Effect of Low Molecular Dextran on Total Liver Blood Flow in Hemorrhagic Shock

1976 ◽  
Vol 8 (2) ◽  
pp. 132-139 ◽  
Author(s):  
Nils Darle ◽  
Robert C. Lim, jr.
Keyword(s):  
Blood Flow ◽  
Hemorrhagic Shock ◽  
Liver Blood Flow ◽  
Total Liver

scholarly journals A novel technique for the assessment of total liver blood flow in pregnancy: interrater and intrarater agreements

2017 ◽  
Vol 90 (1074) ◽  
pp. 20160805
Author(s):  
Eugenio P Q Aires ◽  
Mônica G Almeida ◽  
Vitor M Marques ◽  
Fernanda C da Silva ◽  
Renato A M de Sá ◽  
...  
Keyword(s):  
Blood Flow ◽  
Liver Blood Flow ◽  
Novel Technique ◽  
Total Liver ◽  
In Pregnancy

scholarly journals Preservation of hepatic blood flow by direct peritoneal resuscitation improves survival and prevents hepatic inflammation following hemorrhagic shock

2012 ◽  
Vol 303 (10) ◽  
pp. G1144-G1152 ◽  
Author(s):  
Ryan T. Hurt ◽  
Paul J. Matheson ◽  
Jason W. Smith ◽  
El Rasheid Zakaria ◽  
Saad P. Shaheen ◽  
...  
Keyword(s):  
Blood Flow ◽  
Liver Injury ◽  
Hemorrhagic Shock ◽  
Liver Perfusion ◽  
Liver Blood Flow ◽  
Dry Weight ◽  
Treated Group ◽  
Organ Injury ◽  
Edema Formation ◽  
Shed Blood

Conventional resuscitation (CR) from hemorrhagic shock (HS) results in gut and liver hypoperfusion, organ and cellular edema, and vital organ injury. Adjunct direct peritoneal resuscitation (DPR) with dialysate prevents gut vasoconstriction, hypoperfusion, and injury. We hypothesized that DPR might also improve hepatocellular edema, inflammation, and injury. Anesthetized male SD rats were assigned to groups ( n = 8/group): 1) sham (no HS); 2) HS (40% MAP/60 min) + intravenous fluid conventional resuscitation [CR; shed blood + 2 vol saline (SAL)/30 min]; 3) HS+CR+DPR (30 ml ip 2.5% glucose dialysate); or 4) HS+CR+SAL (30 ml ip saline). Histopathology showed lung and liver injury in HS+CR and HS+CR+SAL up to 24-h postresuscitation (post-RES) that was not in shams and which was prevented by adjunct DPR. Wet-to-dry weight ratios in HS+CR revealed organ edema formation that was prevented by adjunct DPR. HS+CR and HS+CR+SAL had 34% mortality by 24-h post-RES, which was absent with DPR (0%). Liver IFN-γ and IL-6 levels were elevated in CR compared with DPR or shams. TNF-α mRNA was upregulated in CR/sham and DPR/sham. IL-17 was downregulated in DPR/sham. CXCL10 mRNA was upregulated in CR/sham but downregulated in DPR/sham. Despite restored central hemodynamic performance after CR of HS, liver blood flow was compromised up to 24 h post-RES, and the addition of DPR restores and maintains liver perfusion at 24-h post-RES. DPR prevented liver injury, histological damage, and edema formation compared with CR alone. DPR provided a mitigating anti-inflammatory dampening of the systemic inflammatory response. In all, these effects likely account for improved survivorship in the DPR-treated group.

scholarly journals Experimental and Clinical Evaluation of Capsular and Parenchymal Total Liver Perfusion

HPB Surgery ◽  
1992 ◽  
Vol 6 (2) ◽  
pp. 99-104 ◽  
Author(s):  
Katerina Kotzampassi ◽  
Efthimios Eleftheriadis ◽  
Homeros Aletras
Keyword(s):  
Blood Flow ◽  
Laser Doppler Flowmetry ◽  
Liver Perfusion ◽  
Liver Blood Flow ◽  
Laser Doppler ◽  
Biliary Surgery ◽  
Flow Measurements ◽  
Doppler Flowmetry ◽  
Total Liver ◽  
Liver Surface

