A Simplified Technique for Orthotopic Liver Transplantation in the Rat Using a Cuff Technique for Portal Vein and Infrahepatic Vena Cava Anastomoses

1981 ◽  
Vol 13 (3) ◽  
pp. 236-242 ◽  
Author(s):  
Joachim Limmer ◽  
Roy Y. Calne
2006 ◽  
Vol 12 (11) ◽  
pp. 1607-1614 ◽  
Author(s):  
Carlos Moreno ◽  
Antoni Sabaté ◽  
Joan Figueras ◽  
Imma Camprubí ◽  
Antonia Dalmau ◽  
...  

2019 ◽  
Vol 141 (5-6) ◽  
pp. 134-137

Abernethy malformation or congenital agenesis of the portal vein (CAPV) is a rare malformation of the abdominal splanchnic venous system. This malformation is commonly found in children and is often associated with other malformations such as congenital cardiac anomalies and skeletal system disorders, as well as liver tumors. There are two types of Abernethy malformation. In type I, portal blood bypasses the liver completely, with the superior mesenteric vein and the splenic vein draining into the inferior vena cava separately (type Ia), or together (type Ib). There are no intrahepatic portal vein branches in the liver. Type II is a partial portocaval shunt in which portal blood partially supplies the liver. There is no unified therapeutic approach for all patients with Abernethy malformation, however, liver transplantation is recommended in patients with liver disease (encephalopathy, poor liver function) and those with liver tumors. In this case report we present a case of Abernethy type Ib malformation in a 17-year-old patient with chronic malaise and uper abdominal pain. During diagnostic work-up, an unresectable liver tumor was found and the patient was successfully treated with orthotopic liver transplantation.


2019 ◽  
Vol 85 (1) ◽  
pp. 103-110 ◽  
Author(s):  
Robert M. Cannon ◽  
David N. Bolus ◽  
Jared A. White

Hepatocellular carcinoma (HCC) in proximity to major hepatic vasculature poses a risk for invasion, which would contraindicate liver transplantation, yet, is difficult to treat with thermal ablation. This study was undertaken to evaluate the feasibility of irreversible electroporation (IRE) as a bridge to transplantation for high-risk tumors. All patients with HCC in proximity to major hepatic vasculature treated with laparoscopic IRE as bridge to transplantation were studied. Patient and tumor characteristics, length of stay, and treatment-related complications were recorded. Tumor response was assessed with CT and explant pathology. Five patients with a median Model for End Stage Liver Disease (MELD) of 13 (7–21) underwent IRE. The median tumor size was 2.7 cm (1.5–3.7 cm). Adjacent structures included the right portal vein, hepatic veins/inferior vena cava (IVC) and left portal vein. Length of stay was one day for all patients. One patient suffered portal vein thrombosis. The transplant occurred at a median of 142 days (47–264) after IRE. Pathologic necrosis ranged from 30 to 100 per cent, without any vascular invasion. Four patients remain alive with no evidence of disease with median follow-up of 403 (227–623) days. The remaining patients died because of transplant-related complications onpost IRE day 297. IRE shows promise as a bridge to liver transplant for high risk HCC in a preliminary series, justifying further prospective evaluation.


2006 ◽  
Vol 47 (2) ◽  
pp. 130-134 ◽  
Author(s):  
A. Alfidja ◽  
A. Abergel ◽  
P. Chabrot ◽  
D. Pezet ◽  
C. Bony ◽  
...  

We report two cases of percutaneous transhepatic stenting of the portal vein to treat stenosis and occlusion disclosed 5 and 18 months, respectively, after orthotopic liver transplantation in two adult patients. If long-term patency is satisfactory, this technique should allow long-term management of portal vein stenosis and occlusion without the use of thrombolysis.


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