Chronic Administration of a New Potent Agonist of Growth Hormone-Releasing Hormone Induces Compensatory Linear Growth in Growth Hormone-Deficient Rats: Mechanism of Action

1996 ◽  
Vol 64 (3) ◽  
pp. 169-176 ◽  
Author(s):  
Magdolna Kovács ◽  
Gábor Halmos ◽  
Kate Groot ◽  
Jan Izdebski ◽  
Andrew V. Schally
Keyword(s):  
Growth Hormone ◽  
Mechanism Of Action ◽  
Linear Growth ◽  
Chronic Administration ◽  
Growth Hormone Releasing Hormone ◽  
Releasing Hormone ◽  
Potent Agonist

Growth hormone-releasing hormone in the diagnosis and treatment of growth hormone deficient children

1986 ◽  
Vol 113 (4_Suppl) ◽  
pp. S123-S129
Author(s):  
R.J.M. ROSS ◽  
A. GROSSMAN ◽  
G.M. BESSER ◽  
M.O. SAVAGE
Keyword(s):  
Growth Hormone ◽  
Linear Growth ◽  
Gh Deficiency ◽  
Venous Blood ◽  
Alternative Therapy ◽  
Normal Subjects ◽  
Growth Hormone Releasing Hormone ◽  
Releasing Hormone ◽  
Gh Secretion ◽  
Depot Preparations

ABSTRACT A growth hormone-releasing hormone (GHRH) has recently been extracted and synthesised, and appears to be identical to human hypothalamic GHRH. Immunoreactive GHRH is found in the venous blood of normal subjects and GH-deficient children, but is probably not hypothalamic in origin and therefore not important in GH regulation. GHRH is a potent specific stimulator of GH secretion in man, and provides a valuable diagnostic test in differentiating hypothalamic from pituitary causes of GH deficiency. Preliminary data suggests that GHRH may promote linear growth in some GH deficient children. GHRH may well prove an important alternative therapy for GH deficient children especially if depot preparations or intranasal administration prove effective.

Growth-hormone-releasing hormone

1990 ◽  
Vol 36 (3) ◽  
pp. 415-420 ◽  
Author(s):  
M L Vance
Keyword(s):  
Growth Hormone ◽  
Linear Growth ◽  
Clinical Medicine ◽  
Gh Deficiency ◽  
Peptide Hormone ◽  
Growth Hormone Releasing Hormone ◽  
Releasing Hormone ◽  
Gh Secretion ◽  
Gh Excess

Abstract Growth-hormone-releasing hormone (GHRH, somatoliberin) is the hypothalamic peptide hormone that specifically stimulates synthesis and release of growth hormone (GH, somatotropin) by somatotrope cells of the anterior pituitary gland. GHRH is the last of the classically postulated hypothalamic hormones to be characterized, synthesized, and used in clinical medicine. In this review of GHRH, I discuss the discovery and characterization of the peptide, its role in the regulation of GH secretion, and its clinical use in pathological states of GH excess and GH deficiency. The two most clinically useful aspects of GHRH are to establish the etiology of GH deficiency, most commonly the result of a hypothalamic GHRH deficiency, and to treat GH-deficient children. Use of GHRH as therapy for GH deficiency currently is experimental and, to date, results encourage the idea of a therapeutic role for this peptide in promoting endogenous GH secretion with resulting acceleration of linear growth.

Association of pituitary adenoma with neuronal christoma: A TEM study

1994 ◽  
Vol 52 ◽  
pp. 232-233
Author(s):  
Eva Horvath ◽  
Kalman Kovacs ◽  
B. W. Scheithauer ◽  
R. V. Lloyd ◽  
H. S. Smyth
Keyword(s):  
Growth Hormone ◽  
Pituitary Adenoma ◽  
Pituitary Tumor ◽  
Nervous Tissue ◽  
Alternative Explanation ◽  
Growth Hormone Releasing Hormone ◽  
Cell Hyperplasia ◽  
Releasing Hormone ◽  
Secretory Neurons

The association of a pituitary adenoma with nervous tissue consisting of neuron-like cells and neuropil is a rare abnormality. In the majority of cases, the pituitary tumor is a chromophobic adenoma, accompanied by acromegaly. Histology reveals widely variable proportions of endocrine and nervous tissue in alternating or intermingled patterns. The lesion is perceived as a composite one consisting of two histogenetically distinct parts. It has been suggested that the neuronal component, morphologically similar to secretory neurons of the hypothalamus, may initiate adenoma formation by releasing stimulatory substances. Immunoreactivity for growth hormone releasing hormone (GRH) in the neuronal component of some cases supported this view, whereas other findings such as consistent lack of growth hormone (GH) cell hyperplasia in the lesions called for alternative explanation.Fifteen tumors consisting of a pituitary adenoma and a neuronal component have been collected over a 20 yr. period. Acromegaly was present in 11 patients, was equivocal in one, and absent in 3.

Treatment with growth hormone-releasing hormone (GHRH) 1-44 stimulates growth velocity in growth hormone-deficient children

1989 ◽  
Vol 120 (3_Suppl) ◽  
pp. S85-S86
Author(s):  
Y.-F. SHI ◽  
X.-L. BAO ◽  
R. Liu ◽  
J.-Y. DENG ◽  
W. REINHARDT ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Velocity ◽  
Growth Hormone Releasing Hormone ◽  
Releasing Hormone
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