Dexamethasone Decreases Somatostatin mRNA Levels in the Periventricular Nucleus of the Rat Hypothalamus

1993 ◽  
Vol 58 (3) ◽  
pp. 325-331 ◽  
Author(s):  
Karen S.L. Lam ◽  
Gopesh Srivastava ◽  
Sau-Ping Tam ◽  
Lap-Ping Chung ◽  
Sau-Fong Chan ◽  
...  
Keyword(s):  
Mrna Levels ◽  
Rat Hypothalamus ◽  
Periventricular Nucleus

Multihormonal Control of Pre-Pro-Somatostatin mRNA Levels in the Periventricular Nucleus of the Male and Female Rat Hypothalamus

1990 ◽  
Vol 52 (5) ◽  
pp. 527-536 ◽  
Author(s):  
Ricardo Zorrilla ◽  
Jacques Simard ◽  
Eric Rhéaume ◽  
Fernand Labrie ◽  
Georges Pelletier
Keyword(s):  
Mrna Levels ◽  
Female Rat ◽  
Male And Female ◽  
Rat Hypothalamus ◽  
Periventricular Nucleus

Influences of Hypothyroidism on TRH Concentrations and PreproTRH mRNA Levels in Rat Hypothalamus: A Simple and Reliable Method to Detect PreproTRH mRNA Level

1992 ◽  
Vol 55 (3) ◽  
pp. 317-320 ◽  
Author(s):  
Masanobu Yamada ◽  
Teturo Satoh ◽  
Tuyoshi Monden ◽  
Masami Murakami ◽  
Tokuji Iriuchijima ◽  
...  
Keyword(s):  
Reliable Method ◽  
Mrna Level ◽  
Mrna Levels ◽  
Rat Hypothalamus

Diurnal changes in actin mRNA levels and incorporation of35S-methionine into actin in the rat hypothalamus

1990 ◽  
Vol 10 (2) ◽  
pp. 207-216 ◽  
Author(s):  
Juan Iovanna ◽  
Nelson Dusetti ◽  
Ezequiel Calvo ◽  
Daniel P. Cardinali
Keyword(s):  
Diurnal Changes ◽  
Mrna Levels ◽  
Rat Hypothalamus ◽  
Actin Mrna

Eucommia Leaf Extract Induces BDNF Production in Rat Hypothalamus and Enhances Lipid Metabolism and Aerobic Glycolysis in Rat Liver

2020 ◽  
Vol 14 (2) ◽  
pp. 234-244
Author(s):  
Hirotaka Oikawa ◽  
Shouhei Miyazaki ◽  
Rina Kurata ◽  
Mutsumi Hattori ◽  
Noriko Hayashi ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Leaf Extract ◽  
Aerobic Glycolysis ◽  
Mrna Levels ◽  
Energy Regulation ◽  
Sprague Dawley ◽  
Creb Phosphorylation ◽  
Ras Protein ◽  
Rat Hypothalamus ◽  
Sprague Dawley Rats

Background: Mutations in the brain-derived neurotrophic factor (BDNF) gene and its receptor, tyrosine receptor kinase B (TrkB), have been reported to cause severe obesity in rodents. Our previous study demonstrated that the oral administration of 5% Eucommia leaf extract (ELE) or ELE aroma treatment (ELE aroma) produced anti-obesity effects. Objective: In this study, we investigated the effects of ELE on glycolysis and lipid metabolism in male Sprague–Dawley rats, as well as the effects of ELE on BDNF in rat hypothalamus. Methods and Results: A significant reduction and a reduction tendency in the respiratory quotient were observed in association with 5% ELE and ELE aroma treatment, respectively. Furthermore, RT-qPCR results showed significant increases in Cpt2, Acad, Complex II, and Complex V mRNA levels in the liver with both treatments. In addition, in rat hypothalamus, significant elevations in BDNF, Akt, PLCγ proteins and CREB phosphorylation were observed in the 5% ELE group and the ELE aroma group. Furthermore, Ras protein was significantly increased in the ELE aroma group. On the other hand, significant dephosphorylation of ERK1/2 was observed by the western blotting in the 5% ELE group and the ELE aroma group. Conclusion: These findings suggest that the ELE treatment enhances the lipid metabolism and increases the aerobic glycolytic pathway, while ELE-induced BDNF may affect such energy regulation. Therefore, ELE has the possibility to control metabolic syndrome.

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