Stimulation of the Amygdala by Glutamate Facilitates Corticotropin-Releasing Factor Release from the Median Eminence and Activation of the Hypothalamic-Pituitary-Adrenal Axis in Stressed Rats

1995 ◽  
Vol 62 (4) ◽  
pp. 333-339 ◽  
Author(s):  
Rhonda W. Gabr ◽  
Dale L. Birkle ◽  
Albert J. Azzaro
Keyword(s):  
Median Eminence ◽  
Hypothalamic Pituitary Adrenal Axis ◽  
Corticotropin Releasing Factor ◽  
Hypothalamic Pituitary Adrenal ◽  
Adrenal Axis ◽  
Pituitary Adrenal Axis ◽  
Factor Release ◽  
Stimulation Of

Hypothalamic-pituitary-adrenal axis changes allow seasonal modulation of corticosterone in a bird

1998 ◽  
Vol 274 (5) ◽  
pp. R1338-R1344 ◽  
Author(s):  
L. Michael Romero ◽  
Kiran K. Soma ◽  
John C. Wingfield
Keyword(s):  
Hypothalamic Pituitary Adrenal Axis ◽  
Corticotropin Releasing Factor ◽  
Arginine Vasotocin ◽  
Free Living ◽  
Hypothalamic Pituitary Adrenal ◽  
Adrenal Axis ◽  
Maximal Output ◽  
Calcarius Lapponicus ◽  
Corticosterone Release ◽  
Pituitary Adrenal Axis

We examined possible mechanisms underlying seasonal stress modulation in Lapland longspurs ( Calcarius lapponicus), a species that breeds and molts (the energetically costly replacement of feathers) in the Alaskan Arctic. Free-living Lapland longspurs show dramatically reduced maximal corticosterone release during molt compared with the breeding season, an effect lost in captive birds. Neither changes in corticosterone binding proteins nor the overall condition of the bird (assessed by weight and fat storage) can explain different seasonal corticosterone responses. Adrenal insensitivity also does not fully explain reduced maximal output because exogenous ACTH enhanced corticosterone release during molt. Exogenous ACTH in molting birds, however, cannot stimulate corticosterone to stress-induced levels during breeding, implying reduced adrenal capacity. Lapland longspur pituitaries appeared to respond to exogenous corticotropin-releasing factor, arginine vasotocin, and mesotocin (the avian equivalents of arginine vasopressin and oxytocin) during molt, suggesting that a mechanism upstream of the pituitary blunts corticosterone release. Taken together, these results indicate that seasonal modulation of corticosterone release in this species is controlled at multiple sites in the hypothalamic-pituitary-adrenal axis.

Stimulation of the Hypothalamic-Pituitary-Adrenal Axis with the Opioid Antagonist Nalmefene

Pituitary ◽  
2005 ◽  
Vol 8 (2) ◽  
pp. 115-122 ◽  
Author(s):  
Eliza B Geer ◽  
Rita E Landman ◽  
Sharon L Wardlaw ◽  
Irene M Conwell ◽  
Pamela U. Freda
Keyword(s):  
Hypothalamic Pituitary Adrenal Axis ◽  
Opioid Antagonist ◽  
Hypothalamic Pituitary Adrenal ◽  
Adrenal Axis ◽  
Pituitary Adrenal Axis ◽  
Stimulation Of
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