Liver blood flow measurements obtained from both the liver surface and deep within the parenchyma, were correlated in an effort to assess the usefulness of laser-Doppler flowmetry for non-invasive monitoring of total liver blood flow, the probe being positioned on either the surface or within the liver parenchyma.In 23 Wistar rats and 10 biliary surgery patients, anaesthetized prior to gallbladder removal, liver microcirculation was measured at 4 points on the capsular surface, and consequently at 4 points deep within the parenchyma, using probes connected to a laser-Doppler flowmeter. The findings revealed that laser-Doppler measurements on the liver surface and within the parenchyma were well correlated, as no statistically significant differences were found either in rats or humans. It is concluded that laser- Doppler flowmetry for monitoring of total liver perfusion can be applied either on the capsular surface or within the hepatic parenchyma.

119 Proposal of a new technique for evaluating the total liver blood flow volume during pregnancy by doppler sonography

2016 ◽  
Vol 6 (3) ◽  
pp. 237
Author(s):  
Eugênio Pacelli de Queiroz Ayres ◽  
Vitor Menezes Marques ◽  
Fernanda Campos da Silva ◽  
Monica Gomes de Almeida ◽  
Renato Augusto Moreira de sá ◽  
...  
Keyword(s):  
Blood Flow ◽  
Doppler Sonography ◽  
Liver Blood Flow ◽  
New Technique ◽  
Flow Volume ◽  
Blood Flow Volume ◽  
Total Liver ◽  
A New Technique

Destruction of Kupffer’s cells increases total liver blood flow and decreases ischemia reperfusion injury in pigs

1999 ◽  
Vol 31 (8) ◽  
pp. 3253-3254 ◽  
Author(s):  
M von Frankenberg ◽  
M Golling ◽  
A Mehrabi ◽  
H Nentwich ◽  
J Thies ◽  
...  
Keyword(s):  
Blood Flow ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Liver Blood Flow ◽  
Total Liver

scholarly journals Hemihepatectomy and Replacement of The Afferent Hepatic Blood Supply in The Dog

HPB Surgery ◽  
1989 ◽  
Vol 1 (2) ◽  
pp. 101-105 ◽  
Author(s):  
Egge J. Boerma ◽  
Herman H. M. de Boer ◽  
M. Niels van der Heyde ◽  
Urbain J. G. M. van Haelst
Keyword(s):  
Blood Flow ◽  
Portal Vein ◽  
Hepatic Artery ◽  
Blood Supply ◽  
Liver Blood Flow ◽  
Total Liver

Hemihepatectomy along with portal vein or hepatic artery replacement in dogs was well tolerated, but combined with replacement of both vessels it was lethal because of outflow block and shock. Total liver blood flow should be kept as high as possible during such procedures in man.

Liver Blood Flow as a Major Determinant of the Clearance of Recombinant Human Tissue-Type Plasminogen Activator

1992 ◽  
Vol 67 (01) ◽  
pp. 083-087 ◽  
Author(s):  
A de Boer ◽  
C Kluft ◽  
J M Kroon ◽  
F J Kasper ◽  
H C Schoemaker ◽  
...  
Keyword(s):  
Blood Flow ◽  
Rat Liver ◽  
Healthy Subjects ◽  
Liver Blood Flow ◽  
Major Determinant ◽  
Tissue Type ◽  
Perfused Rat Liver ◽  
Liver Model ◽  
Type Plasminogen Activator ◽  
Proportional Change

SummaryThe influence of changes in liver blood flow on the clearance of rt-PA was studied both in healthy subjects and in a perfused rat liver model. Liver blood flow in healthy subjects was documented indirectly by the clearance of indocyanine green (ICG). Exercise reduced liver blood flow on average by 57% with a 95% confidence interval (95% Cl) ranging from 51% to 62% (n = 5) and increased plasma levels of rt-PA activity (after an i. v. infusion of 18 mg of rt-PA over 120 min) by 119% (95% Cl, 58% - 203%) and rt-PA antigen by 91% (95% Cl, 30% - 140%). In the perfused rat liver model it was shown that halving or doubling of the physiological flow rate of a perfusate, containing rt-PA caused a proportional change in the clearance of rt-PA, while the extraction of rt-PA by the liver remained similar. In conclusion, liver blood flow is a major determinant of the clearance of rt-PA. This may have important implications for dosage of rt-PA in patients with myocardial infarction.

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