◽  
R MAZURE ◽  
P TANOUE ◽  
A MARINO ◽  
G COINTRY ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Response To Treatment ◽  
Bone Disorders

Increased rectal permeability in celiac disease

2001 ◽  
Vol 120 (5) ◽  
pp. A131-A132
Author(s):  
E SMECUOL ◽  
E SUGAI ◽  
R DEZI ◽  
S NIVELONI ◽  
I DOLDAN ◽  
...  
Keyword(s):  
Celiac Disease
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